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Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

Melasma is a skin condition linked to female hormones, genetics, UV exposure, and certain medications, but not to pituitary, adrenal, or thyroid diseases.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.

Caesalpinia bonduc seed extracts may help treat enlarged prostate in rats.

Oestrogens are key for bone growth during puberty in both boys and girls.

Testosterone is important for men's sexual function, may help some women's sexual desire, while other hormones and neurotransmitters also play complex roles in sexual behavior.

Frontal fibrosing alopecia mainly affects postmenopausal women and may be linked to thyroid hormones.

Cirrhosis affects quality of life with various symptoms, requiring a holistic, multidisciplinary approach for management.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

Birth control pills can cause skin issues but may help with acne and hirsutism, and choosing the right type can minimize side effects.

Menopause can cause hair thinning and texture changes due to hormonal and metabolic shifts.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

5α-reductase inhibitors may worsen sexual drive and spontaneous erections but don't worsen existing erectile or ejaculatory problems.

Certain drugs, especially antiandrogens and spironolactone, significantly increase the risk of gynecomastia.

Most postmenopausal women experience significant skin changes and various skin conditions.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

A certain mutation in the fetal alpha 5-reductase gene is linked to a higher risk of late miscarriage.

Rare adrenal cancers that secrete androgens or estrogens have a poor prognosis and are treated primarily with surgery.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Some women with acne have higher levels of free testosterone, which might suggest using hormonal treatments for acne.

Women with PCOS have higher oxidative stress and hormone imbalances, suggesting managing oxidative stress could help.

Finasteride may cause breast enlargement, low testosterone a risk factor.

After menopause, women lose a lot of skin collagen, but estrogen replacement might improve skin health.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

Two women with very high androgen levels had only slight skin issues, one due to a non-classical adrenal disorder and the other due to an adrenal tumor.

Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.