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    Glossary Keratin-Associated Proteins

    bind to keratin fibers, strengthening hair and nails

    Keratin-Associated Proteins (KAPs) are a group of proteins that bind to keratin fibers, which are the structural components of hair, nails, and the outer layer of skin. They play a crucial role in the formation and strength of these keratin structures by cross-linking with keratin, thereby enhancing the rigidity and resilience of hair and other keratinized tissues.

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    1. Cornified Epithelial Teeth of Jawless Vertebrates Contain Proteins Similar to Keratin-Associated Proteins of Mammalian Skin Appendages Journal of Developmental Biology · 2025
    2. Isolation and Characterization of a Putative Keratin-Associated Protein Gene Expressed in Embryonic Skin of Mice Journal of Investigative Dermatology · 1998 · 22 citations
    3. The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein Journal of Biological Chemistry · 1993 · 161 citations
    4. Mammalian keratin associated proteins (KRTAPs) subgenomes: disentangling hair diversity and adaptation to terrestrial and aquatic environments BMC genomics · 2014 · 65 citations
    5. Keratin Gene Expression Differences in Wool Follicles and Sequence Diversity of High Glycine-Tyrosine Keratin-Associated Proteins (Kaps) in Magra Sheep of India Journal of Natural Fibers · 2018 · 9 citations
    6. Downregulation of mRNAs Encoding Keratin-Associated Proteins in the Tongue of Mice Fed a High-Fat Diet Journal of Hard Tissue Biology · 2024
    7. Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function Cell Death and Disease · 2015 · 17 citations
    8. Characterization of Human Keratin-Associated Protein 1 Family Members 2003 · 17 citations
    9. Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair BMC Evolutionary Biology · 2008 · 119 citations
    10. Polymorphisms in the Human High Sulfur Hair Keratin-associated Protein 1, KAP1, Gene Family 2002 · 48 citations
    11. The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes International journal of molecular sciences · 2021 · 10 citations
    12. Highly Conserved Keratin-Associated Protein 7-1 Gene in Yak, Taurine and Zebu Cattle Folia biologica · 2017 · 2 citations
    13. Distribution of keratin and associated proteins in the epidermis of monotreme, marsupial, and placental mammals Journal of Morphology · 2003 · 21 citations
    14. Identification and sequence analysis of the keratin-associated protein 24‐1 (KAP24-1) gene homologue in sheep Gene · 2012 · 51 citations
    15. Isolation and characterization of genomic clones of human sequences presumably coding for hair cysteine-rich proteins Journal of Dermatological Science · 1997 · 11 citations
    16. Symposium Proceedings of the 4th Intercontinental Meeting of Hair Research Societies: “The World of Hair 2004” Journal of Investigative Dermatology Symposium Proceedings · 2005
    17. Thermal and mechanical transitions in keratins and their relevance for hair cosmetics 2006 · 1 citations
    18. The structure of the “amorphous” matrix of keratins Journal of structural biology · 2017 · 30 citations
    19. Characterisation of low abundance wool proteins through novel differential extraction techniques Electrophoresis · 2010 · 26 citations
    20. Mapping the accessibility of the disulfide crosslink network in the wool fiber cortex Proteins Structure Function and Bioinformatics · 2014 · 22 citations
    21. Keratin 2016 · 6 citations
    22. Fundamental hair follicle biology and fine fibre production in animals animal · 2010 · 170 citations
    23. The human hair: from anatomy to physiology International Journal of Dermatology · 2013 · 107 citations
    24. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations
    25. Discovery of differentially expressed genes in cashmere goat (Capra hircus) hair follicles by RNA sequencing Genetics and Molecular Research · 2016 · 5 citations
    26. Unexpected Autocrine Role of Vascular Endothelial Growth Factor in Squamous Cell Carcinoma Journal of Investigative Dermatology · 2009 · 1 citations
    27. Bioinformatics analysis of EST segment from goat China Journal of Bioinformatics · 2008 · 1 citations
    28. Hair follicle transcriptome profiles during the transition from anagen to catagen in Cashmere goat (Capra hircus) Genetics and molecular research · 2015 · 14 citations
    29. Trichothiodystrophy hair shafts display distinct ultrastructural features Experimental dermatology · 2022
    30. Embryonic keratinization in vertebrates in relation to land colonization Acta Zoologica · 2008 · 44 citations