Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses recent advances in the treatment of alopecia areata, highlighting new potential therapies like JAK inhibitors and PRP, and reports no new clinical results.

Certain drugs and supplements may contribute to hair loss in the frontal hairline in older women.

This article discusses common causes of hair loss, specifically androgenetic alopecia and alopecia areata, but reports no new clinical findings.

This article discusses the biology of cosmetic aging and the chemical pathways involved, emphasizing research advancements that aid clinicians in rejuvenating skin and increasing scalp hair density, but it provides no new results.

Permanent hair loss after a stem cell transplant can be a sign of chronic immune system attack on the scalp.

This review discusses the discovery and potential therapeutic uses of proteasome inhibitors across various diseases, including cancer and autoimmune conditions, but does not present new clinical data.

Acitretin significantly reduced inflammatory attacks in a woman with Naevus Comedonicus Syndrome but caused side effects.

This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.

This case report describes a middle-aged man with alopecia universalis and ulcerative colitis, where hair regrowth occurred following treatment with azathioprine and mesalamine.

In this study, researchers found that alopecia areata patients show a significant reduction in suppressive regulatory T-cells and an increase in inflammatory T-cell populations, suggesting an immunological imbalance contributing to the disease.

In this study, stress levels measured through hair cortisol concentration gradually increased in the days before an acute myocardial infarction, peaking 15 days before the episode in male patients.

This review discusses testosterone replacement therapy, highlighting that most studies report no increased myocardial infarction risk when the therapy is properly administered with controlled hormone levels; it calls for careful consideration despite insurance coverage challenges.

This review discusses the interplay between hormonal and immune systems in hair follicles and reports no new results, highlighting the need for further research on their role in skin biology and alopecia areata.

This study suggests that diffuse alopecia areata initially involves an intense inflammatory attack during the anagen phase, progressing through different hair cycle stages with specific shedding patterns.

This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.

This study found that alopecia areata is linked to genetic factors, specifically HLA haplotypes on chromosome 6, and involves immune privilege collapse at hair follicles which is mediated by the JAK-STAT pathway and pro-inflammatory cytokines like IFN-γ.

This article proposes that alopecia areata may be caused by immune attacks on hair follicles after an immune privilege collapse, suggesting new therapeutic approaches targeting this immune response pattern.

In this study, researchers developed a mouse model of scarring alopecia and observed significant reductions in CD200R expression in affected skin, potentially linking this signaling pathway to immune attacks on hair follicles and suggesting new treatment targets for scarring hair loss.

This review provides a detailed overview of Hashimoto thyroiditis, discussing its epidemiology, risk factors, genetic and environmental contributors, clinical presentations, diagnostic methods, and treatment options, emphasizing the importance of personalized treatment plans due to varied causes and symptoms.

This review discusses various treatment options for alopecia areata, focusing on manipulating the immune response around hair follicles, but reports no new clinical results.

This study found that acute stress can cause rapid hair loss by triggering necrosis in hair follicle cells and initiating autoimmunity, revealing a mechanism where stress-induced nerve activity leads to tissue damage and immune system activation.

This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.

This case report discusses a successful treatment of Alopecia Areata with tofacitinib and includes a literature review on the condition's pathophysiology and the mechanism of JAK inhibitors, though it notes the high failure rate of available treatments and absence of FDA-approved options.

This preliminary study of Alopecia Areata identified limited expression of certain metabolic transporters and enzymes in hair follicle immune cells, providing early insight into their unique energy needs.

In this ex vivo and mouse model study, Tofacitinib-loaded nanoparticles demonstrated enhanced delivery of the drug into hair follicles and reduced inflammatory effects compared to conventional forms, indicating potential for safer, topical use in treating alopecia areata.

This study discusses the epithelial-immune microenvironment in chronic skin diseases, such as psoriasis and atopic dermatitis, and highlights current and future treatment strategies targeting inflammatory loops within these diseases.

This review discusses the various potential causes of hair loss in patients with inflammatory bowel disease, including telogen effluvium from disease flares, but provides no prevalence data; the authors outline a practical assessment and management approach.

A girl with Crohn's disease developed hair loss from her medication, which improved with treatment but later returned.

This study identified shared gene expression changes and immune cell infiltration patterns that may contribute to hair loss in alopecia areata and cutaneous lupus erythematosus, but also highlighted factors that might preserve hair in psoriasis patients.

This review examines targeting the JAK-STAT pathway in inflammatory skin diseases, highlighting existing JAK inhibitors and potential developments, but presents no new experimental or clinical results.