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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

New nanofiber technology improves wound healing by supporting cell growth and delivering treatments directly to the wound.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Stem cell niches support, regulate, and coordinate stem cell functions.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Androgens can cause hair growth in some areas and hair loss on the scalp.

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

Peptide hydrogels heal burn wounds faster and better than standard dressings.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Platelet-rich plasma might help with hair growth and skin conditions, but more research is needed to prove its effectiveness and safety.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

The research identified various cell types in mouse and human teeth, which could help in developing dental regenerative treatments.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.