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    Glossary Keratin 5

    protein providing structural support in skin and hair follicles

    Keratin 5 (KRT5) is a type of protein found in the skin and hair follicles that helps provide structural support and strength. It is particularly important in the formation of the intermediate filaments in epithelial cells, which are cells that line the surfaces and cavities of the body. Mutations in the KRT5 gene can lead to skin disorders such as epidermolysis bullosa simplex, where the skin becomes fragile and blisters easily.

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    1. Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex International Journal of Molecular Sciences · 2021 · 40 citations
    2. Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice Journal of Biological Chemistry · 2014 · 15 citations
    3. Identification of somatic and germline mosaicism for a keratin 5 mutation in epidermolysis bullosa simplex in a family of which the proband was previously regarded as a sporadic case Clinical Genetics · 2004 · 26 citations
    4. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000 · 215 citations
    5. Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter Molecular Therapy · 2007 · 52 citations
    6. Keratins 6, 16, and 17 in Health and Disease: A Summary of Recent Findings Current Issues in Molecular Biology · 2024 · 37 citations
    7. The inconsistent regulation of HOXC13 on different keratins and the regulation mechanism on HOXC13 in cashmere goat (Capra hircus) BMC Genomics · 2018 · 17 citations
    8. Expression of epidermal keratins and filaggrin during human fetal skin development. The Journal of Cell Biology · 1985 · 292 citations
    9. Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins Scientific reports · 2018 · 54 citations
    10. Proliferating trichilemmal cyst with histological malignant transformation: Identification of hair sheath keratins in the tumor. The Nishinihon Journal of Dermatology · 1989 · 3 citations
    11. Faculty Opinions recommendation of The keratins of the human beard hair medulla: the riddle in the middle. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2010
    12. The human keratins: biology and pathology Histochemistry and Cell Biology · 2008 · 1398 citations
    13. Keratins in health and cancer: more than mere epithelial cell markers Oncogene · 2010 · 438 citations
    14. Keratins of the Human Hair Follicle International review of cytology · 2005 · 276 citations
    15. The Catalog of Human Hair Keratins 1999 · 235 citations
    16. Hair follicle-specific keratins and their diseases Experimental cell research · 2007 · 138 citations
    17. Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro Differentiation · 1987 · 135 citations
    18. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
    19. Keratins and disease at a glance Journal of Cell Science · 2012 · 87 citations
    20. Keratins and skin disease 2015 · 69 citations
    21. A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes<i>in vitro</i>and<i>in situ</i> PeerJ · 2013 · 66 citations
    22. Keratins and lipids in ethnic hair International Journal of Cosmetic Science · 2013 · 55 citations
    23. Skin Keratins 2015 · 54 citations
    24. Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle. PubMed · 1990 · 44 citations
    25. Immunohistochemical demonstration of keratins 8 and 14 in benign tumours of the skin appendage Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 1991 · 38 citations
    26. Convergent Evolution of Cysteine-Rich Keratins in Hard Skin Appendages of Terrestrial Vertebrates Molecular biology and evolution · 2019 · 36 citations
    27. Immunohistochemical demonstration of keratins in the epidermal layers of the Malayan pangolin (Manis javanica), with remarks on the evolution of the integumental scale armour European Journal of Histochemistry · 2013 · 28 citations
    28. The Proteins of Normal and Aberrant Hair Keratins 1981 · 23 citations
    29. Keratins: the hair shaft's backbone revealed Experimental Dermatology · 2015 · 17 citations
    30. The in vitro Assembly of Hair Follicle Keratins: Comparison of Cortex and Companion Layer Keratins Biological chemistry · 2002 · 13 citations