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GlossaryInsulin-like Growth Factor

protein promoting cell growth and development, similar to insulin

Insulin-like Growth Factor (IGF) refers to a group of proteins with a structure similar to insulin that play a crucial role in growth and development, particularly during childhood. IGF is involved in cell growth, differentiation, and survival, and it is primarily produced in the liver in response to growth hormone stimulation. It has significant implications in various biological processes, including muscle growth, bone development, and even hair follicle health.

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Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

research Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

10 citations, August 2018 in “Dermatologic Surgery”

Laser treatment improves hair density and increases growth factors in androgenetic alopecia.

research Vertex Balding, Plasma Insulin-Like Growth Factor 1, and Insulin-Like Growth Factor Binding Protein 3

26 citations, June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3, suggesting these factors might be important in male pattern baldness.

research Vertex Balding, Plasma Insulin-Like Growth Factor 1, and Insulin-Like Growth Factor Binding Protein 3

3 citations, June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3 levels, suggesting these factors might influence male pattern baldness.

Both Low Circulating Insulin-Like Growth Factor-1 and High-Density Lipoprotein Cholesterol Are Associated with Hair Loss in Middle-Aged Women

research Both Low Circulating Insulin-Like Growth Factor-1 and High-Density Lipoprotein Cholesterol Are Associated with Hair Loss in Middle-Aged Women

6 citations, March 2016 in “British Journal of Dermatology”

Low IGF-1 and high HDL cholesterol levels are linked to more hair loss in middle-aged women.

research Role of Insulin-Like Growth Factor-1 Receptor in Female Androgenetic Alopecia

January 2020 in “Menoufia Medical Journal”

IGF-1R may play a role in female hair loss and could be a treatment target.

research Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells

8 citations, October 2020 in “International Journal of Molecular Sciences”

Nonanal from fruits and vegetables promotes hair growth by increasing growth factors.

research Cashmere Growth Control in Liaoning Cashmere Goat by Ovarian Carcinoma Immunoreactive Antigen-Like Protein 2 and Decorin Genes

7 citations, March 2018 in “Asian-Australasian journal of animal sciences”

OCIAD2 and DCN genes affect hair growth in goats by having opposite effects on a growth signaling pathway and inhibiting each other.

research Dermal Fibroblasts Enhance Growth Factors Production by Androgens and Modulate Keratinocyte Proliferation and Differentiation

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Androgens increase growth factors in skin cells, which may lead to acne.

research Human Umbilical Cord Blood Mesenchymal Stem Cells Engineered to Overexpress Growth Factors Accelerate Outcomes in Hair Growth

21 citations, January 2018 in “The Korean Journal of Physiology and Pharmacology”

Modified stem cells from umbilical cord blood can make hair grow faster.

Kojyl Cinnamate Ester Derivatives Increase Adiponectin Expression and Stimulate Adiponectin-Induced Hair Growth Factors in Human Dermal Papilla Cells

research Kojyl Cinnamate Ester Derivatives Increase Adiponectin Expression and Stimulate Adiponectin-Induced Hair Growth Factors in Human Dermal Papilla Cells

9 citations, April 2019 in “International Journal of Molecular Sciences”

Kojyl cinnamate ester derivatives can promote hair growth by increasing adiponectin production in fat tissues.

research Growth Factors in Hair Organ Development and the Hair Growth Cycle

90 citations, October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

research The Hair Growth Promoting Effect of Ascorbic Acid 2-Phosphate, a Long-Acting Vitamin C Derivative

33 citations, January 2006 in “Journal of Dermatological Science”

A long-acting Vitamin C derivative helps hair grow by stimulating cells and increasing growth factors.

research Action Mechanism of Chamaecyparis Obtusa Oil on Hair Growth

9 citations, December 2013 in “Toxicological Research”

Chamaecyparis obtusa oil may help hair grow similarly to minoxidil by affecting certain growth markers and cell factors.

research Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism of Action

June 2023 in “Current Issues in Molecular Biology”

DN106212, an extract from a plant, is better at promoting hair growth than other tested substances by affecting hair growth factors and follicle development.

research Hair Growth Is Promoted by BeauTop via Expression of EGF and FGF-7

7 citations, April 2018 in “Molecular Medicine Reports”

BeauTop helps hair grow by increasing certain growth factors.

research Pilosebaceous Physiology in Relation to Hirsutism and Acne

75 citations, May 1986 in “Clinics in endocrinology and metabolism”

Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.

research Neuroendocrinology of Epithelial Hair Follicle Stem Cells

42 citations, March 2008 in “Molecular and Cellular Endocrinology”

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

research Identification of Genes and Proteins Associated with Anagen Wool Growth

10 citations, September 2016 in “Animal genetics”

Researchers identified key genes and proteins linked to wool growth in sheep.

research Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice

28 citations, September 2019 in “International Journal of Nanomedicine”

Minoxidil nanoparticles can potentially be a more effective treatment for hair growth than current treatments.

research The Role of Mimicking Growth Factors to Control Anagen Phase: Evaluation In Vitro and In Vivo

February 2010 in “Journal of The American Academy of Dermatology”

Mimicking growth factors in a topical solution can prolong hair growth phase and reduce hair loss without side effects.

research The Hair Growth Promoting Effect of Sophora Flavescens Extract and Its Molecular Regulation

75 citations, October 2002 in “Journal of Dermatological Science”

Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.

research Role of Insulin Resistance and Diet in Acne

39 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

28 citations, October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

research Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

20 citations, January 2019 in “Journal of dermatological science”

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

research Activation of Hair Cell Growth Factors by Linoleic Acid in Malva Verticillata Seed

17 citations, April 2021 in “Molecules/Molecules online/Molecules annual”

Linoleic acid from Malva verticillata seeds may help treat hair loss by promoting hair cell growth and blocking baldness signals.

Pinus Thunbergii Bark Extract Rich in Flavonoids Promotes Hair Growth in Dorsal Skin by Regulating Inflammatory Cytokines and Increasing Growth Factors in Mice

research Pinus Thunbergii Bark Extract Rich in Flavonoids Promotes Hair Growth in Dorsal Skin by Regulating Inflammatory Cytokines and Increasing Growth Factors in Mice

5 citations, January 2022 in “Molecular Medicine Reports”

Pine bark extract helps mice grow hair by reducing inflammation and boosting growth factors.

research M2 Macrophages Promote Wound-Induced Hair Neogenesis Through the Production of Growth Factors

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

M2 macrophages help hair regrowth in wounds by making growth factors.

research Effects of Lycopersicon Esculentum Extract on Hair Growth and Alopecia Prevention

January 2014 in “PubMed”

Tomato extract can promote hair growth and prevent hair loss without irritating the skin.

Antioxidant Efficacy and Effects on Expression of Growth Factors in Human Hair Follicle Dermal Papilla Cells of Rosa Multiflora Root Extracts

research Antioxidant Efficacy and Effects on Expression of Growth Factors in Human Hair Follicle Dermal Papilla Cells of Rosa Multiflora Root Extracts

6 citations, June 2017 in “Asian journal of beauty & cosmetology”

Rosa multiflora root extracts may help promote hair growth and have anti-aging benefits.

Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

research Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

11 citations, July 2015 in “Gene”

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.