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In this review, researchers discussed recent advances in nanotechnology for topical skin applications, highlighting how nanocarriers enhance skin penetration and targeting in treatments for diseases like melanoma and psoriasis, while acknowledging that the penetration mechanisms and health impacts of nanoparticles remain not fully understood.

This review article explores the potential of various mesenchymal stem cell populations derived from oral tissues, such as DPSCs and hPCy-MSCs, in bone tissue engineering and regeneration, detailing their high plasticity and clinical applications in dental procedures.

This review examines various new approaches for treating dry eye disease, including biomaterials, regenerative therapy, and tissue engineering, and emphasizes the need for clinical efficacy studies to advance these therapies for human use.

This study found that coadministration of pimecrolimus may interfere with the therapeutic efficacy of mesenchymal stem cell therapy in atopic dermatitis.

This review discusses the interaction between mesenchymal stem cell secretomes and retinal cell secretomes, suggesting their potential in experimental therapies to protect and regenerate retinal tissue.

This study reviews the structural and functional aspects of cell-cell and cell-matrix junctions in sebocytes, emphasizing their roles in sebocyte differentiation and sebum secretion, and how these processes may change in pathological conditions, potentially providing insights for new skin disease therapies.

This study reviews various factors affecting mesenchymal stem cell transplantation efficacy, including platelet concentrate composition, donor characteristics, and environmental influences, and examines strategies for optimizing outcomes through preconditioning and combined therapies in regenerative medicine.

This review examines nanozymes as promising tools for cancer diagnosis and therapy due to their enzyme-mimicking catalytic properties and highlights their challenges, including biosafety and clinical translation, alongside potential improvements through biomimetic designs, particularly utilizing exosome-based strategies for targeted delivery to tumors.

This review highlights the mechanisms and therapeutic potential of mesenchymal stem cell-derived exosomes in regenerative medicine and discusses recent advances in their use for treating various ailments, without presenting new clinical findings.

This review discusses the potential of silk fibroin-based injectable hydrogels as next-generation biomaterials for regenerative medicine, exploring their therapeutic advantages, challenges, and future clinical applications.

This study suggests that Epimedium can serve as a complementary and alternative treatment for chronic bone and joint diseases, potentially laying the groundwork for its clinical application.

In this review, the authors systematically summarize recent advances in using hair follicle neural crest stem cells and their exosomes for repairing peripheral nerve injuries, focusing on mechanisms and applications derived from existing literature, although it does not include primary experimental data.

In this review, researchers detail how immunosenescence and chronic neuroinflammation contribute to Parkinson's disease progression, exploring potential therapeutic strategies targeting this axis, such as senolytic agents and immune rejuvenation, while highlighting associated challenges and future research needs.

This review discusses the increasing reports of rare cutaneous side effects from topical imiquimod, aiming to inform physicians and dermatologists about its potential adverse effects as its use expands.

This study found that activating Toll-like receptor 3 signaling in periodontal ligament stem cells may enhance their immunomodulatory properties, suggesting potential implications for future stem cell therapy applications.

This review discusses recent advancements in biomaterial scaffolds for wound healing, focusing on their roles and potential in skin regeneration, but it does not present new clinical results.

This review suggests that brassinosteroids may have similar biological activities in both plants and other organisms, prompting further exploration of steroid regulation mechanisms across different life forms.

This review explores the medicinal properties of Eclipta alba and its phytoconstituents and reports their potential for developing new drugs, but presents no new research results.

This study outlines new strategies for overcoming "cold" tumors, which are typically unresponsive to cancer immunotherapy, with approaches like dendritic cell-based treatments and local immune microenvironment modification, bolstered by both preclinical and clinical trial data.

This review discusses the use, mechanism, and side effects of topical immunomodulators in treating immune-mediated skin disorders and reports no new clinical results, urging further research on experimental agents.

Immunosuppressive therapy helps manage autoimmune diseases but carries risks like infection and potential for malignancy.

This article discusses how designing biomaterials to modulate immune responses has become a promising strategy for enhancing tissue repair and regeneration.

This study reported that intensive immunosuppression in multiple sclerosis patients significantly reduced relapse rates versus pre-treatment expectations, though some required ongoing treatment after tapering.

This review discusses the impact of immune-modifying therapies on COVID-19 vaccine responses, noting that a complete vaccine course can improve initially inadequate humoral responses among treated individuals compared to a single dose.

This study found that patients with alopecia areata receiving combined therapy showed a significant reduction in proinflammatory cytokines and circulating immune complexes, along with increased IL-10 levels and phagocytic activity, suggesting an immunomodulatory effect that reduces inflammation and restores immune balance.

This review examines various immunomodulatory therapies for cutaneous lymphoma and notes that they are most effective in the disease's early stages.

Leflunomide may reduce the risk of alopecia areata, while methotrexate, cyclosporine, and rituximab may increase it.

This study found that tumor immunotherapy, while effective against solid tumors, can disrupt the immune balance in hair follicles, causing follicular toxicity and alopecia, highlighting the need for targeted interventions to manage these adverse effects.

This study tested a hydrogel microneedle patch delivering T reg attractants in mice with alopecia, finding it boosted regulatory T cell numbers at the site, leading to hair regrowth without causing peripheral immunosuppression, suggesting a potential new approach for autoimmune skin disease treatment.

Regulatory T cells help prevent autoimmunity and have potential for treating autoimmune diseases.