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    Did you mean Lymphoid Enhancer-Binding Factor 1?
    Glossary Lymphoid Enhancer-Binding Factor 1

    protein regulating gene expression in immune cells and hair follicles

    Lymphoid Enhancer-Binding Factor 1 (LEF1) is a protein that plays a crucial role in the regulation of gene expression, particularly in the development and function of immune cells and hair follicles. It is part of the Wnt signaling pathway, which is important for cell growth, differentiation, and tissue regeneration. In the context of hair biology, LEF1 is involved in the formation and cycling of hair follicles, and its dysregulation can contribute to conditions like alopecia.

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    1. Lymphoid Enhancer-binding Factor-1 (LEF1) Interacts with the DNA-binding Domain of the Vitamin D Receptor Journal of Biological Chemistry · 2011 · 37 citations
    2. LncRNA-599547 contributes the inductive property of dermal papilla cells in cashmere goat through miR-15b-5p/Wnt10b axis Animal biotechnology · 2020 · 7 citations
    3. TERT/BMI1-transgenic human dermal papilla cells enhance murine hair follicle formation in vivo Journal of Dermatological Science · 2022 · 1 citations
    4. Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells Current Issues in Molecular Biology · 2023
    5. Hair Growth-Promoting Activity of Citron Seed Oil: Induction of Premature Telogen-To-Anagen Transition of Hair Follicle in C57BL/6 Mouse Models Current Topics in Nutraceutical Research · 2021
    6. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development The Journal of Cell Biology · 1998 · 318 citations
    7. Hair growth-promoting effects of Sargassum glaucescens oligosaccharides extracts Journal of The Taiwan Institute of Chemical Engineers · 2022 · 8 citations
    8. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    9. Tregs: Where We Are and What Comes Next? Frontiers in Immunology · 2017 · 130 citations
    10. Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis Clinical Cosmetic and Investigational Dermatology · 2025
    11. ILC3s as central regulators of mucosal homeostasis and disease pathogenesis (Review) International Journal of Molecular Medicine · 2026
    12. 328 The transcription factor CEBPB is a novel hub gene and multi-functional disease driver in Psoriatic skin inflammation Journal of Investigative Dermatology · 2022
    13. Systemic humoral activation facilitates tissue regeneration by D-chiral biomaterial scaffolds Cell Biomaterials · 2026
    14. Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/ ¥-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2019 · 37 citations
    15. Effect of Scenedesmus deserticola JD052 Extracts on Hair Inductivity by Regulating the AKT and GSK3β/β-Catenin Signaling Pathways in Human Dermal Papilla Cells Applied Sciences · 2025
    16. Gpr54 deletion accelerates hair cycle and hair regeneration EMBO Reports · 2024 · 1 citations
    17. Poly-D,L-Lactic Acid Filler Increases Hair Growth by Modulating Hair Follicular Stem Cells in Aged Skin Cells · 2025
    18. CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17 The Journal of Experimental Medicine · 2024 · 32 citations
    19. Camellia nitidissima Flower Extract Alleviates Dermal Papilla Cell Dysfunction by Regulating 11β-HSD1 and the TGF-β2/Smad and Wnt/β-Catenin Pathways Current Issues in Molecular Biology · 2026
    20. miR‐218‐5p regulates skin and hair follicle development through Wnt/β‐catenin signaling pathway by targeting SFRP2 Journal of cellular physiology · 2019 · 54 citations
    21. Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair Advances in Wound Care · 2019 · 10 citations
    22. A Treatment Combination of IGF and EGF Promotes Hair Growth in the Angora Rabbit Genes · 2020 · 26 citations
    23. Evaluation of the Effect of Plant Mixture Ethanol Extracts Containing Biota orientalis L. Extract on Suppression of Sebum in Cultured Sebocytes and on Stimulation of Growth of Keratinocytes Co-cultured with Hair Papilla Cells Cosmetics · 2017 · 4 citations
    24. Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Journal of the American Academy of Dermatology · 2011 · 232 citations
    25. Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth 2019 · 7 citations
    26. Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review) Molecular Medicine Reports · 2021 · 18 citations
    27. Gender Differences in Response to COVID-19 Infection and Vaccination Biomedicines · 2023 · 25 citations
    28. Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway Frontiers in Cell and Developmental Biology · 2021 · 11 citations
    29. Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity Immunological Reviews · 2025
    30. LHX2: a transcription factor in development, homeostasis, repair, and disease Frontiers in Cell and Developmental Biology · 2026