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    Glossary JAK2 inhibitor

    blocks enzyme activity to regulate immune function and cell growth

    A JAK2 inhibitor is a type of medication that blocks the activity of Janus kinase 2 (JAK2), an enzyme involved in the signaling pathways that regulate immune function and cell growth. By inhibiting JAK2, these drugs can help manage conditions like certain cancers, autoimmune diseases, and inflammatory disorders, and they are also being explored for treating alopecia areata, a condition that causes hair loss.

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    Research 30 of 578

    1. Under Development JAK Inhibitors for Dermatologic Diseases Mediterranean Journal of Rheumatology · 2020 · 14 citations
    2. Tofacitinib: The selected selective JAK inhibitor in paediatric dermatology International Journal of Dermatology Venereology and Leprosy Sciences · 2024
    3. Which is the ideal JAK inhibitor for alopecia areata – Baricitinib, tofacitinib, ritlecitinib or ifidancitinib - Revisiting the immunomechanisms of the JAK pathway Indian Dermatology Online Journal · 2023
    4. Jak inhibitors in the treatment of alopecia areata - a literature review Journal of Education Health and Sport · 2025
    5. A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021 · 40 citations
    6. Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients 2018 · 15 citations
    7. 51840 Efficacy of the Oral JAK1/JAK2 Inhibitor Deuruxolitinib in Adult Patients with Moderate to Severe Alopecia Areata: Pooled Results from the Multinational Double-Blind, Placebo-Controlled THRIVE-AA1 and THRIVE-AA2 Phase 3 Trials Journal of the American Academy of Dermatology · 2024 · 2 citations
    8. 41701 Efficacy of the Oral JAK1/JAK2 Inhibitor CTP-543 (Deuruxolitinib) in Adult Patients with Moderate to Severe Alopecia Areata: Results from the Multinational Double-Blind, Placebo-Controlled THRIVE-AA1 Phase 3 Trial Journal of the American Academy of Dermatology · 2023 · 2 citations
    9. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    10. IN-SILICO STUDY OF BIOACTIVE COMPOUNDS OF NATURAL MATERIALS AS A JAK- SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION INHIBITOR FOR ANTI-ALOPECIA Asian journal of pharmaceutical and clinical research · 2017
    11. Janus Kinase inhibitors in dermatology: a review Portuguese Journal of Dermatology and Venereology · 2023 · 1 citations
    12. The development of oral hairy leukoplakia during JAK inhibitor baricitinib therapy JAAD case reports · 2023
    13. Clinical evidence for JAK inhibition in alopecia areata: A comprehensive review 2026
    14. Small Molecule Inhibitors and Inflammatory Skin Diseases Suez Canal University Medical Journal · 2018
    15. Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata JCI insight · 2021 · 42 citations
    16. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    17. 695 Selectively targeting JAK1 or JAK3 pathway is sufficient to reverse alopecia areata 2019
    18. Janus kinase inhibition for the treatment of refractory frontal fibrosing alopecia: A case series and review of the literature JAAD Case Reports · 2023 · 16 citations
    19. Combination Therapy with Baricitinib and Narrowband Ultraviolet B for Active Non-Segmental Vitiligo: A Retrospective Controlled Study Clinical Cosmetic and Investigational Dermatology · 2024 · 4 citations
    20. Real‐world experience and long‐term evaluation of tofacitinib in refractory alopecia areata: A prospective, open‐label, single‐center study in Asian Arab population Dermatologic Therapy · 2022 · 2 citations
    21. Off‐Label Use of Topical Ruxolitinib in Dermatology: A Systematic Literature Review and Current Perspectives Experimental Dermatology · 2025 · 1 citations
    22. Efficacy of Baricitinib in Patients with Various Degrees of Alopecia Areata Severity: Post-Hoc Analysis from BRAVE AA1 and BRAVE AA2 Dermatology and Therapy · 2023 · 1 citations
    23. Pharmacological Treatment of Alopecia InTech eBooks · 2018 · 1 citations
    24. JAK Family Expression and Therapeutic Implications in Primary Cicatricial Alopecias International Journal of Dermatology · 2025
    25. Efficacy and safety of baricitinib in patients with alopecia areata: evidence to date Drugs in context · 2023
    26. Baricitinib Demonstrates Rapid Action Within Just 2 Months of Treatment in Severe and Unresponsive Alopecia Areata: A Case Report 2024
    27. 42736 Safety Assessments in the Multinational Phase 3 THRIVE-AA1 Trial with CTP-543 (Deuruxolitinib) in Adult Patients with Moderate to Severe Alopecia Areata Journal of the American Academy of Dermatology · 2023
    28. P64 Efficacy of baricitinib in patients with different degrees of severe alopecia areata: 52-week results from BRAVE-AA1 and BRAVE-AA2 British Journal of Dermatology · 2023
    29. Two cases of alopecia areata treated with ruxolitinib: a discussion of ideal dosing and laboratory monitoring International Journal of Dermatology · 2017 · 25 citations
    30. Treatment of moderate-to-severe alopecia areata in pre-adolescent children with baricitinib British Journal of Dermatology · 2023 · 17 citations