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Did you mean Lysyl Hydroxylase?

GlossaryLysyl Hydroxylase

enzyme modifying lysine in collagen for tissue strength

Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

38 citations, June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

April 2012 in “KSBB Journal”

Minoxidil analogs can be improved for hair growth inhibition by modifying specific parts of their structure.

research Minoxidil Cannot Be Used To Target Lysyl Hydroxylases During Postnatal Mouse Lung Development: A Cautionary Note

2 citations, October 2020 in “Journal of Pharmacology and Experimental Therapeutics”

Minoxidil does not work to inhibit lysyl hydroxylases in newborn mouse lungs.

research Acne Scar Management: Minoxidil as a Promising Approach or a Mirage?

September 2023 in “International journal of biomedicine”

Minoxidil might help treat acne scars by reducing collagen buildup.

research Assessment of Hair and Cashmere Properties and Their Genetic Background of Several Goat Breeds in Southwest China

4 citations, July 2022 in “Scientific reports”

Crossbreeding improves goat fiber quality, and specific genes affect hair traits and color.

research Histological and Gene Expression Analysis of the Effects of Menopause Status and Hormone Therapy on the Vaginal Introitus and Labia Majora

7 citations, January 2019 in “Journal of clinical medicine research”

Menopause causes significant changes in the vaginal introitus, but less so in the labia majora, which may lead to symptoms of vaginal atrophy.

research Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil

63 citations, September 1987 in “Journal of Biological Chemistry”

Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.

Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

research Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

46 citations, December 1992 in “Journal of Investigative Dermatology”

Minoxidil decreases LH expression, while hydralazine has mixed effects on prolyl and lysyl hydroxylase activities.

research Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts

20 citations, January 1994 in “Archives of Biochemistry and Biophysics”

Minoxidil needs specific structure to block lysyl hydroxylase; exploring alternatives may keep benefits without this effect.

research Effects of Minoxidil on Cultured Human Skin Fibroblasts

19 citations, January 1987 in “Dermatology”

Minoxidil slows down skin cell growth and may help treat scars and skin conditions.

research Minoxidil and Male-Pattern Alopecia: A Potential Role for a Local Regulator of Sebum Secretion with Vasoconstrictive Effects?

5 citations, November 1999 in “Medical Hypotheses”

Minoxidil, a common hair loss treatment, might work by counteracting a hormone that reduces hair growth and promotes hair loss.

research Inflammatory Perifollicular Fibrosis And Alopecia

10 citations, June 1998 in “International Journal of Dermatology”

Inflammation around hair follicles leads to hair loss, and treatments should focus on reducing this inflammation and other factors for effectiveness.

Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

research Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

January 1989 in “Clinical and Experimental Dermatology”

The symposium concluded that hair growth involves complex processes, including the hair follicle life cycle, the role of the dermal papilla, hair strength, pigmentation, and the impact of diseases and treatments like minoxidil on hair and skin.

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

37 citations, January 1987 in “Dermatology”

Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.

research Androgenetic Alopecia, Trichotrophic Substances, and Histologic Studies of the Human Scalp

5 citations, October 1988 in “Clinics in Dermatology”

Minoxidil promotes hair growth but exact mechanism is unknown.

research Cardiac Outflow Tract Septation Defects in a DiGeorge Syndrome Model Respond to Minoxidil Treatment

March 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Minoxidil treatment improves heart defects in a DiGeorge syndrome model.

research Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from 278.15 to 333.15 K

24 citations, April 2011 in “Journal of Chemical & Engineering Data”

Minoxidil dissolves best in methanol and least in water.

research The Effect of Menopause on the Skin and Other Connective Tissues

44 citations, October 2011 in “Gynecological Endocrinology”

Menopause significantly reduces skin collagen, leading to thinner, less elastic skin, and hormone replacement may help but requires careful consideration.

research Effect of Minoxidil on Rabbit Lens Epithelial Cell Behavior In Vitro and In Situ

21 citations, September 2001 in “Graefes Archive for Clinical and Experimental Ophthalmology”

Minoxidil may help prevent capsular opacification after cataract surgery.

research Central Chorioretinopathy Associated with Topical Use of Minoxidil 2% for Treatment of Baldness

9 citations, September 2011 in “Cutaneous and Ocular Toxicology”

Using 2% minoxidil for baldness treatment might cause vision distortion due to fluid build-up under the retina.

research HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth

6 citations, January 2020 in “Skin Pharmacology and Physiology”

HIF-1α stimulators, like deferiprone, work as well as popular hair loss treatments, minoxidil and caffeine, in promoting hair growth.

research Estrogens and the Skin

137 citations, June 2005 in “Climacteric”

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

research Experimental and Thermodynamic Analyses of Supercritical CO2 Solubility of Minoxidil as an Antihypertensive Drug

28 citations, November 2020 in “Fluid Phase Equilibria”

Minoxidil dissolves better in propylene glycol + water than in supercritical CO2.

research Chapter 20: Pathogenesis and Treatment of Alopecias

8 citations, January 1989 in “Annual Reports in Medicinal Chemistry”

Hair loss from alopecia areata and androgenetic alopecia can be treated, but more effective and safer treatments are needed.

research Use of Topical Minoxidil, 17α-Estradiol, and Hydrocortisone Butyrate in Frontal Fibrosing Alopecia

1 citations, May 2014 in “European Journal of Inflammation”

A lotion with minoxidil, hydrocortisone butyrate, and 17a-estradiol can improve or stabilize Frontal Fibrosing Alopecia in some cases, but there's no universally-accepted treatment yet.

research The Induction by Topical Minoxidil of Increased Fenestration in the Perifollicular Capillary Wall

12 citations, February 1999 in “British Journal of Dermatology”

Minoxidil increased small openings in blood vessel walls near growing hair in rats.

research An Anti-Hair Loss Treatment in the Management of Mild Androgenetic Alopecia: Results from a Large, International Observational Study

1 citations, September 2021 in “Dermatologic Therapy”

AC5 improves hair loss and hair quality with high satisfaction rates.

research Drugs Affecting Hair Growth

January 1990

Different hair growth phases affect how follicles respond to X-rays, and hormones like testosterone and dihydrotestosterone play a key role in baldness; transplanted hair can grow on bald scalp areas.

research Minoxidil Stimulates Elastin Expression in Aortic Smooth Muscle Cells

33 citations, November 1994 in “Archives of Biochemistry and Biophysics”

ADM Scaffolds Generate a Pro-Regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

research ADM Scaffolds Generate a Pro-Regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

17 citations, June 2018 in “Frontiers in Physiology”

ADM scaffolds help skin heal by promoting a healing-type immune response.