Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study reports two cases where acquired perforating dermatosis was localized to the scalp and coincided with acute diffuse alopecia, suggesting perifollicular inflammation may link the two conditions.

This study found a consistent association between atopic dermatitis and obesity, while links with other metabolic syndrome components like dyslipidemia and hypertension were inconsistent, indicating the need for targeted metabolic screening, particularly in moderate-to-severe cases.

This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.

This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.

This study found that placenta-derived mesenchymal stem cells overexpressing PRL-1 inhibited adipogenesis in orbital fibroblasts from Graves’ ophthalmopathy patients by modulating specific signaling pathways, suggesting a potential therapeutic strategy.

This study found that skin-resident Treg cells regulate hair follicle stem cell proliferation and differentiation through the Jag1-Notch signaling pathway, influencing hair regeneration.

This review discusses the role of exosomes in medical aesthetics, focusing on their mechanisms, production, and preservation, but reports no new clinical results and highlights barriers to their widespread application.

This study found that cardamonin can reduce inflammation in TNF-α-stimulated human periodontal ligament cells by suppressing specific cytokines and chemokines and inhibiting key inflammatory signaling pathways.

This review discusses the pharmacological activities and mechanisms of forsythiasides, highlighting their potential therapeutic value, but reports no new clinical results.

In this case report, a 24-year-old woman with Down syndrome effectively managed coexisting alopecia areata and hidradenitis suppurativa using upadacitinib, following partial success with previous treatments.

This review discusses the role of JAK inhibitors in treating atopic dermatitis, alopecia areata, and vitiligo, highlighting their effectiveness and safety considerations but stressing the need for further research on long-term safety and patient selection.

This study introduced a novel microneedle-based system for androgenetic alopecia treatment, which delivered Ginsenoside Compound K and S-nitrosoglutathione to enhance hair regeneration by improving the hair follicle microenvironment and promoting follicular cell proliferation.

This review discusses the formation of gintonin LPAs in ginseng during processing and reports no new clinical results; the authors suggest potential benefits against degenerative diseases through LPA receptors.

This review examines the potential of stem cells and their derived products, such as exosomes and conditioned media, in improving burn wound healing but presents no new clinical data.

This quiz article provides a series of dermatological diagnosis questions based on a Journal of Investigative Dermatology article and includes explanations but reports no original research findings.

This study reported that in mice with rapamycin-induced thymic atrophy, Angelica sinensis promoted thymic cortical regeneration and functional recovery by activating the Wnt/CTNNB1/Foxn1 signaling pathway and improving inflammatory microenvironment, suggesting its potential benefit against immune aging.

This study found that the new cocrystal formulation KET-PABA improved the antimycotic efficiency of ketoconazole and induced an anti-inflammatory response without causing skin sensitization in mice.

This study suggests that Gujian oral liquid may reduce osteoarthritis symptoms by regulating inflammation and catabolism through the TNF-α/NF-kappa B signaling pathway, as confirmed by both in vivo and in vitro experiments.

This animal study found that berberine may alleviate benign prostatic hyperplasia by reducing inflammation and oxidative stress through inhibition of the NF-κB signaling pathway.

This review discusses the potential of targeting Coenzyme A metabolism to restore metabolic balance, reduce chronic inflammation, and enhance immune function, particularly by modulating Vitamin B5 pathways involved in Th17-mediated inflammation and CD8-dependent anti-tumor immunity.

This study explored the molecular mechanisms by which Polygonum multiflorum may treat androgenic alopecia, suggesting it influences cell apoptosis and inflammation through specific pathways, with potential application value pending further testing.

This study reported that tryptanthrin, a compound found in indigo naturalis, effectively suppresses non-melanoma skin cancer in mice by reducing inflammation, inhibiting cell proliferation, and blocking specific signaling pathways associated with tumor growth.

This review highlights that the NLRP3 inflammasome is a promising therapeutic target for cerebral ischemia-reperfusion injury and discusses recent advancements in using natural plant products to modulate this pathway and reduce inflammation.

This study developed a smart PVA-TPE/HA-AMP/SF/ALG wound dressing that shows promise in infected wound healing by providing bacterial resistance, promoting cell proliferation, and modulating inflammation through various signaling pathways, potentially reducing scar formation.

This study investigated the effects of Taohong Siwu Decoction on deep vein thrombosis, identifying 56 potential targets and highlighting beta-sitosterol, quercetin, and kaempferol as key active components that may regulate inflammation through the PI3K/Akt pathway, potentially slowing disease progression.

This study developed a novel treatment method using carbon dots from Cinnamomum burmannii leaves, which improved hair regeneration and thickness in an AGA mouse model by promoting cell proliferation, angiogenesis, and reducing inflammation through multiple signaling pathways.

This review highlights the important role of the vitamin B complex in enhancing tissue repair, reducing inflammation, and improving surgical outcomes in plastic and reconstructive procedures by supporting cellular processes such as mitochondrial efficiency, neurotransmitter biosynthesis, and wound healing pathways.

This study highlights the role of immune dysregulation, microRNA modulation, and SIRT1 pathways in alopecia areata, suggesting antisense oligonucleotides targeting miR-485-3p as a promising therapeutic strategy for promoting hair regrowth and reducing inflammation in murine models.

This study explores the various properties of the flavonoid fisetin, highlighting its potential therapeutic applications due to its ability to modulate numerous biological pathways, suggesting benefits in conditions like inflammation, cancer, and neurodegenerative diseases.

This study suggests that inhibiting PKC, similar to rapamycin treatment, can extend lifespan and reduce neurological symptoms and inflammation in mice with mitochondrial dysfunction, potentially involving the mTORC2 pathway.