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Testosterone treatment for older men can have short-term benefits, but long-term risks are unclear, requiring careful evaluation and monitoring.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.

New male hormonal contraceptives show promise but need more research on long-term effects and funding for larger trials.

Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.

Testosterone replacement is recommended for men with low testosterone levels and symptoms of hypogonadism.

Using anabolic-androgenic steroids can harm men's reproductive health and increase the risk of heart problems and death.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Blocking CRF1 receptors improved male hormone levels and reduced testicular tumor size in men with a specific adrenal condition.

New treatments for male hypogonadism are effective and should be personalized.

Long-term finasteride use doesn't change bone density or metabolism.

Hormone therapy for prostate cancer can increase heart risks, especially in men with heart conditions.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

Testosterone therapy can help improve mood, sexual function, and bone health in women with low androgen levels, but more research is needed to establish safe and effective guidelines.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.