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    Glossary Keratin 10

    protein crucial for skin's structural integrity and resilience

    Keratin 10 (KRT10) is a type of protein found in the upper layers of the skin, specifically in the epidermis. It plays a crucial role in maintaining the structural integrity and resilience of the skin by forming a network of intermediate filaments that provide mechanical support. Mutations in the KRT10 gene can lead to skin disorders such as epidermolytic hyperkeratosis, which is characterized by blistering and thickening of the skin.

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    1. Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation 2014 · 32 citations
    2. Clinicopathological features and expression of four keratins (K10, K14, K17 and K19) in six cases of eruptive vellus hair cysts Clinical and Experimental Dermatology · 2014 · 8 citations
    3. Severe Abnormalities in the Oral Mucosa Induced by Suprabasal Expression of Epidermal Keratin K10 in Transgenic Mice Journal of Biological Chemistry · 2002 · 15 citations
    4. Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than the expression of K1 and K10. PubMed · 1994 · 13 citations
    5. KERATINS AND SKIN DISORDERS Cell biology international · 1996 · 28 citations
    6. Genetic disorders of keratin: are scarring alopecias a sub-set? Journal of Dermatological Science · 1994 · 14 citations
    7. An unexpected role for keratin 10 end domains in susceptibility to skin cancer Journal of Cell Science · 2006 · 43 citations
    8. Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation European journal of cell biology · 2004 · 36 citations
    9. Keratin expression in the normal nail unit: markers of regional differentiation British Journal of Dermatology · 2000 · 119 citations
    10. Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals Molecular Biology and Evolution · 2018 · 68 citations
    11. Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle. PubMed · 1990 · 44 citations
    12. Biochemical and immunohistochemical analyses of keratin expression in basal cell carcinoma Journal of Dermatological Science · 1998 · 37 citations
    13. Development, Structure, and Keratin Expression in <i>C57BL/6J</i> Mouse Eccrine Glands Veterinary pathology · 2011 · 29 citations
    14. Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development British Journal of Dermatology · 1999 · 19 citations
    15. Epithelial keratin and filaggrin expression in seborrheic keratosis: evaluation based on histopathological classification International Journal of Dermatology · 2013 · 12 citations
    16. A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11 Genomics · 1989 · 49 citations
    17. Study on the distribution of hair keratin in normal hair follicles by immunohistochemical staining Acta Academiae Medicine Militaris Tertiae · 2000
    18. Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed British Journal of Dermatology · 2004 · 110 citations
    19. Reply to: The ends of a conundrum? Journal of Cell Science · 2007
    20. Milia may originate from the outermost layers of the hair bulge of the outer root sheath: A case report Oncology Letters · 2016
    21. A Heritable Keratinization Defect of the Superficial Epidermis in Norfolk Terriers Journal of Comparative Pathology · 2004 · 11 citations
    22. Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge Experimental Dermatology · 2009 · 18 citations
    23. Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10. PubMed · 1994 · 33 citations
    24. Complete Structure of an Epithelial Keratin Dimer: Implications for Intermediate Filament Assembly PLoS ONE · 2015 · 42 citations
    25. Characterization of the Human Hair Shaft Cuticle–Specific Keratin-Associated Protein 10 Family Journal of Investigative Dermatology · 2013 · 11 citations
    26. Histogenesis of keratoacanthoma: histochemical and immunohistochemical study Oral surgery, oral medicine, oral pathology and oral radiology · 2014 · 16 citations
    27. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 1999 · 53 citations
    28. The human keratins: biology and pathology Histochemistry and Cell Biology · 2008 · 1398 citations
    29. Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes Journal of Cellular Biochemistry · 2015 · 40 citations
    30. Keratin‐based particles for protection and restoration of hair properties International Journal of Cosmetic Science · 2018 · 17 citations