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    Glossary Insulin-like Growth Factor

    protein promoting cell growth and development, similar to insulin

    Insulin-like Growth Factor (IGF) refers to a group of proteins with a structure similar to insulin that play a crucial role in growth and development, particularly during childhood. IGF is involved in cell growth, differentiation, and survival, and it is primarily produced in the liver in response to growth hormone stimulation. It has significant implications in various biological processes, including muscle growth, bone development, and even hair follicle health.

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    1. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995 · 173 citations
    2. Insulin-like growth factor 1 and hair growth Dermatology Online Journal · 1999 · 98 citations
    3. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans Growth hormone & IGF research · 2008 · 39 citations
    4. Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae Growth Hormone & IGF Research · 2024 · 32 citations
    5. Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I Disease Markers · 2016 · 29 citations
    6. Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice The Journal of Nutritional Biochemistry · 2011 · 29 citations
    7. The localisation and characterisation of insulin-like growth factor-I receptors and the investigation of melatonin receptors on the hair follicles of seasonal and non-seasonal fibre-producing goats 1996 · 26 citations
    8. Promotion of Insulin-Like Growth Factor-I Production by Sensory Neuron Stimulation; Molecular Mechanism(s) and Therapeutic Implications Current medicinal chemistry · 2008 · 23 citations
    9. Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells Clinical and Experimental Dermatology · 2017 · 22 citations
    10. Cow placenta extract promotes murine hair growth through enhancing the insulin - like growth factor-1 2011 · 22 citations
    11. Induction of insulin‐like growth factor‐I by cepharanthine from dermal papilla cells: A novel potential pathway for hair growth stimulation The Journal of Dermatology · 2013 · 13 citations
    12. Expression of transforming growth factor-beta (TGF-beta 1) and insulin-like growth factor II (IGF-II) messenger RNA in the developing subcutaneous tissue (SQ) of the fetal pig. PubMed · 1992 · 11 citations
    13. Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model Asian-australasian Journal of Animal Sciences · 2012 · 4 citations
    14. Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus Medical records-international medical journal · 2023
    15. Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1 Journal of cellular physiology · 1996 · 37 citations
    16. Association of insulin-like growth factor 2 Apa1 A820G gene (rs680) polymorphism with polycystic ovarian syndrome International journal of reproduction, contraception, obstetrics and gynecology · 2016
    17. Study on Expression of Insulin-like Growth Factor-binding Protein-3and -5(IGFBP-3 and IGFBP-5)in the Skin of Inner Mongolia Cashmere Goat China Animal Husbandry & Veterinary Medicine · 2013
    18. The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia Journal of The American Academy of Dermatology · 2003 · 49 citations
    19. Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells PLoS ONE · 2011 · 39 citations
    20. Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-like Growth Factor 1 1999 · 33 citations
    21. Insulin-like growth factor-1: roles in androgenetic alopecia Experimental Dermatology · 2014 · 27 citations
    22. Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women British Journal of Dermatology · 2016 · 6 citations
    23. The Association between Low (or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case-Control Study in Basrah, Iraq European Journal of Medical and Health Research · 2026
    24. Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential Current Issues in Molecular Biology · 2025
    25. Self-assembling peptide inspired by insulin and type 1 insulin-like growth factor for the treatment of androgenetic alopecia Bioactive Materials · 2025
    26. Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil). Endocrinology · 1999 · 43 citations
    27. Formulation and Application of a Human Insulin-Like Growth Factor 1-Loaded Transfersomal System to Enhance Skin Wound Healing in Diabetic Rat Models International Journal of Nanomedicine · 2026
    28. Medications affecting the insulin-like growth factor 1/growth hormone axis, including teprotumumab, somatostatin analogs, and anti-calcitonin gene-related peptide monoclonal antibodies, are associated with elevated reporting odds of alopecia in women: A pharmacovigilance study Journal of The American Academy of Dermatology · 2023
    29. Role of insulin, insulin‐like growth factor‐1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris Experimental dermatology · 2009 · 200 citations
    30. Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3 Journal of The American Academy of Dermatology · 2000 · 26 citations