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    Did you mean Lysyl Hydroxylase?
    Glossary Lysyl Hydroxylase

    enzyme modifying lysine in collagen for tissue strength

    Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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    Research 30 of 186

    1. Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis Matrix Biology · 2005 · 38 citations
    2. Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil. Journal of Biological Chemistry · 1987 · 63 citations
    3. Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note Journal of Pharmacology and Experimental Therapeutics · 2020 · 2 citations
    4. Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity KSBB Journal · 2012
    5. Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action Dermatology · 2009 · 37 citations
    6. Effects of Minoxidil on Cultured Human Skin Fibroblasts Dermatology · 1987 · 19 citations
    7. Inflammatory perifollicular fibrosis and alopecia International Journal of Dermatology · 1998 · 10 citations
    8. Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis Biomacromolecules · 2024 · 6 citations
    9. Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp Clinics in Dermatology · 1988 · 5 citations
    10. The Effect of the Drug Minoxidil on Hair Growth 1988 · 3 citations
    11. Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment. bioRxiv (Cold Spring Harbor Laboratory) · 2024
    12. Acne Scar Management: Minoxidil as a Promising Approach or a Mirage? International journal of biomedicine · 2023
    13. Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987 Clinical and Experimental Dermatology · 1989
    14. Chelators Depigment and Inorease Elasticity of Mink Skin Acta Agriculturae Scandinavica · 1987 · 2 citations
    15. Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation Archives of Dermatological Research · 2017 · 25 citations
    16. HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth Skin Pharmacology and Physiology · 2020 · 6 citations
    17. Liposomal Helix aspersa Snail Mucus: A Biomacromolecular Platform for Attenuating Chronological Skin Aging Through Modulation of miR-34a-Associated Senescence and Extracellular Matrix Remodeling International Journal of Molecular Sciences · 2026
    18. Matrisomal components involved in regenerative wound healing in axolotl and <i>Acomys</i>: implications for biomaterial development Biomaterials Science · 2023
    19. Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation Antibiotics · 2024 · 7 citations
    20. Minoxidil versus Nitroglycerin: A Prospective Double-Blind Controlled Trial in Transcutaneous Erection Facilitation for Organic Impotence The Journal of Urology · 1991 · 74 citations
    21. The effect of menopause on the skin and other connective tissues Gynecological Endocrinology · 2011 · 44 citations
    22. Identification of differentially expressed genes in actinic keratosis samples treated with ingenol mebutate gel PLOS ONE · 2020 · 4 citations
    23. Estrogens and the skin Climacteric · 2005 · 137 citations
    24. Chapter 20. Pathogenesis and Treatment of Alopecias Annual Reports in Medicinal Chemistry · 1989 · 8 citations
    25. Thrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with polycystic ovary syndrome Gynecological Endocrinology · 2009 · 29 citations
    26. Minoxidil Stimulates Elastin Expression in Aortic Smooth Muscle Cells Archives of Biochemistry and Biophysics · 1994 · 33 citations
    27. ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1 Frontiers in Physiology · 2018 · 17 citations
    28. A Novel Hair Restoration Technology Counteracts Androgenic Hair Loss and Promotes Hair Growth in A Blinded Clinical Trial Journal of Clinical Medicine · 2023 · 1 citations
    29. Expanding the therapeutic landscape of minoxidil for androgenetic alopecia: topical, oral and sublingual formulations Frontiers in Pharmacology · 2026
    30. Epithelial–mesenchymal transition in cutaneous fibrosis disease: from mechanisms to therapy Frontiers in Immunology · 2026