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    Glossary Keratin 1

    protein providing structural support in skin cells

    Keratin 1 (KRT1) is a type of protein found in the outer layer of the skin, playing a crucial role in providing structural integrity and resilience. It partners with Keratin 10 to form intermediate filaments, which help skin cells withstand mechanical stress and prevent damage. Mutations in the KRT1 gene can lead to skin disorders such as epidermolytic hyperkeratosis, characterized by blistering and thickened skin.

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    1. Localization of Merkel cells at hairless and hairy human skin sites using keratin 18 Biochemistry and Cell Biology · 1995 · 28 citations
    2. The relationship between keratin 18 and epithelial-derived tumors: as a diagnostic marker, prognostic marker, and its role in tumorigenesis Frontiers in Oncology · 2024
    3. Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino-Acid Composition and Repeat Structure 2007 · 51 citations
    4. Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling PloS one · 2012 · 35 citations
    5. Variation in the caprine keratin-associated protein 15-1 (KAP15-1) gene affects cashmere fibre diameter 2019 · 30 citations
    6. Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits Animals · 2019 · 7 citations
    7. Stable isotope analyses of carbon and nitrogen in hair keratin of suspected man-eating wolves from 1880s Scientific Reports · 2024
    8. Abstract 5022: Keratin15 (Krt15) + are radio resistant and tumor-initiating cells in the mouse small intestine Cancer Research · 2017
    9. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
    10. Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity Advanced Science · 2023
    11. Tunable Keratin Hydrogels for Controlled Erosion and Growth Factor Delivery Biomacromolecules · 2015 · 106 citations
    12. Characterisation of an Ovine Keratin Associated Protein (KAP) Gene, Which Would Produce a Protein Rich in Glycine and Tyrosine, but Lacking in Cysteine Genes · 2019 · 24 citations
    13. Chronological ageing of human hair keratin fibres International Journal of Cosmetic Science · 2010 · 49 citations
    14. Solitary pedunculated multicystic viral plaque associated with canine papillomavirus 18 in a British Bulldog Journal of veterinary diagnostic investigation · 2022 · 1 citations
    15. Exploring the effects of wetting and free fatty acid deposition on an atomistic hair fiber surface model incorporating Keratin Associated Protein 5-1 2022
    16. Peer Review #2 of "Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis (v0.1)" 2014
    17. The Developmental & Molecular Requirements for Ensuring that Human Pluripotent Stem Cell-Derived Hair Follicle Bulge Stem Cells Have Acquired Competence for Hair Follicle Generation Following Transplantation Cell transplantation · 2021 · 4 citations
    18. Establishment and molecular characterization of human dermal mesenchymal-like stem cells derived from human scalp biopsy of androgenetic alopecia patient Stem cell discovery · 2013 · 4 citations
    19. Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin Physiological Genomics · 2004 · 90 citations
    20. An immunohistochemical study of the apocrine type of cutaneous mixed tumors with special reference to their follicular and sebaceous differentiation Journal of Cutaneous Pathology · 1999 · 54 citations
    21. Enhanced cutaneous wound healing by functional injectable thermo-sensitive chitosan-based hydrogel encapsulated human umbilical cord-mesenchymal stem cells International Journal of Biological Macromolecules · 2019 · 48 citations
    22. The sheep KAP8-2 gene, a new KAP8 family member that is absent in humans SpringerPlus · 2014 · 25 citations
    23. 545 Skin Organoids derived from NCSTN mutated patient-induced pluripotent stem cells recapitulate Hidradenitis Suppurativa pathogenic hallmarks 2022
    24. Correlation analysis of four KRTAP gene polymorphisms and cashmere fiber diameters in two cashmere goat breeds Canadian journal of animal science · 2022
    25. Investigation of the damage on the outermost hair surface using ToF‐SIMS and XPS Surface and interface analysis · 2011 · 25 citations
    26. Lineage Tracing of Hair Follicle Stem Cells in Epidermal Whole Mounts Methods in molecular biology · 2013 · 11 citations
    27. Deletion of the <i>Sox21</i> gene drastically affects hair lipids Experimental Dermatology · 2012 · 2 citations
    28. ATOMISTIC CHARACTERIZATION OF HEALTHY AND DAMAGED HAIR SURFACES: A MOLECULAR DYNAMICS STUDY OF FATTY ACIDS ON PROTEIN LAYER ChemBioChem · 2024
    29. Corneal epithelial‐like transdifferentiation of hair follicle stem cells is mediated by pax6 and β‐catenin/Lef‐1 Cell Biology International · 2009 · 20 citations
    30. 186 Dissecting the role of the common neurotrophin receptor CD271 in the skin: generation and characterization of a novel mouse model with keratinocyte-specific conditional deletion 2022