September 2022 in “The American Journal of Dermatopathology” This study found that IL-17 expression was significantly higher in perifollicular fibrosis of active Lichen planopilaris lesions, suggesting that targeting IL-17 could impact the disease's progression.
September 2022 in “Journal of the American Academy of Dermatology” This study compares the prevalence of vitamin D deficiency in patients with lichen planopilaris/frontal fibrosing alopecia to the general US population, highlighting an area not well-explored in existing research.
August 2022 in “IntechOpen eBooks” This review discusses treatments for frontal fibrosing alopecia and lichen planopilaris, noting that systemic 5-alpha reductase inhibitors are most effective for stabilization and potential hair regrowth, but reports no new clinical results.
This study identified discoid lupus erythematosus and pseudopelade of Brocq as the leading causes of scarring alopecia, highlighting the importance of skin punch biopsy for accurate diagnosis.
July 2022 in “JEADV Clinical Practice” This review discusses the classification of lichen planopilaris and its subtypes under the proposed term "lichenoid alopecias," suggesting they exist along a clinical and histological spectrum.
May 2022 in “Journal of Cosmetic Dermatology” This review discusses the characteristics and diagnostic challenges of fibrosing alopecia pattern distribution, proposing an algorithm for hair transplantation, but reports no new clinical results.
January 2022 in “Clinical Cases in Dermatology” This article discusses the causes and treatment options for lichen planopilaris, a scarring hair loss condition, but reports no new clinical findings.
November 2021 in “International Journal for Research in Applied Science and Engineering Technology” This review discusses the various applications of lyophilized platelet-rich plasma in treating different diseases and reports no new clinical results.
November 2021 in “CRC Press eBooks” This article reviews the characteristics and presentation of fibrosing alopecia in a pattern distribution, a form of scarring alopecia similar to androgenetic alopecia and lichen planopilaris, but provides no new clinical findings.
September 2021 in “Han'gug mi'saengmul saengmyeong gong haghoeji/Han-guk misaengmul saengmyeong gonghak hoeji” This study found that an ethanolic extract from the microalga Tetrathelmis tetrathele exhibited anti-inflammatory effects, promoted the proliferation of certain skin and hair cells, and inhibited 5α-reductase activity, suggesting its potential as a therapeutic agent for preventing alopecia and enhancing scalp health.
July 2021 in “Australasian Journal of Dermatology” This manuscript describes a proposed ‘trichoscopy-assisted hair pull test’ that enhances the diagnosis of hair loss conditions by allowing immediate examination of proximal hair shafts and roots in patients with a positive hair pull test.
July 2021 in “Authorea (Authorea)” This article discusses Graham-Little Piccardi Lassueur Syndrome, a rare variant of Lichen planopilaris, but reports no clinical findings or results.
April 2021 in “Journal of Investigative Dermatology” This study found that CD1a-restricted CD4+ T cells responsive to lysyl-phosphatidylglycerol were more frequent in the blood of atopic dermatitis patients, suggesting a potential role in the disease's Th2-mediated pathology.
April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study examined clinical characteristics of lichen planopilaris and frontal fibrosing alopecia in 24 men, revealing common scalp symptoms, frequent beard involvement, and limited association with thyroid disease.
March 2021 in “CRC Press eBooks” This article reviews the complexities and challenges in hair transplant procedures, emphasizing the role of micro-inflammation and the usefulness of trichoscopy for detecting complications, and reports no new clinical results.
March 2021 in “CRC Press eBooks” This chapter reviews trichoscopic features of primary cicatricial alopecias, particularly lichen planopilaris and frontal fibrosing alopecia, and reports no new results.
December 2020 in “Journal of Face Aesthetics” This study found that trichoscopy, a non-invasive diagnostic method, may effectively differentiate between types of focal alopecia in the parietal area in adult women, indicating specific trichoscopic features for conditions like alopecia areata, discoid lupus erythematosus, and lichen planopilaris.
December 2020 in “Skin appendage disorders” This discussion highlights the evolving clinical spectrum of lichen planopilaris, noting atypical features and presentations in younger males that suggest potential different pathomechanisms from previously recognized variants.
September 2020 in “Journal of Cutaneous Pathology” In this case study, a 69-year-old woman with pityriasis rubra pilaris developed a scarring alopecia with lichen-planopilaris-like features, which responded well to early treatment.
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that fibrosis-associated trochanters in central centrifugal cicatricial alopecia are enriched with hair follicle stem cells and may indicate a disrupted stem cell niche contributing to scarring.
April 2020 in “The FASEB Journal” This study found that disrupting testosterone biosynthesis in male rats mitigated cardiovascular and autonomic impairments caused by endotoxemia, indicating testosterone's significant role in these conditions.
January 2020 in “JAAD case reports” This article reviews current understanding of frontal fibrosing alopecia and lichen planopilaris, highlighting increasing incidence and unclear pathogenesis, and emphasizes the role of inflammatory destruction of hair follicular stem cells; it reports no new clinical findings.
September 2019 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” Isotretinoin at low doses effectively treats facial papules in frontal fibrosing alopecia.
April 2019 in “Journal of Investigative Dermatology” This study found that lichen planopilaris is associated with three core molecular pathways, which may inform new therapeutic strategies for scarring alopecia, including unique pathways like ABC transporters specific to LPP.
January 2019 in “The Egyptian Journal of Hospital Medicine” In this study, researchers evaluated trichoscopic features in 500 Egyptian patients with patchy hair loss and found specific patterns, such as perifollicular scale with 90% sensitivity and 99.5% specificity, which effectively aid in diagnosing primary cicatricial alopecias.
September 2018 in “Journal of Experimental & Biomedical Sciences” This study found that DK peptides demonstrated potent inhibition of 5α-reductase, suggesting they may be promising candidates for treating hair loss.
September 2018 in “Fertility and Sterility” This study observed that inflammatory stimuli significantly altered gene expression in rat theca-interstitial cells, affecting pathways related to growth and androgen production, which are central features of polycystic ovary syndrome.
July 2018 in “Elsevier eBooks” This study highlights lichen planopilaris as a form of scarring hair loss with symptoms like shedding and itching, and notes successful treatment options such as topical and oral antiinflammatory medications to preserve hair follicles by early intervention.
April 2018 in “Journal of Investigative Dermatology” This study found that the PPAR-γ modulator AGED can reverse epithelial-mesenchymal transition in hair follicles affected by lichen planopilaris ex vivo, suggesting potential for treating scarring alopecias.
April 2018 in “Journal of Investigative Dermatology” This study suggests that macrophages play a more substantial role in the pathogenesis of Lichen planopilaris compared to Frontal fibrosing alopecia, as indicated by increased CD68+ cells in Lichen planopilaris.