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The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Dutasteride is becoming a popular hair loss treatment, proving more effective than finasteride with similar side effects.

Topical finasteride can effectively treat male pattern baldness with fewer side effects than oral use.

Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Finasteride reduces hair growth in women with hirsutism and works better with electrolysis.

RF-mesotherapy with dutasteride may be a promising alternative treatment for hair loss.

Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.

A reliable model for screening type II 5α-reductase inhibitors was created and validated.

Finasteride and dutasteride may cause metabolic issues like liver disease and diabetes.

Minoxidil is processed in the body by an enzyme found in the liver and platelets.

Dutasteride and finasteride affect different cell types differently.

Suppressing certain hormones might help prevent prostate cancer.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

Saw palmetto extract may help with hair loss and acne but needs more research on safety and long-term effects.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Cyclosporine-A can cause excessive hair growth, which usually stops after discontinuing the drug.

Hair loss from genetics and hormones can be treated with drugs or surgery.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

A plant mixture extract helped grow hair by boosting cell growth and growth factors while blocking a hair loss-related enzyme.

Taking Saw palmetto and Pygeum africana can change the levels of certain steroids in urine, which could cause confusion in doping tests.

Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.

Oral dutasteride works better for hair loss, but has more sexual side effects; intralesional dutasteride is a possible alternative.

Nanostructured delivery systems could potentially improve hair loss treatment by targeting drugs to hair follicles, reducing side effects and dosage, but the best size, charge, and materials for these systems need further investigation.

Urologists should monitor mental health in patients taking finasteride due to potential links to suicidal thoughts, adjusting dosage or stopping use if necessary. More research is needed to confirm if finasteride causes these thoughts.

Male pattern baldness is often genetic and linked to a hormone, with treatments like finasteride and minoxidil being effective for some men.

Phyto-vesicles of β-sitosterol may effectively treat hair loss.