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    Glossary Immune response modifier

    substance that alters immune system reactions to threats

    An immune response modifier is a substance that can alter the way the immune system reacts to various threats, such as infections or diseases. These modifiers can either boost the immune response to help fight off pathogens or suppress it to reduce inflammation and autoimmunity. For example, in the context of alopecia, certain immune response modifiers might be used to prevent the immune system from attacking hair follicles, thereby reducing hair loss.

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    1. Montagna Symposium 2013—Light and Skin: How Light Sustains, Damages, Treats, Images and Modifies Skin Biology 2014 · 1 citations
    2. Skin wound healing in humans and mice: Challenges in translational research Journal of Dermatological Science · 2017 · 276 citations
    3. Study of<i>Demodex</i>mites: Challenges and Solutions Journal of the European Academy of Dermatology and Venereology · 2015 · 41 citations
    4. Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells By Hair Follicles and their Transport in Mice 2008 · 119 citations
    5. A case of widespread actinic granuloma with associated drug-induced lupus erythematosus Journal of The American Academy of Dermatology · 2016 · 1 citations
    6. Acquired immunogenicity of DNA after modification with malondialdehyde in patients with alopecia areata Scandinavian journal of clinical and laboratory investigation · 2014 · 10 citations
    7. 24 ARQ-234: a high affinity CD200-Fc fusion protein for the treatment of atopic dermatitis 2023
    8. Microbial allies in skin trauma recovery: from immune modulation to engineered probiotic therapeutics Burns & Trauma · 2025
    9. Ultrasound-activated piezoelectric hydrogel scaffold for synergistic immunomodulation and angiogenesis in accelerated wound healing Acta Biomaterialia · 2025
    10. 3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis Bioactive Materials · 2024 · 22 citations
    11. Cytokine Engineering Approaches for Regenerative Medicine Advanced Therapeutics · 2025 · 3 citations
    12. Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report Therapeutic Advances in Drug Safety · 2025 · 1 citations
    13. Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia PLOS ONE · 2012 · 22 citations
    14. The Impact of Immune-Modifying Treatments for Skin Diseases on the Immune Response to COVID-19 Vaccines: a Narrative Review Current Dermatology Reports · 2022 · 2 citations
    15. Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing Nature Materials · 2020 · 328 citations
    16. The Pathological Changes and Polymorphonuclear and Mast Cell Responses in the Skin of Specific Pathogen‐free Lambs Following Primary and Secondary Challenge with Orf Virus Veterinary Dermatology · 1990 · 18 citations
    17. Preferential Recognition of Hydroxyl Radical-Modified Superoxide Dismutase by Circulating Autoantibodies in Patients with Alopecia Areata Annals of Dermatology · 2014 · 12 citations
    18. Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata Scientific Reports · 2018 · 19 citations
    19. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002 · 114 citations
    20. Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides BMC Immunology · 2025
    21. Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells Journal of immunology research · 2019 · 47 citations
    22. The Human Innate Immune Protein Calprotectin Elicits a Multimetal Starvation Response in Pseudomonas aeruginosa Microbiology Spectrum · 2021 · 27 citations
    23. SOCS1 and SOCS3 as key checkpoint molecules in the immune responses associated to skin inflammation and malignant transformation Frontiers in Immunology · 2024 · 26 citations
    24. Environmental Modulation of JAK3-Mediated Immune Dysregulation in Alopecia Areata Scholarly Commons (Embry–Riddle Aeronautical University) · 2025
    25. Regulatory pathways implicated in male androgenetic alopecia pathogenesis British Journal of Dermatology · 2017
    26. COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine Mayo Clinic Proceedings · 2020 · 58 citations
    27. Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways British Journal of Dermatology · 2017 · 27 citations
    28. Alopecia Areata KARGER eBooks · 2008 · 24 citations
    29. Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus Scientific Reports · 2020 · 13 citations
    30. Molecular Genetics of Alopecias Current problems in dermatology · 2015 · 9 citations