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    Glossary Insulin-like Growth Factor

    protein promoting cell growth and development, similar to insulin

    Insulin-like Growth Factor (IGF) refers to a group of proteins with a structure similar to insulin that play a crucial role in growth and development, particularly during childhood. IGF is involved in cell growth, differentiation, and survival, and it is primarily produced in the liver in response to growth hormone stimulation. It has significant implications in various biological processes, including muscle growth, bone development, and even hair follicle health.

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    1. Insulin-like growth factor 1 and hair growth Dermatology Online Journal · 1999 · 98 citations
    2. The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia Journal of The American Academy of Dermatology · 2003 · 49 citations
    3. Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil). Endocrinology · 1999 · 43 citations
    4. Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells PLoS ONE · 2011 · 39 citations
    5. Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-like Growth Factor 1 1999 · 33 citations
    6. Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae Growth Hormone & IGF Research · 2024 · 32 citations
    7. Insulin-like growth factor-1: roles in androgenetic alopecia Experimental Dermatology · 2014 · 27 citations
    8. Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3 Journal of The American Academy of Dermatology · 2000 · 26 citations
    9. Cow placenta extract promotes murine hair growth through enhancing the insulin - like growth factor-1 2011 · 22 citations
    10. Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women British Journal of Dermatology · 2016 · 6 citations
    11. Topical tacrolimus suppresses the expression of vascular endothelial growth factor and insulin-like growth factor-1 in late anagen Clinical and Experimental Dermatology · 2009 · 6 citations
    12. Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model Asian-australasian Journal of Animal Sciences · 2012 · 4 citations
    13. Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3 Journal of The American Academy of Dermatology · 2000 · 3 citations
    14. Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential Current Issues in Molecular Biology · 2025
    15. Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus Medical records-international medical journal · 2023
    16. Erythropoietin induces insulin-like growth factor-1 from three-dimensional culture of human dermal papilla cells Journal of Dermatological Science · 2012
    17. Role of insulin-like growth factor-1 receptor in female androgenetic alopecia Menoufia Medical Journal · 2020
    18. Role of insulin, insulin‐like growth factor‐1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris Experimental dermatology · 2009 · 200 citations
    19. Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I Disease Markers · 2016 · 29 citations
    20. Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice The Journal of Nutritional Biochemistry · 2011 · 29 citations
    21. Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes Annals of Dermatology · 2019 · 8 citations
    22. The Association Between Low (Or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case- Control Study in Basrah City of Iraq Zenodo (CERN European Organization for Nuclear Research) · 2026
    23. The Association Between Low (Or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case- Control Study in Basrah City of Iraq Zenodo (CERN European Organization for Nuclear Research) · 2026
    24. The Association between Low (or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case-Control Study in Basrah, Iraq European Journal of Medical and Health Research · 2026
    25. Self-assembling peptide inspired by insulin and type 1 insulin-like growth factor for the treatment of androgenetic alopecia Bioactive Materials · 2025
    26. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995 · 173 citations
    27. Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice Oncogene · 1997 · 147 citations
    28. Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet British Journal of Dermatology · 2016 · 93 citations
    29. Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles<i>in vitro</i> British Journal of Dermatology · 2014 · 60 citations
    30. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans Growth hormone & IGF research · 2008 · 39 citations