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    Glossary Langerhans cells

    specialized immune cells in the skin's outer layer

    Langerhans cells are specialized immune cells found in the skin's outer layer, the epidermis. They play a crucial role in detecting and presenting foreign substances to the immune system, helping to initiate an immune response. These cells are essential for skin health and protection against infections.

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    1. The Human Hair Follicle: A Reservoir of CD40+ B7-Deficient Langerhans Cells that Repopulate Epidermis After UVB Exposure 1998 · 99 citations
    2. New Aspects of Langerhans' Cell Function International Journal of Dermatology · 1980 · 57 citations
    3. Spatial relationship between Merkel cells and Langerhans cells in human hair follicles Journal of dermatological science · 2002 · 27 citations
    4. Wnt Signaling Influences the Development of Murine Epidermal Langerhans Cells Journal of Investigative Dermatology · 2011 · 18 citations
    5. Langerhans' Cells in Hair Follicles of the Depigmenting C57Bl/Ler-vit.vit Mouse Archives of Dermatology · 1987 · 11 citations
    6. Flexural Agminated Eruptive Nevi in Langerhans Cell Histiocytosis JAMA Dermatology · 2013 · 9 citations
    7. Changes in intraepidermal nerve fiber and Langerhans cell densities in the plantar skin of rats after mercuric chloride exposure Journal of the Peripheral Nervous System · 2017 · 6 citations
    8. At the Root: Cutaneous Langerhans Cell Histiocytosis The American Journal of Medicine · 2018 · 3 citations
    9. Langerhans' cells in hair follicles of the depigmenting C57Bl/Ler-vit.vit mouse. A model for human vitiligo Archives of Dermatology · 1987 · 2 citations
    10. Dendritic cell subsets in alopecia areata: focus on plasmacytoid dendritic cells and Langerhans cells in immune imbalance and therapeutic implications Expert Review of Clinical Immunology · 2026
    11. Three-dimensional analysis of intraepidermal nerve fibres and Langerhans cells in keloids with a focus on pruritus Scientific Reports · 2025
    12. 265 Loss of Langerhans cells in scar lesion of lichen planopilaris is caused by downregulation of integrin αvβ6 in the epidermal keratinocytes 2017
    13. Hair development and Langerhans cell migration during human embryogenesis Journal of dermatological science · 2012
    14. P130 The densities of T cells, Langerhans cells, and natural killer cells in uninvolved skin of patients with acne vulgaris Journal of the European Academy of Dermatology and Venereology · 1997
    15. Dyad of infantile cutaneous and thymic Langerhans cell histiocytosis: Is it rare? Pediatric blood & cancer · 2023
    16. The distribution of Langerhans cells within the human hair follicle, and some observations on its staining properties with gold chloride. PubMed · 1963 · 30 citations
    17. Expression of Langerhans cell antigens in the hair follicles in alopecia areata 1989
    18. Differentiating pulmonary lymphangioleiomyomatosis from pulmonary langerhans cell histiocytosis and Birt-Hogg-Dube syndrome Lung India · 2013 · 1 citations
    19. Comparison between low-dose chemotherapy and surgery for the treatment of extremity-associated solitary bone lesions in children with Langerhans cell histiocytosis in South China: A case-control study Journal of bone oncology · 2018 · 2 citations
    20. Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin Nature Immunology · 2012 · 286 citations
    21. Vitamin D receptor ablation alters skin architecture and homeostasis of dendritic epidermal T cells 2005 · 16 citations
    22. Eavesdropping on the conversation between immune cells and the skin epithelium International Immunology · 2019 · 10 citations
    23. Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 7 citations
    24. Human epidermal resident memory T cells: beyond the dermal perspective Frontiers in Immunology · 2026
    25. Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege International Journal of Cosmetic Science · 2024
    26. Generating detailed intercellular communication patterns in psoriasis at the single-cell level using social networking, pattern recognition, and manifold learning methods to optimize treatment strategies Aging · 2024
    27. 785 Single-cell transcriptomic profile of EGFR-deficient epidermal compartments during folliculitis 2023
    28. 035 Expansion of bacterial phosphatidylglycerol reactive CD4+ T cells in atopic dermatitis Journal of Investigative Dermatology · 2021
    29. 591 A New 3D Skin Model Containing Autologous Immune Cells Reconstructed by Tissue Engineering Journal of Investigative Dermatology · 2019
    30. 1337 Single cell transcriptome profiling of human interfollicular epidermis reveals robust heterogeneity and divergent differentiation lineages Journal of Investigative Dermatology · 2018