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    Glossary Keratin 10

    protein crucial for skin's structural integrity and resilience

    Keratin 10 (KRT10) is a type of protein found in the upper layers of the skin, specifically in the epidermis. It plays a crucial role in maintaining the structural integrity and resilience of the skin by forming a network of intermediate filaments that provide mechanical support. Mutations in the KRT10 gene can lead to skin disorders such as epidermolytic hyperkeratosis, which is characterized by blistering and thickening of the skin.

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    1. An unexpected role for keratin 10 end domains in susceptibility to skin cancer Journal of Cell Science · 2006 · 43 citations
    2. Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation European journal of cell biology · 2004 · 36 citations
    3. Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10. PubMed · 1994 · 33 citations
    4. A new heterozygous frameshift variant in keratin 10 resulting in ichthyosis hystrix in a father and daughter JAAD case reports · 2023
    5. Histological features of melasma lesions and the expression of keratin 10 Chinese Journal of Aesthetic Medicine · 2010
    6. Variation in the caprine keratin-associated protein 15-1 (KAP15-1) gene affects cashmere fibre diameter 2019 · 30 citations
    7. Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits Animals · 2019 · 7 citations
    8. Exploring the effects of wetting and free fatty acid deposition on an atomistic hair fiber surface model incorporating Keratin Associated Protein 5-1 2022
    9. Characterization of the Human Hair Shaft Cuticle–Specific Keratin-Associated Protein 10 Family Journal of Investigative Dermatology · 2013 · 11 citations
    10. Polymorphisms in the Human High Sulfur Hair Keratin-associated Protein 1, KAP1, Gene Family 2002 · 48 citations
    11. Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle. PubMed · 1990 · 44 citations
    12. Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits Genes · 2017 · 29 citations
    13. Abstract 5022: Keratin15 (Krt15) + are radio resistant and tumor-initiating cells in the mouse small intestine Cancer Research · 2017
    14. Re: “Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial” by Tenore <i>et al.</i> (<i>J Med Food</i> 2018;21:90–103) Journal of Medicinal Food · 2019 · 2 citations
    15. Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix Journal of Investigative Dermatology · 2001 · 130 citations
    16. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    17. Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development British Journal of Dermatology · 1999 · 19 citations
    18. Histologic morphology and involucrin, filaggrin, and keratin expression in normal canine skin from dogs of different breeds and coat types Journal of Veterinary Science · 2012 · 15 citations
    19. The susceptibility of disulfide bonds to modification in keratin fibers undergoing tensile stress Biophysical Journal · 2022 · 11 citations
    20. Alkylation of human hair keratin for tunable hydrogel erosion and drug delivery in tissue engineering applications Acta biomaterialia · 2015 · 75 citations
    21. Characterisation of an Ovine Keratin Associated Protein (KAP) Gene, Which Would Produce a Protein Rich in Glycine and Tyrosine, but Lacking in Cysteine Genes · 2019 · 24 citations
    22. Epithelial keratin and filaggrin expression in seborrheic keratosis: evaluation based on histopathological classification International Journal of Dermatology · 2013 · 12 citations
    23. Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy International journal of trichology · 2010 · 10 citations
    24. Hair growth promoting activity of discarded biocomposite keratin extract Journal of Biomaterials Applications · 2017 · 3 citations
    25. Enhanced substantivity of hyaluronic acid on keratin substrates via polymer complexation International Journal of Cosmetic Science · 1994 · 2 citations
    26. Dendrobium officinale polysaccharide improves hair regrowth in androgenetic alopecia mice and is associated with coordinated changes in local steroid metabolism, ESR1 activation, and keratin-related follicular responses Frontiers in Pharmacology · 2026
    27. Development and optimization of biotinoyl tripeptide-1 loaded solid lipid nanoparticles for protection against heat induced hair damage DergiPark (Istanbul University) · 2026
    28. 1322 Molecular profiling of frontal fibrosing alopecia (FFA) reveals TH1 and JAK-STAT up-regulation with no suppression of hair keratins Journal of Investigative Dermatology · 2018 · 2 citations
    29. Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo eLife · 2023 · 23 citations
    30. FORMATION OF A REGULAR NEO-EPIDERMIS BY CULTURED HUMAN OUTER ROOT SHEATH CELLS GRAFTED ON NUDE MICE Transplantation · 1995 · 14 citations