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GlossaryInsulin-like Growth Factor Binding Proteins

regulate insulin-like growth factors' activity and availability

Insulin-like Growth Factor Binding Proteins (IGFBPs) are a group of proteins that bind to insulin-like growth factors (IGFs), which are hormones involved in growth and development. By binding to IGFs, IGFBPs regulate their activity, availability, and interaction with IGF receptors, thereby playing a crucial role in cell growth, differentiation, and metabolism.

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research Regulation of Human Dermal Papilla Cell Production of Insulin-Like Growth Factor Binding Protein-3 by Retinoic Acid, Glucocorticoids, and Insulin-Like Growth Factor-1

37 citations, June 1996 in “Journal of cellular physiology”

Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.

research Vertex Balding, Plasma Insulin-Like Growth Factor 1, and Insulin-Like Growth Factor Binding Protein 3

26 citations, June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3, suggesting these factors might be important in male pattern baldness.

research Vertex Balding, Plasma Insulin-Like Growth Factor 1, and Insulin-Like Growth Factor Binding Protein 3

3 citations, June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3 levels, suggesting these factors might influence male pattern baldness.

research Study on Expression of Insulin-like Growth Factor-binding Protein-3 and -5 (IGFBP-3 and IGFBP-5) in the Skin of Inner Mongolia Cashmere Goat

January 2013 in “China Animal Husbandry & Veterinary Medicine”

IGFBP-5 likely plays a key role in goat hair growth.

research Insulin-Like Growth Factor-1: Roles in Androgenetic Alopecia

27 citations, March 2014 in “Experimental Dermatology”

IGF-1 affects hair loss and could be a potential treatment.

Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

research Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

20 citations, January 2019 in “Journal of dermatological science”

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

research Human Umbilical Cord Blood Mesenchymal Stem Cells Engineered to Overexpress Growth Factors Accelerate Outcomes in Hair Growth

21 citations, January 2018 in “The Korean Journal of Physiology and Pharmacology”

Modified stem cells from umbilical cord blood can make hair grow faster.

research Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD71 Positive Keratinocyte Cells

17 citations, February 2015 in “International Journal of Molecular Sciences”

A special mix from certain skin cells can help hair grow by making hair root cells grow faster and activating growth signals.

research Neuroendocrinology of Epithelial Hair Follicle Stem Cells

42 citations, March 2008 in “Molecular and Cellular Endocrinology”

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

research Skin Deep and Deeper: Multiple Pathways in Basal Cell Carcinogenesis

5 citations, September 2010 in “Cancer Prevention Research”

The research suggests new treatments for skin cancer could target specific cell growth pathways.

Prevalence of Polycystic Ovaries in Women with Self-Reported Symptoms of Oligomenorrhoea and/or Hirsutism: Northern Finland Birth Cohort 1966 Study

research Prevalence of Polycystic Ovaries in Women with Self-Reported Symptoms of Oligomenorrhoea and/or Hirsutism: Northern Finland Birth Cohort 1966 Study

77 citations, March 2004 in “Human Reproduction”

Women with irregular periods and/or excessive body hair are more likely to have polycystic ovaries, and this condition is linked to higher health risks.

research The Molecular Mechanism Underlying the Proliferating and Preconditioning Effect of Vitamin C on Adipose-Derived Stem Cells

42 citations, February 2014 in “Stem Cells and Development”

Vitamin C helps adipose-derived stem cells grow and may support hair growth.

Conditioned Media Obtained from Human Outer Root Sheath Follicular Keratinocyte Culture Activates Signalling Pathways That Contribute to Maintenance of Hair-Inducing Capacity and Increases Trichogenicity of Cultured Dermal Cells

research Conditioned Media Obtained from Human Outer Root Sheath Follicular Keratinocyte Culture Activates Signalling Pathways That Contribute to Maintenance of Hair-Inducing Capacity and Increases Trichogenicity of Cultured Dermal Cells

6 citations, July 2012 in “Experimental Dermatology”

The substance from human hair root cells can help maintain hair growth and make skin cells more capable of growing hair.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations, April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors to Improve Skin Regeneration

research Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors to Improve Skin Regeneration

5 citations, September 2019 in “ACS Applied Bio Materials”

The hydrogel with bioactive factors improves skin healing and regeneration.

research Distinct Tooth Regeneration Systems Deploy a Conserved Battery of Genes

September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Different fish use the same genes to regrow teeth.

research Growth Factors in Hair Organ Development and the Hair Growth Cycle

90 citations, October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

research Association of Insulin-Like Growth Factor 2 Apa1 A820G Gene (rs680) Polymorphism with Polycystic Ovarian Syndrome

January 2016 in “International journal of reproduction, contraception, obstetrics and gynecology”

A certain gene variation is linked to a higher risk of polycystic ovarian syndrome in South Indian women.

research Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-Like Growth Factor 1

33 citations, February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

IGF-1 increases whisker growth in transgenic mice.

Both Low Circulating Insulin-Like Growth Factor-1 and High-Density Lipoprotein Cholesterol Are Associated with Hair Loss in Middle-Aged Women

research Both Low Circulating Insulin-Like Growth Factor-1 and High-Density Lipoprotein Cholesterol Are Associated with Hair Loss in Middle-Aged Women

6 citations, March 2016 in “British Journal of Dermatology”

Low IGF-1 and high HDL cholesterol levels are linked to more hair loss in middle-aged women.

Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration

research Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration

19 citations, April 2015 in “Stem Cells”

Pro-IGF-II improves muscle repair in old mice.

research The Human Skin as a Hormone Target and an Endocrine Gland

146 citations, January 2004 in “Hormones”

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

research Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

11 citations, July 2015 in “Gene”

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

research Role of Insulin Resistance and Diet in Acne

39 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

research The Effects of Estrogens on Linear Bone Growth

11 citations, July 2001 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS”

Estrogens are key for bone growth spurts in both boys and girls and affect growth into adulthood.

research Gynecologic and Andrologic Dermatology and the Metabolic Syndrome

14 citations, September 2017 in “Clinics in Dermatology”

Skin diseases linked to insulin resistance should be managed to prevent diabetes and reduce heart disease risk.

research Hyperandrogenism and Polycystic Ovary Syndrome in Women with Type 1 Diabetes Mellitus

96 citations, February 2007 in “The Journal of Clinical Endocrinology & Metabolism”

Women with type 1 diabetes often have polycystic ovary syndrome and excess male hormones, which are frequently undiagnosed.

research Acne

2 citations, May 2011 in “Harper's Textbook of Pediatric Dermatology”

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

research Hair Growth Promoting Effect and Action Mechanism of Chrysanthemum Zawadskii Extract

January 2014

Chrysanthemum zawadskii extract may help treat hair loss by promoting hair growth and affecting growth factors.

research Low Anabolic Profile in Assessing a Patient’s Overall Hair Loss

1 citations, January 2015 in “Hair therapy & transplantation”

Some supplements and hormones can increase hair loss by raising DHT levels.