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    Glossary Keratin 6

    protein in skin, hair, and nails providing structural support

    Keratin 6 (K6) is a type of protein found in the epithelial cells of the skin, hair, and nails. It plays a crucial role in the structural integrity and resilience of these tissues. Mutations in the KRT6 gene, which encodes Keratin 6, can lead to disorders such as pachyonychia congenita, characterized by thickened nails and other skin abnormalities.

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    1. Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles Journal of Investigative Dermatology · 2003 · 60 citations
    2. Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin Physiological Genomics · 2004 · 90 citations
    3. Expression of Keratin 75 (K6hf) in Oral Squamous Cell Carcinoma Dental Medicine Research · 2011 · 2 citations
    4. The human keratins: biology and pathology Histochemistry and Cell Biology · 2008 · 1398 citations
    5. The Chicken Frizzle Feather Is Due to an α-Keratin (KRT75) Mutation That Causes a Defective Rachis PLoS Genetics · 2012 · 99 citations
    6. UNCONVENTIONAL PROTEIN SECRETION OF KERATIN 75 BY AMELOBLASTS IN VIVO D-Scholarship@Pitt (University of Pittsburgh) · 2018
    7. Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile ˜The œFASEB journal · 2007 · 45 citations
    8. Keratin Expression Provides Novel Insight into the Morphogenesis and Function of the Companion Layer in Hair Follicles Journal of Investigative Dermatology · 2006 · 38 citations
    9. Hedgehog Signaling, Keratin 6 Induction, and Sebaceous Gland Morphogenesis American Journal Of Pathology · 2008 · 33 citations
    10. Loose anagen hair syndrome in two patients with epidermolysis bullosa simplex, Dowling-Meara type Journal of the American Academy of Dermatology · 2012 · 2 citations
    11. A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue Journal of Investigative Dermatology · 2004 · 31 citations
    12. Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes Journal of Investigative Dermatology · 2004 · 49 citations
    13. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle Journal of Investigative Dermatology · 2006 · 93 citations
    14. Novel Type I Hair Keratins K39 and K40 Are the Last to be Expressed in Differentiation of the Hair: Completion of the Human Hair Keratin Catalog Journal of Investigative Dermatology · 2007 · 70 citations
    15. Integrated Meta-Analysis of Scalp Transcriptomics and Serum Proteomics Defines Alopecia Areata Subtypes and Core Disease Pathways International Journal of Molecular Sciences · 2025
    16. p53 Involvement in the Control of Murine Hair Follicle Regression American Journal of Pathology · 2001 · 71 citations
    17. Loose anagen syndrome in one identical twin girl Dermatology online journal · 2021
    18. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002 · 146 citations
    19. Hair regrowth in a male patient with extensive androgenetic alopecia on estrogen therapy Journal of The American Academy of Dermatology · 2012 · 18 citations
    20. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    21. Distinguishing Mouse Strains by Proteomic Analysis of Pelage Hair Journal of Investigative Dermatology · 2009 · 34 citations
    22. Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis Genes · 2020 · 7 citations
    23. Dietary Vitamin A Impacts Refractory Telogen Frontiers in Cell and Developmental Biology · 2021 · 6 citations
    24. Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality 2010 · 46 citations
    25. A Two-Stepped Culture Method for Efficient Production of Trichogenic Keratinocytes Tissue Engineering Part C-methods · 2015 · 16 citations
    26. Transplanted hair follicle stem cells migrate to the penumbra and express neural markers in a rat model of cerebral ischaemia/reperfusion Stem Cell Research & Therapy · 2020 · 31 citations
    27. Traditional Chinese Medicine Shi-Bi-Man regulates lactic acid metabolism and drives hair follicle stem cell activation to promote hair regeneration Chinese Medicine · 2023 · 1 citations
    28. ‘Hard’ and ‘soft’ principles defining the structure, function and regulation of keratin intermediate filaments Current Opinion in Cell Biology · 2002 · 686 citations
    29. A Review of Keratin-Based Biomaterials for Biomedical Applications Materials · 2010 · 517 citations
    30. Keratin cytoskeletons in epithelial cells of internal organs Proceedings of the National Academy of Sciences · 1979 · 482 citations