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Menopause causes significant changes in the vaginal introitus, but less so in the labia majora, which may lead to symptoms of vaginal atrophy.

Genetic mutations can affect female sexual development, requiring personalized medical care.

The document concludes that treating female hair loss should target reducing excess androgen and blocking its effects on hair follicles, with the best treatments being hormonal therapy, adrenal suppression, and topical minoxidil.

Androgens and estrogens are crucial for insulin secretion in males.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Estradiol-rich plasma can increase hair density faster and more effectively in male pattern baldness treatment than regular plasma.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.

Testosterone can build muscle and bone without enlarging the prostate when a specific enzyme is blocked.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

The document concludes that individualized treatment and lifestyle changes are important for managing menopause symptoms and health risks.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Primary care doctors should address female sexual dysfunctions to improve women's sexual health and life quality.

New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.

Oxidative stress is higher in women with PCOS, especially if they're obese, and it may increase their risk of heart disease.

Certain drugs can worsen hair loss in people prone to androgenetic alopecia.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

Estrogen is important for keeping adult mouse nipple skin healthy by controlling certain cell signals.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

Retinoic acid affects male and female muscle energy use and function differently.

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

Hormonal therapy is a good option for women with severe acne, especially when there's a chance of hormone imbalance.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

High testosterone increases heart disease risk in women with PCOS.