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    Glossary Keratin 6

    protein in skin, hair, and nails providing structural support

    Keratin 6 (K6) is a type of protein found in the epithelial cells of the skin, hair, and nails. It plays a crucial role in the structural integrity and resilience of these tissues. Mutations in the KRT6 gene, which encodes Keratin 6, can lead to disorders such as pachyonychia congenita, characterized by thickened nails and other skin abnormalities.

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    1. Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation 2014 · 32 citations
    2. Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development British Journal of Dermatology · 1999 · 19 citations
    3. Histopathological Analysis on keratin2-6 g Expression in Hair Mutant Mouse Hague Proceedings of The Japanese Society of Animal Models for Human Diseases · 2002
    4. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle Journal of Investigative Dermatology · 2006 · 93 citations
    5. The human keratins: biology and pathology Histochemistry and Cell Biology · 2008 · 1398 citations
    6. The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain Differentiation · 2004 · 70 citations
    7. A Homozygous Missense Variant in K25 Underlying Overlapping Phenotype with Woolly Hair and Dental Anomalies 2022 · 2 citations
    8. Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals Molecular Biology and Evolution · 2018 · 68 citations
    9. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 2001 · 98 citations
    10. Ultrastructural localization of hair keratins, high sulfur keratin-associated proteins and sulfhydryl oxidase in the human hair Anatomical Science International · 2016 · 9 citations
    11. Effects of FGF5-mediated LncRNA on the skin fibroblast growth of Liaoning Cashmere goats Indian Journal of Animal Health · 2023
    12. A Missense Mutation within the Helix Termination Motif of KRT25 Causes Autosomal Dominant Woolly Hair/Hypotrichosis Journal of Investigative Dermatology · 2017 · 33 citations
    13. Corneal epithelial‐like transdifferentiation of hair follicle stem cells is mediated by pax6 and β‐catenin/Lef‐1 Cell Biology International · 2009 · 20 citations
    14. Regulation of a hair follicle keratin intermediate filament gene promoter Journal of Cell Science · 1998 · 39 citations
    15. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 1999 · 53 citations
    16. Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes Journal of Cellular Biochemistry · 2015 · 40 citations
    17. Keratin disorders: from gene to therapy 2011 · 109 citations
    18. Types I and II Keratin Intermediate Filaments Cold Spring Harbor Perspectives in Biology · 2018 · 211 citations
    19. A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes & Development · 1989 · 156 citations
    20. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013 · 85 citations
    21. Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert. 2004 · 62 citations
    22. Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration Development · 2013 · 60 citations
    23. Convergent Evolution of Cysteine-Rich Keratins in Hard Skin Appendages of Terrestrial Vertebrates Molecular biology and evolution · 2019 · 36 citations
    24. Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases? BioEssays · 2014 · 26 citations
    25. Association analysis of polymorphisms in six keratin genes with wool traits in sheep Asian-Australasian journal of animal sciences · 2017 · 17 citations
    26. The inconsistent regulation of HOXC13 on different keratins and the regulation mechanism on HOXC13 in cashmere goat (Capra hircus) BMC Genomics · 2018 · 17 citations
    27. <i>In vitro</i> Assembly Properties of Human Type I and II Hair Keratins Cell structure and function · 2014 · 12 citations
    28. Anti-keratin Monoclonal Antibodies for Identifying Animal Hair Fibers Textile Research Journal · 2004 · 8 citations
    29. Keratin function and regulation in tissue homeostasis and pathogenesis Biomolecular concepts · 2012 · 7 citations
    30. Exploring the effects of wetting and free fatty acid deposition on an atomistic hair fiber surface model incorporating Keratin Associated Protein 5-1 2022