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Did you mean Lysyl Hydroxylase?

GlossaryLysyl Hydroxylase

enzyme modifying lysine in collagen for tissue strength

Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

38 citations, June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

April 2012 in “KSBB Journal”

Minoxidil analogs can be improved for hair growth inhibition by modifying specific parts of their structure.

research Acne Scar Management: Minoxidil as a Promising Approach or a Mirage?

September 2023 in “International journal of biomedicine”

Minoxidil might help treat acne scars by reducing collagen buildup.

research Skin Connective Tissue and Aging

77 citations, July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

research The Effect of Menopause on the Skin and Other Connective Tissues

44 citations, October 2011 in “Gynecological Endocrinology”

Menopause significantly reduces skin collagen, leading to thinner, less elastic skin, and hormone replacement may help but requires careful consideration.

research The Induction by Topical Minoxidil of Increased Fenestration in the Perifollicular Capillary Wall

12 citations, February 1999 in “British Journal of Dermatology”

Minoxidil increased small openings in blood vessel walls near growing hair in rats.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations, February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

research Clinical Role of Oral Vitamin C and E Therapy in Skin and Hair Disorders

June 2021 in “International journal of cosmetics and dermatology”

Vitamin C and E may help with certain skin and hair conditions, but more research is needed to confirm their effectiveness.

research Applications and Efficacy of Minoxidil in Dermatology

November 2024 in “Skin Health and Disease”

Minoxidil is effective for promoting hair growth and has various dermatological uses.

research A Novel Hair Restoration Technology Counteracts Androgenic Hair Loss and Promotes Hair Growth in a Blinded Clinical Trial

1 citations, January 2023 in “Journal of Clinical Medicine”

A new hair restoration technology was found to effectively increase hair thickness, density, and growth, while reducing hair loss and improving scalp health, with no side effects.

research Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from 278.15 to 333.15 K

24 citations, April 2011 in “Journal of Chemical & Engineering Data”

Minoxidil dissolves best in methanol and least in water.

research Estrogens and the Skin

137 citations, June 2005 in “Climacteric”

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

research Hormone Replacement Therapy and the Skin

138 citations, May 2000 in “Maturitas”

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Comparative Study Evaluating the Effectiveness of Intradermotherapy with 0.5% Minoxidil Versus Topical Application of 5% Minoxidil Solution in the Treatment of Androgenetic Alopecia

research Comparative Study Evaluating the Effectiveness of Intradermotherapy with 0.5% Minoxidil Versus Topical Application of 5% Minoxidil Solution in the Treatment of Androgenetic Alopecia

January 2025

Intradermotherapy with minoxidil is as effective as topical application for treating hair loss.

research Structure and Development of the Skin and Cutaneous Appendages

1 citations, July 2016 in “Elsevier eBooks”

Understanding skin structure and development helps diagnose and treat skin disorders.

research Thrombin Activatable Fibrinolysis Inhibitor and Other Hemostatic Parameters in Patients with Polycystic Ovary Syndrome

29 citations, January 2009 in “Gynecological Endocrinology”

Women with PCOS have higher levels of certain blood clotting factors, suggesting a greater risk of cardiovascular issues.

research Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture

23 citations, March 1988 in “Biochemical Pharmacology”

Minoxidil stops cells from making prostacyclin, which may help with hair growth. More research is needed.

research Expansion of Bacterial Phosphatidylglycerol Reactive CD4+ T Cells in Atopic Dermatitis

April 2021 in “Journal of Investigative Dermatology”

People with atopic dermatitis have more CD4+ T cells that respond to a certain bacterial lipid, which may play a role in the skin condition's inflammation.

research Expression of an Olfactomedin-Related Gene in Rat Hair Follicular Papilla Cells

10 citations, June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

FP-1 is a key protein in rat hair growth, active only during the growth phase.

research Fibroblasts: Origins, Definitions, and Functions in Health and Disease

488 citations, July 2021 in “Cell”

Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.

research Targeting Integrin Pathways: Mechanisms and Advances in Therapy

54 citations, January 2023 in “Signal Transduction and Targeted Therapy”

New therapies are being developed that target integrin pathways to treat various diseases.

Genetic Ablation of Myelin Protein Zero-Like 3 in Mice Increases Energy Expenditure, Improves Glycemic Control, and Reduces Hepatic Lipid Synthesis

research Genetic Ablation of Myelin Protein Zero-Like 3 in Mice Increases Energy Expenditure, Improves Glycemic Control, and Reduces Hepatic Lipid Synthesis

14 citations, May 2013 in “American Journal of Physiology-endocrinology and Metabolism”

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

research A Scoping Review of Pharmacotherapy, Complementary, and Alternative Medicine, and Surgical Therapies for Androgenic Alopecia

1 citations, March 2021 in “Current Dermatology Reports”

Various treatments help hair growth, but more research needed for safety and effectiveness.

research Cosmeceuticals: Peptides, Proteins, And Growth Factors

67 citations, May 2016 in “Journal of Cosmetic Dermatology”

Peptides, proteins, and growth factors in skincare show promise for improving skin health.

research Thyroid Hormone Action in Epidermal Development and Homeostasis and Its Implications in the Pathophysiology of the Skin

32 citations, March 2021 in “Journal of endocrinological investigation”

Thyroid hormones are important for skin health and changes in them can affect conditions like hair loss and eczema.

Col4a2-eGFP Mouse Model Reveals the Molecular and Functional Dynamics of Basement Membrane Remodelling in Hair Follicle Morphogenesis

research Col4a2-eGFP Mouse Model Reveals the Molecular and Functional Dynamics of Basement Membrane Remodelling in Hair Follicle Morphogenesis

November 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Scientists made a mouse that shows how a specific protein in the skin changes and affects hair growth and shape.

research Zinc Therapy in Dermatology: A Review

165 citations, January 2014 in “Dermatology Research and Practice”

Zinc is effective for treating various skin conditions, including warts and acne.

research Nutraceuticals: A Review

95 citations, February 2018 in “Dermatology and Therapy”

Nutraceuticals may improve skin health and protect against aging, but more research is needed on their optimal use and possible health risks.

research Advanced Polymer Hydrogels That Promote Diabetic Ulcer Healing: Mechanisms, Classifications, and Medical Applications

6 citations, February 2023 in “Biomaterials Research”

Special gels help heal diabetic foot sores and reduce the risk of amputation or death.

research Recent Progress in the Effect of Ferroptosis of Hepatic Stellate Cells on the Development of Liver Fibrosis

2 citations, September 2023 in “Frontiers in molecular biosciences”

Inducing ferroptosis in hepatic stellate cells is crucial for treating liver fibrosis.