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This review discusses severe insulin resistance syndromes, highlighting their diagnostic challenges, potential novel therapies like leptin replacement, and suggests metformin and lifestyle changes in its absence; no new clinical results are reported.

This case report highlights a female patient with familial partial lipodystrophy who showed significant improvement in liver stiffness after starting leptin replacement therapy.

This study found that testosterone therapy improved physical performance and strength in older men with low testosterone over 36 months, whether administered alone or with finasteride.

This review discusses the role of androgens in women's sexual health and highlights the need for further research on androgen replacement therapy to optimize quality of life, but reports no new clinical results.

This review discusses the clinical implications of female androgen deficiency and evaluates treatment options, emphasizing the need for cautious use of replacement therapy in women with severe deficiency and matching symptoms.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

In this study, female patients undergoing hormone replacement therapy showed improvements in frontal hairline appearance and increased hair plucking strength, suggesting positive effects of estradiol on hair growth while excluding age-related factors.

New treatments for male hypogonadism are effective and should be personalized.

This article reviews the coordination of the hypothalamic-pituitary-gonadal axis, male fertility, and therapies for hypogonadism, but reports no new clinical findings.

This review examines intrinsic and extrinsic aging impacts and presents evidence-based lifestyle recommendations to complement cosmetic procedures for enhanced antiaging outcomes, but it reports no new clinical results.

This case report describes a 27-year-old man hospitalized with fatigue, myalgias, weakness, profound weight loss, and abnormal liver function, leading to a diagnosis after chest imaging revealed pneumomediastinum.

This study highlights that lower testosterone in men and higher testosterone in women are linked to increased risks of metabolic syndrome and type 2 diabetes, with associated skin diseases indicating potential cardiovascular complications.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

This review discusses various sex hormones and related compounds, including estrogens and anabolic steroids, but reports no new findings; it highlights existing literature from 2014 regarding their use and effects.

This review discusses sex differences in immune response to respiratory viral infections, including SARS-CoV-2, and highlights that hormones like estrogen may provide females with better protection, but it reports no new results.

This review covers cell transplantation methods for genitourinary reconstruction, discussing tissue sources and complications but presenting no new clinical findings.

This case report describes a rare instance of a patient with anorexia nervosa who was subsequently diagnosed with Cushing's syndrome, highlighting diagnostic challenges due to overlapping symptoms.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

This case report identifies an adolescent with symptoms indicative of Dunnigan-type partial lipodystrophy, emphasizing the need for early diagnosis to manage associated metabolic complications and improve self-esteem.

This review examines the role of oxidative stress in male hypogonadism associated with noncommunicable chronic diseases and discusses various management strategies, but it presents no new clinical findings.

This review discussed the variability in measuring serum testosterone levels and emphasized the need for standardizing testing and sharing updated treatment protocols to manage male hypogonadism effectively. It also highlighted the importance of considering secondary hypogonadism causes and suggested consulting with endocrinologists for optimal management.

This study indicated that while testosterone replacement in older men with low testosterone increases muscle mass and strength and reduces fat, its effects on physical function, disability, falls, or fractures remain unclear.

This review discusses various syndromes of severe insulin resistance, their biochemical and clinical features, and potential therapeutic options, but it reports no new clinical results.

This review discusses the advancements needed for gene therapy to become commonly used in dermatology and reports no new clinical results.

This review discusses the pathophysiology, diagnosis, and management of functional hypothalamic amenorrhea in adolescent girls and reports no new clinical results.

This review discusses the range and causes of adipose tissue diseases, emphasizing genetic and acquired forms of lipodystrophy, but it reports no new clinical results.

This article reviews current osteoporosis treatments, focusing on the potential of selective androgen receptor modulators and other agents to enhance bone formation, but provides no new clinical data.

In this review, researchers highlighted that natural polyphenolics like flavonoids and resveratrol may help enhance testosterone production in aging males by boosting the expression of the Star gene in Leydig cells, potentially preventing age-related degenerative conditions linked to testosterone insufficiency.

This review highlights the connection between sex hormones and metabolic dysfunction, emphasizing how conditions like male hypogonadism and female hyperandrogenism can increase the risk and severity of hepatic steatosis, which often progresses alongside metabolic syndrome and elevates mortality risks.

This study observed that testosterone therapy in transgender men enhances both physical and mental health, is safe in the short and middle term with proper follow-up, and highlights the need for endocrinologists to provide gender-affirming care despite its limited presence in medical education.