March 2017 in “European Urology Supplements” This study found that variations in (CAG)n and (GGN)n polymorphisms in the androgen receptor gene appear to influence symptom severity in men with post-finasteride syndrome.
2 citations
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July 2007 in “Cancer biology & therapy” This study found that 86% of patients with follicular non-Hodgkin's lymphoma were alive and nearly two-thirds remained in complete remission eight years after initial treatment with the radioimmunotherapy drug Bexxar.
January 2026 in “Frontiers in Cellular Neuroscience” This study discusses the complex roles and effects of brain-synthesized sex neurosteroids, highlighting sex differences in their concentrations and their varied impacts on synaptic plasticity, cognitive behavior, and aging-related cognitive decline.
11 citations
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January 2020 in “Epidemiology and Psychiatric Sciences” Antidepressants can cause long-term side effects like severe withdrawal symptoms and sexual dysfunction, which can last for months or years after stopping the medication.
96 citations
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October 1987 in “The Journal of Clinical Endocrinology & Metabolism” This study found that long-term GnRH agonist administration in premenopausal women with polycystic ovarian disease resulted in persistent suppression of ovarian steroid secretion, while adrenal steroid levels remained unchanged.
42 citations
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April 2011 in “Annals of Pharmacotherapy” This study found that long-term flutamide treatment reduced hair loss in women with female pattern hair loss, but liver-related dropouts were minimized at a very low dose of 62.5 mg/day.
This study found flutamide to be an effective long-term treatment for female pattern hair loss with improved alopecia scores and high compliance when using very low doses, though some potential for hepatic disorders was observed initially.
109 citations
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July 1984 in “Circulation” This study found that long-term minoxidil treatment, despite improving hemodynamics and left ventricular function, was associated with more frequent clinical events and a poorer clinical course in patients with chronic left ventricular failure.
19 citations
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January 2011 in “Frontiers in Endocrinology” The study found that social isolation in mice increases the sensitivity of their hippocampal synapses to ethanol's inhibitory effects on long-term potentiation, an effect preventable by finasteride.
January 2005 in “Zhonghua xingwei yixue yu naokexue zazhi” This study found that long-term selenium and iodine deficiencies in rats led to growth delays and abnormal neural behavior by the fourth generation.
10 citations
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February 2017 in “European journal of neuroscience/EJN. European journal of neuroscience” This study found that local synthesis of 17β-estradiol and 5α-dihydrotestosterone, combined with specific stimulation patterns, is crucial in determining the direction and strength of long-term synaptic effects in the hippocampal CA1 region of male rat slices.
April 2021 in “IntechOpen eBooks” This article discusses the need to investigate long-term effects of androgen manipulations independently of current levels, referencing Post-finasteride Syndrome as a relevant clinical example, and reports no new results.
82 citations
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July 2011 in “Journal of Neuroscience” In this study, ethanol was found to enhance GABAergic neurosteroid production and inhibit long-term potentiation in rat hippocampal slices via unblocked NMDA receptor activation, effects reversible by specific inhibitors.
3 citations
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February 2023 in “Journal of Infection and Public Health” More symptoms during initial COVID infection increase the risk of long-term effects.
January 2017 in “Scripta Scientifica Vox Studentium” This review discusses the sexual side effects of long-term finasteride usage in men, noting varied reports of sexual dysfunction which typically improve over time; it presents no new experimental data.
23 citations
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July 2021 in “International Journal of Pharmaceutics” This study describes the development of microneedle array patches for finasteride that released the drug over 7 to 14 days in vitro, suggesting a potential alternative to oral treatments for long-term management of benign prostatic hyperplasia and androgenic alopecia.
March 2014 in “Human Physiology” This study found that prolonged administration of DHEA improved long-term memory and brain activity balance in old rhesus macaques, with effects like increased motor activity and restored hair lasting a year.
19 citations
,
January 2012 in “Frontiers in Neural Circuits” This study found that neurosteroids and benzodiazepines decrease network excitability in neuronal cultures, with specific long-term depressive effects on inhibitory neurons.
13 citations
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January 2016 in “Journal of Ophthalmology” This study found that using the novel eyelid shampoo ESL improved eyelid hygiene, reduced dry eye symptoms in meibomian gland dysfunction patients, and increased eyelash length over 8 weeks.
September 2024 in “African Journal of Biomedical Research” This review highlights the potential health risks associated with long-term use of cosmetics containing heavy metals, like cancer and neurological disorders, emphasizing the need for regular monitoring of these substances in cosmetic products.
9 citations
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May 2016 in “Veterinary dermatology” This case report describes how a long-term combination of oral fatty acids and topical therapy appeared beneficial for managing autosomal recessive congenital ichthyosis in a goldendoodle with a PNPLA1 mutation.
111 citations
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August 2015 in “Reviews in Endocrine and Metabolic Disorders” 5α-reductase inhibitors may cause persistent sexual dysfunction and depression, needing more research on long-term effects.
In this study, topical sildenafil citrate was found to improve hair regeneration in a rat model of androgenic alopecia, showing superior long-term effects compared to minoxidil, including increased hair follicle numbers and epidermal thickness.
31 citations
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November 2003 in “Journal of Occupational Health” This study found that the reproductive function of female hairdressers may be negatively affected by long-term exposure to permanent-waving solutions containing thioglycolic acid, raising concerns about its potential carcinogenic effects.
May 2025 in “Veterinary Medicine and Science” In this study, oral melatonin given to male Pomeranian dogs with Alopecia X improved semen quality and testicular blood flow in a dose-dependent manner, but altered hormonal balance, indicating complex effects that require further investigation for long-term implications.
7 citations
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May 2017 in “Research and Practice in Thrombosis and Haemostasis” This case report observed that a 20-year-old female with recurrent DVTs experienced reversible alopecia with various anticoagulants, except fondaparinux which allowed long-term treatment without this side effect.
January 2025 in “Digital Commons - Gardner-Webb University (Gardner–Webb University)” This review discusses the adverse effects and societal influence of anabolic-androgenic steroid abuse, emphasizing its severe long-term health risks and calling for increased awareness and regulation; it reports no new results.
May 2010 in “Deleted Journal” PCOS causes menstrual issues, infertility, and long-term health risks.
5 citations
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August 2024 in “Cureus” In this study, GLP-1 receptor agonists reduced BMI and improved metabolic and reproductive outcomes in women with PCOS, though the long-term effects remain unclear.
1 citations
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January 2024 in “Microorganisms” This study suggests that the synthetic peptide SPIKENET (SPK) may protect against long-term skin alterations in mice following coronavirus infection, offering potential therapeutic intervention for similar effects in humans post-COVID-19.