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    Glossary Keratin 6

    protein in skin, hair, and nails providing structural support

    Keratin 6 (K6) is a type of protein found in the epithelial cells of the skin, hair, and nails. It plays a crucial role in the structural integrity and resilience of these tissues. Mutations in the KRT6 gene, which encodes Keratin 6, can lead to disorders such as pachyonychia congenita, characterized by thickened nails and other skin abnormalities.

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    1. Delayed Wound Healing in Keratin 6a Knockout Mice Molecular and Cellular Biology · 2000 · 149 citations
    2. Defining a Region of the Human Keratin 6a Gene That Confers Inducible Expression in Stratified Epithelia of Transgenic Mice Journal of Biological Chemistry · 1997 · 44 citations
    3. Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes Journal of Biomedical Science · 2025 · 7 citations
    4. Madarosis and facial keratinaceous spines JAAD case reports · 2023
    5. Hedgehog Signaling, Keratin 6 Induction, and Sebaceous Gland Morphogenesis American Journal Of Pathology · 2008 · 33 citations
    6. Polymorphisms in the Human High Sulfur Hair Keratin-associated Protein 1, KAP1, Gene Family 2002 · 48 citations
    7. Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle Differentiation · 1999 · 30 citations
    8. A new type of pachyonychia congenita. PubMed · 2001 · 10 citations
    9. Painful thickened skin on the soles of the feet JAAD case reports · 2022
    10. Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice Mechanisms of development · 2005 · 63 citations
    11. Malassezia (Pityrosporon) Folliculitis Occurring During Pregnancy International Journal of Dermatology · 1986 · 28 citations
    12. Is Propionibacterium acnes associated with hair casts and alopecia? International Journal of Trichology · 2012 · 19 citations
    13. Insertional mutation of the hairless locus on mouse Chromosome 14 Mammalian Genome · 1993 · 19 citations
    14. Pathogenicity and enzyme screening of some selected non-dermatophytic moulds Access Microbiology · 2024 · 1 citations
    15. An Integrated Two-Step Enzymatic Unhairing Strategy: Eliminating the Penetration Barrier via Soaking To Enhance Targeted Protease Action Industrial & Engineering Chemistry Research · 2026
    16. The Use of Keratin Hydrolysate Obtained by Microbial Conversion of Chicken Feathers as Part of a Cosmetic Serum for Hair Care Health Food & Biotechnology · 2026
    17. Production and characterization of human hair keratin bioplastic films with novel plasticizers Scientific reports (Nature Publishing Group) · 2024 · 1 citations
    18. A Splice Site Mutation in the Gene of the Human Type I Hair Keratin hHa1 Results in the Expression of a Tailless Keratin Isoform Journal of Biological Chemistry · 1997 · 28 citations
    19. Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay PLoS Genetics · 2018 · 21 citations
    20. The human keratins: biology and pathology Histochemistry and Cell Biology · 2008 · 1398 citations
    21. Defining the complex epithelia that comprise the canine claw with molecular markers of differentiation Veterinary Dermatology · 2009 · 6 citations
    22. Variation in the ovine keratin-associated protein 15-1 gene affects wool yield The Journal of Agricultural Science · 2018 · 18 citations
    23. A curated catalog of canine and equine keratin genes PLoS ONE · 2017 · 20 citations
    24. Hair keratin film as a substitute device for human hair Journal of Biological Macromolecules · 2012 · 10 citations
    25. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 1999 · 53 citations
    26. Is thyrotropin-releasing hormone a novel neuroendocrine modulator of keratin expression in human skin? British Journal of Dermatology · 2013 · 10 citations
    27. Expression of Keratin 75 (K6hf) in Oral Squamous Cell Carcinoma Dental Medicine Research · 2011 · 2 citations
    28. Keratin 17 modulates hair follicle cycling in a TN<i>Fα</i>-dependent fashion Genes & Development · 2006 · 169 citations
    29. A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes & Development · 1989 · 156 citations
    30. Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes & Development · 1992 · 150 citations