36 citations
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October 2014 in “Langmuir” This study concluded that bleach treatment partly transforms the hydrophobic top layer of human hair cuticles into a hydrophilic surface with clustered cysteic acid, visualized at the nano-scale using dynamic Chemical Force Microscopy.
2 citations
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February 2025 in “PLoS ONE” This study used TMT-based quantitative proteomics to analyze the development of secondary hair follicles in fetal sheep, revealing increased follicle density and key proteins involved, such as COL1A1 and THBS4, indicating their potential role in wool quality traits.
This review suggests that combining Platelet-Rich Plasma and microneedling may enhance hair restoration outcomes in patients with androgenetic alopecia compared to using either therapy alone.
409 citations
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May 1991 in “Genes & Development” This study observed that overexpression of TGF-alpha in transgenic mice led to thicker epidermis and stunted hair growth, particularly in regions with normally thick skin and low hair density.
109 citations
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December 1998 in “The Journal of Dermatology” This review discusses the hair follicle cycle's complex regulation and highlights the potential for targeting catagen control in future therapies without presenting new experimental data.
1 citations
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September 2025 in “Physiologia” This study found that systemic ovalbumin–aluminum sensitization followed by cutaneous challenge in mice induced thermal hyperalgesia, increased spinal cord gliosis, and sprouting of nociceptive fibers, along with elevated mast cell and nerve profile densities in the skin compared to controls.
February 2025 in “International Journal of Molecular Sciences” In this study, maternal melatonin implantation in pregnant rabbits reduced hair follicle cell apoptosis and increased hair follicle density in their neonatal offspring, suggesting a beneficial impact on hair follicle development mediated through specific molecular pathways.
December 2022 in “Nature Communications” This study found that a new "bead-jet" printing system for mesenchymal stem cells in Matrigel beads improved skeletal muscle regeneration and skin healing in a high-density, sparse pattern.
131 citations
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January 2018 in “Scientific Reports” In this study, mycorrhizal fungal inoculation was associated with increased root-hair growth and enhanced drought tolerance in trifoliate orange by modulating auxin synthesis and transport under water stress conditions.
12 citations
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January 2019 in “Regenerative Medicine” In this commentary, the authors discuss the challenges and proposals for responsibly translating regenerative therapies into clinical practice, emphasizing the need for patient education, quality control, and real-world evidence to validate these therapies and address ongoing misinformation in the field.
11 citations
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July 2021 in “Physiologia Plantarum” In this study, the gene SlPHL1 was identified as a transcription factor in tomatoes that enhances phosphate starvation responses by upregulating specific genes.
7 citations
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July 2022 in “Pharmaceutics” This study found that a dissolvable microneedle device delivering rapamycin and epigallocatechin gallate nanoparticles significantly enhanced hair regrowth in C57BL/6 mice within 7 days, demonstrating increased hair shaft growth and follicle density with minimal inflammation compared to untreated mice.
6 citations
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January 2024 in “Aesthetic Surgery Journal Open Forum” This study analyzed venture capital investments in plastic surgery from 2003 to 2023, finding $1.98 billion invested with a focus on general and facial cosmetic surgery, particularly minimally invasive devices, highlighting venture capital's significant role in shaping innovation in the sector.
3 citations
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February 2016 in “Nature Biotechnology” New drug shows promise for better hair growth in baldness treatment.
This study found that applying an ethanol extract of Prasiola japonica improved hair regrowth, length, and follicular density in testosterone-induced hair loss conditions in mice, while also promoting dermal papilla cell proliferation and reducing dihydrotestosterone production, though effects were less pronounced than those of minoxidil.
This study found that depleting fibroblasts in the skin does not affect the proliferative capacity of epidermal stem cells at various ages, suggesting robust compensatory mechanisms maintain skin functionality despite these cellular changes.
May 2026 in “Frontiers in Pharmacology” In this study, DOP treatment improved hair regrowth in androgenetic alopecia by altering local steroid metabolism and follicular morphology.
May 2026 in “Journal of Cutaneous and Aesthetic Surgery” In this study, researchers developed a novel bio-enhanced hair transplant technique that, among 10 patients, provided aesthetically pleasing outcomes with minimal downtime, linear increases in density over nine months, and uneventful donor area healing with no visible scarring.
This report details a refined hair transplantation method called direct no-shave follicular unit excision (DNS FUE), which avoids donor-site shaving and minimizes follicular trauma while yielding high patient satisfaction.
June 2025 in “Theranostics” This study found that exosomes derived from mesenchymal stem cells primed with rapamycin significantly enhanced hair regrowth, hair density, and hair follicle development in depilation-induced mice compared to controls, suggesting a potential therapeutic approach for hair loss.
This study tested a novel cryo-carboxy dispensing device for treating androgenetic alopecia in six volunteers and found an unexpectedly rapid and positive response, with significant hair regrowth observed by day 90, prompting early conclusion of the trial.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrated that prevascularized human skin constructs containing engineered hair follicles can successfully induce human hair growth when grafted onto mice by promoting blood supply to the grafted skin.
September 2017 in “Journal of Investigative Dermatology” Certain products and treatments can improve hair health and growth.
207 citations
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March 2012 in “Development” In this mouse study, researchers found that dermal Wnt signaling/β-catenin activity is essential for fibroblast proliferation and initiating hair follicle formation by interacting with epidermal Wnt ligands.
87 citations
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August 2017 in “Scientific Reports” This study found that PCL-based nanofiber scaffolds enhanced cell proliferation and extracellular matrix deposition, suggesting they show promise as a cell delivery system for improving skin wound healing.
43 citations
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July 2014 in “Experimental Dermatology” This review explores the relationship between hair follicles and wound healing, emphasizing the importance of translating scientific findings into practical therapies for chronic wounds, but it reports no new experimental results.
12 citations
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January 1978 The study observed that Friesian heifers experienced significant adaptation challenges to Kenya's equatorial conditions, taking around 18 months for their coat composition to resemble that of Dutch heifers in summer.
This article reviews surgical techniques for addressing scalp defects and highlights hair restoration as a cosmetic improvement strategy, but it reports no new clinical results.
May 2026 in “Signal Transduction and Targeted Therapy” This study found that rete ridge morphogenesis in mammalian skin is directed by a BMP-dependent developmental program, which is evolutionarily distinct from other known pathways controlling the development of hair follicles, sweat glands, and fingerprint ridges.
This study found that a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) significantly accelerated wound closure and improved healing in diabetic mice, also enhancing nerve and blood vessel formation compared to controls.