36 citations
,
August 2016 in “The Plant cell” This study found that downregulating PI3K in common bean severely impaired symbiosis with beneficial microorganisms, indicating an essential role for autophagy-related processes in these mutualistic interactions.
36 citations
,
April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that canine bulge-derived keratinocytes are highly proliferative and can reconstitute pilosebaceous structures, indicating their potential utility in studying human stem cell biology and hair disorders.
32 citations
,
February 2017 in “Human Reproduction” This study found that women with PCOS were more likely to have longer anogenital distances, indicating possible intrauterine origins linked to prenatal androgen exposure.
30 citations
,
February 1994 in “Journal of Cutaneous Pathology” This case study highlights that breast cancer may present as alopecia refractory to usual treatments, indicating the need for consideration of underlying malignancy in such cases.
28 citations
,
January 2007 in “Journal of dermatology” This case report describes instances of lipedematous scalp and lipedematous alopecia in white adults, indicating these rare conditions may be more widespread and frequent in this population than previously thought.
27 citations
,
February 2017 in “Clinical, Cosmetic and Investigational Dermatology” In this study, a topical formulation with compounds from the monoterpenoid family significantly improved hair growth indicators like anagen:telogen ratio, hair fall, and visual hair density in men and women with pattern hair loss.
27 citations
,
May 2002 in “The Journal of Clinical Endocrinology & Metabolism” This study found that brothers of women with PCOS exhibit elevated DHEAS levels, indicating a potential familial genetic trait, but did not show increased rates of premature balding.
27 citations
,
July 1997 in “PubMed” This study suggests that the harlequin ichthyosis mouse model closely resembles human type 2 harlequin ichthyosis, indicating its potential as a useful model for studying the human condition.
26 citations
,
March 2014 in “Rheumatology” This study confirms an association between TNF-α antagonist exposure and alopecia, indicating a class effect among the medications examined.
26 citations
,
May 2013 in “British Journal of Dermatology” This study provides evidence that a polygenic component contributes to the heritable risk for androgenetic alopecia, indicating the need for further research to identify the complex biological pathways involved.
26 citations
,
December 1979 in “Journal of Cutaneous Pathology” This study found that trichostasis spinulosa was present in some seborrheic keratoses, indicating they may partly originate from hair follicle cells.
25 citations
,
August 2014 in “Endocrinology” This study created a humanized mouse model of hereditary vitamin D-resistant rickets that lacks alopecia, indicating the mutant receptor's potential to explore the syndrome's characteristics beyond vitamin D binding.
22 citations
,
January 2019 in “Climacteric” This study reports that oophorectomy significantly reduces serum testosterone levels in postmenopausal women, indicating the postmenopausal ovary's continued production of testosterone.
22 citations
,
September 1982 in “Journal of ultrastructure research” This study reports new cellular features and complex interaction systems in fiber differentiation, indicating more intricate cellular organization than previously recognized, including features like mast cells and primary cilia.
19 citations
,
April 2021 in “Pain Medicine” This case report highlights the potential for Kratom misuse leading to addiction and significant health risks, indicating a need for more detailed human studies on its effects and management strategies.
16 citations
,
April 2025 in “Journal of the American Academy of Dermatology” In this study, an expert panel established a consensus guideline indicating that photobiomodulation is a safe and effective treatment for various conditions, including peripheral neuropathy and androgenic alopecia.
16 citations
,
December 2018 in “Skin pharmacology and physiology” This study found that in people with alopecia areata, oxidative stress indicators were higher and specific enzyme activities were lower compared to healthy controls, suggesting oxidative stress's significant role in disease pathogenesis.
14 citations
,
February 1991 in “FEBS Letters” This study found that introducing rat ornithine transcarbamylase gene into spf-ash mice improved liver and intestinal enzyme activity and normalized some metabolic indicators.
13 citations
,
January 2011 in “Journal of natural pharmaceuticals” This study suggests that extract from Musa paradisiaca unripe fruit may promote hair growth in mice, indicating potential as a hair growth treatment.
13 citations
,
January 1997 in “Biochemical Pharmacology” This study found that human liver dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfate conjugation of minoxidil, indicating another pathway contributing to its metabolism in humans.
12 citations
,
October 2013 in “British Journal of Dermatology” This meeting report provides an overview of recent evidence on vitiligo treatments, indicating a lack of standardized outcome measures and emphasizing the need for more consistent clinical trials.
12 citations
,
April 1960 in “The anatomical record” This study found that X-irradiation affects the differentiation of hair follicles in mice, indicating possible impacts on hair growth.
11 citations
,
September 2005 in “International Wound Journal” This case report documents the first known instance of heparin necrosis linked to tinazaparin, indicating that low-molecular-weight heparin may still cause serious side effects like conventional heparin.
9 citations
,
April 2025 in “Stem Cell Research & Therapy” This review suggests that MSC-derived conditioned media hold promise in dermatology, with studies indicating enhanced therapeutic effects when used alongside treatments like laser therapy and microneedling, leading to improved dermatological outcomes.
9 citations
,
May 2002 in “PubMed” This study demonstrated that mice lacking skin-specific RXRalpha expression developed hair follicle degeneration and alopecia, indicating the importance of RXRalpha/VDR heterodimers in maintaining hair follicle homeostasis.
8 citations
,
January 2011 in “Experimental and Therapeutic Medicine” This review summarizes the characteristics of the peri-malignant melanoma stroma, indicating its potential role in early dermal metastatic migration and increased metastasis risk.
8 citations
,
March 2010 in “Chinese medical journal/Chinese Medical Journal” This study found that antifungal therapy significantly reduced pustules in patients with refractory acne, indicating a potential role for Malassezia infection in such cases.
8 citations
,
September 2002 in “Genes to Cells” This study suggests that label-retaining cells in the hair follicle contribute to follicular renewal, indicating a specific role in the hair cycle by proliferating during the late telogen phase.
7 citations
,
July 2022 in “Pharmaceuticals” This study reports that pumpkin seed oil-loaded niosomes significantly decreased hair loss and increased hair growth indicators in vivo, suggesting potential as a natural anti-hair loss therapy.
7 citations
,
July 2021 in “The Journal of Dermatology” This study in Asian females found that higher use of moisturizers and sunscreen among FFA patients may reflect appearance concerns rather than indicating a direct link to the disease mechanism.