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    Glossary Keratin 19

    protein in epithelial cells used as a cancer biomarker

    Keratin 19 (KRT19 or CK19) is a type of protein found in the epithelial cells that line the surfaces and cavities of organs. It plays a crucial role in maintaining the structural integrity of these cells. In medical diagnostics, KRT19 is often used as a biomarker to detect certain types of cancers, as its expression levels can be indicative of tumor presence and progression.

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    1. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest it Evolved from Keratinocyte Keratins. Journal of Investigative Dermatology · 1989 · 238 citations
    2. The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1 Journal of Biological Chemistry · 2000 · 119 citations
    3. Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino-Acid Composition and Repeat Structure 2007 · 51 citations
    4. The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties Journal of Biological Chemistry · 1998 · 46 citations
    5. Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits Animals · 2019 · 7 citations
    6. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage Journal of Cell Science · 1996 · 441 citations
    7. Transient expression of keratin 19 is induced in originally negative interfollicular epidermal cells by adhesion of suspended cells. PubMed · 2005 · 25 citations
    8. Genomic Organization and Amplification of the Human Keratin 15 and Keratin 19 Genes Biochemical and Biophysical Research Communications · 2000 · 12 citations
    9. Characterization of Epithelial Hair Follicle Stem Cells in Lichen Planopilaris and Folliculitis Decalvans Through Keratin 19 Expression American Journal of Dermatopathology · 2025
    10. The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice Gastroenterology · 2001 · 66 citations
    11. Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes 1998 · 74 citations
    12. Differential expression of keratin 19 in normal human epithelial tissues revealed by monospecific monoclonal antibodies The Histochemical Journal · 1986 · 159 citations
    13. Immunohistochemical Demonstration of Keratin 19 Expression in Isolated Human Hair Follicles Journal of Investigative Dermatology · 1994 · 43 citations
    14. Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development Archives of Dermatological Research · 2013 · 19 citations
    15. Localization of Merkel cells at hairless and hairy human skin sites using keratin 18 Biochemistry and Cell Biology · 1995 · 28 citations
    16. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
    17. Tunable Keratin Hydrogels for Controlled Erosion and Growth Factor Delivery Biomacromolecules · 2015 · 106 citations
    18. Characterisation of an Ovine Keratin Associated Protein (KAP) Gene, Which Would Produce a Protein Rich in Glycine and Tyrosine, but Lacking in Cysteine Genes · 2019 · 24 citations
    19. Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression PloS one · 2016 · 14 citations
    20. The susceptibility of disulfide bonds to modification in keratin fibers undergoing tensile stress Biophysical Journal · 2022 · 11 citations
    21. Dendrobium officinale polysaccharide improves hair regrowth in androgenetic alopecia mice and is associated with coordinated changes in local steroid metabolism, ESR1 activation, and keratin-related follicular responses Frontiers in Pharmacology · 2026
    22. Telogen effluvium, Beau lines, and acral peeling associated with COVID-19 infection JAAD Case Reports · 2021 · 7 citations
    23. The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family PloS one · 2016 · 14 citations
    24. George Ernest Rogers 1927–2021 2023
    25. Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987 Clinical and Experimental Dermatology · 1989
    26. Scientific Opinion on the substantiation of a health claim related to KF2BL20 and maintenance of normal hair pursuant to Article 13(5) of Regulation (EC) No 1924/2006 EFSA journal · 2012 · 1 citations
    27. Strengthening hair growth Карр (Dent. med. Woch., 1921, №11) Kazanskij medicinskij žurnal · 2021
    28. The Developmental & Molecular Requirements for Ensuring that Human Pluripotent Stem Cell-Derived Hair Follicle Bulge Stem Cells Have Acquired Competence for Hair Follicle Generation Following Transplantation Cell transplantation · 2021 · 4 citations
    29. Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin Physiological Genomics · 2004 · 90 citations
    30. A Review: The Location, Molecular Characterisation and Multipotency of Hair Follicle Epidermal Stem Cells Annals of the Academy of Medicine Singapore · 2004 · 61 citations