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    Glossary JAK2 inhibitor

    blocks enzyme activity to regulate immune function and cell growth

    A JAK2 inhibitor is a type of medication that blocks the activity of Janus kinase 2 (JAK2), an enzyme involved in the signaling pathways that regulate immune function and cell growth. By inhibiting JAK2, these drugs can help manage conditions like certain cancers, autoimmune diseases, and inflammatory disorders, and they are also being explored for treating alopecia areata, a condition that causes hair loss.

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    Research 30 of 585

    1. Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature Journal of Dermatological Treatment · 2016 · 40 citations
    2. Under Development JAK Inhibitors for Dermatologic Diseases Mediterranean Journal of Rheumatology · 2020 · 14 citations
    3. Tofacitinib: The selected selective JAK inhibitor in paediatric dermatology International Journal of Dermatology Venereology and Leprosy Sciences · 2024
    4. Which is the ideal JAK inhibitor for alopecia areata – Baricitinib, tofacitinib, ritlecitinib or ifidancitinib - Revisiting the immunomechanisms of the JAK pathway Indian Dermatology Online Journal · 2023
    5. A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021 · 40 citations
    6. Jak inhibitors in the treatment of alopecia areata - a literature review Journal of Education Health and Sport · 2025
    7. 51840 Efficacy of the Oral JAK1/JAK2 Inhibitor Deuruxolitinib in Adult Patients with Moderate to Severe Alopecia Areata: Pooled Results from the Multinational Double-Blind, Placebo-Controlled THRIVE-AA1 and THRIVE-AA2 Phase 3 Trials Journal of the American Academy of Dermatology · 2024 · 2 citations
    8. 41701 Efficacy of the Oral JAK1/JAK2 Inhibitor CTP-543 (Deuruxolitinib) in Adult Patients with Moderate to Severe Alopecia Areata: Results from the Multinational Double-Blind, Placebo-Controlled THRIVE-AA1 Phase 3 Trial Journal of the American Academy of Dermatology · 2023 · 2 citations
    9. The development of oral hairy leukoplakia during JAK inhibitor baricitinib therapy JAAD case reports · 2023
    10. IN-SILICO STUDY OF BIOACTIVE COMPOUNDS OF NATURAL MATERIALS AS A JAK- SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION INHIBITOR FOR ANTI-ALOPECIA Asian journal of pharmaceutical and clinical research · 2017
    11. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    12. Clinical evidence for JAK inhibition in alopecia areata: A comprehensive review 2026
    13. Janus Kinase inhibitors in dermatology: a review Portuguese Journal of Dermatology and Venereology · 2023 · 1 citations
    14. Small Molecule Inhibitors and Inflammatory Skin Diseases Suez Canal University Medical Journal · 2018
    15. Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata JCI insight · 2021 · 42 citations
    16. Two cases of alopecia areata treated with ruxolitinib: a discussion of ideal dosing and laboratory monitoring International Journal of Dermatology · 2017 · 25 citations
    17. Treatment of moderate-to-severe alopecia areata in pre-adolescent children with baricitinib British Journal of Dermatology · 2023 · 17 citations
    18. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    19. 33766 Efficacy of baricitinib in patients with various degrees of alopecia areata severity: Results from BRAVE-AA1 and BRAVE-AA2 Journal of The American Academy of Dermatology · 2022 · 4 citations
    20. LB785 Efficacy and safety of baricitinib in adults with Alopecia Areata: Phase 3 results from a randomized controlled trial (BRAVE-AA1) Journal of Investigative Dermatology · 2021 · 3 citations
    21. Off‐Label Use of Topical Ruxolitinib in Dermatology: A Systematic Literature Review and Current Perspectives Experimental Dermatology · 2025 · 1 citations
    22. Efficacy of Baricitinib in Patients with Various Degrees of Alopecia Areata Severity: Post-Hoc Analysis from BRAVE AA1 and BRAVE AA2 Dermatology and Therapy · 2023 · 1 citations
    23. 44096 Efficacy in Subgroups related to Disease Characteristics in Patients with Alopecia Areata from BRAVE-AA1 and BRAVE-AA2 Journal of the American Academy of Dermatology · 2023 · 1 citations
    24. 33774 Baricitinib results in eyebrow and eyelash growth in patients with alopecia areata who do not achieve 20% or less scalp hair loss Journal of The American Academy of Dermatology · 2022 · 1 citations
    25. Baricitinib Demonstrates Rapid Action Within Just 2 Months of Treatment in Severe and Unresponsive Alopecia Areata: A Case Report 2024
    26. Efficacy and safety of baricitinib in patients with alopecia areata: evidence to date Drugs in context · 2023
    27. 42736 Safety Assessments in the Multinational Phase 3 THRIVE-AA1 Trial with CTP-543 (Deuruxolitinib) in Adult Patients with Moderate to Severe Alopecia Areata Journal of the American Academy of Dermatology · 2023
    28. Spotlight in Plastic Surgery: October 2022 Plastic and Reconstructive Surgery · 2022
    29. P64 Efficacy of baricitinib in patients with different degrees of severe alopecia areata: 52-week results from BRAVE-AA1 and BRAVE-AA2 British Journal of Dermatology · 2023
    30. 32237 Clinician and patient evaluation of improvement for eyebrow and eyelashes hair loss during baricitinib phase 3 trials BRAVE-AA1 and BRAVE-AA2 Journal of The American Academy of Dermatology · 2022