Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review evaluates in vitro hair follicle models, techniques, and challenges without reporting new clinical results, emphasizing their future potential in hair transplantation.

This review discusses the current state of research on skin organoids, highlighting their potential for replicating complex skin structures and comparing recent studies on stem cell microenvironments.

This review discusses the challenges of traditional phytochemical delivery methods and highlights the potential of microneedles to improve intra/transdermal delivery, reporting no new clinical results.

This study reviews the etiology and treatment of skin cancer, focusing on nanotechnology's role in addressing drug resistance and evaluating nanoparticles' potential to improve treatment outcomes, including overcoming multidrug resistance.

This review highlights that while nanoparticle-loaded dissolving microneedles have considerable promise for enhancing transdermal drug delivery, progress is delayed by insufficient understanding of their in vivo behavior, which the authors emphasize as crucial for advancing clinical applications.

This review discusses the potential of stem cell-derived extracellular vesicles for improving diabetic wound healing and highlights their mechanisms, limitations, and challenges, but provides no new clinical findings.

This study found that soluble CD83 (sCD83) accelerated chronic and hard-to-heal wound healing and improved inflammatory and pro-resolving cytokine profiles, suggesting potential for therapeutic use.

In this review, the authors discuss the promising role of exosomes from various cell sources as potential cell-free therapies for diabetic foot ulcers, highlighting their therapeutic benefits in wound healing and the challenges faced in their clinical application.

This review discusses the potential of cathelicidins in treating skin conditions but highlights significant challenges, including unclear clinical efficacy, safety concerns, and bacterial resistance, that must be addressed for successful medical application.

This study observed that mice with a whole-body deficiency of Cystathionine-β-synthase developed severe hyperhomocysteinemia and related mild symptoms without increased mortality, indicating HHCy may not directly cause end organ damage.

This review highlights that current in vitro models often fail to replicate the physiological oxygen levels experienced by different skin cell types, which could affect redox states and functions, potentially accelerating skin aging.

This review discusses recent advancements in understanding how the sympathetic nervous system and norepinephrine regulate hair follicle growth, highlighting innovative studies that explore their effects on hair follicle stem cells.

This study reviews various factors affecting mesenchymal stem cell transplantation efficacy, including platelet concentrate composition, donor characteristics, and environmental influences, and examines strategies for optimizing outcomes through preconditioning and combined therapies in regenerative medicine.

This review explores the crucial role of regulatory T cells in skin wound healing, emphasizing their involvement in balancing immune responses and promoting regeneration. It also discusses Tregs' operations in fibrosis, keloidosis, and scarring, suggesting a potential avenue for novel treatments.

In this study, researchers found that miR-143-3p may play a novel role in cashmere growth by directly repressing the expression of Itga6 in secondary hair follicles of goats.

This study demonstrated that genetically engineered, ATP-responsive nanozymes effectively reduce cardiac fibrosis by targeting activated cardiac fibroblasts, resulting in decreased myofibroblast accumulation and improved cardiac function, suggesting that this approach has significant potential for therapeutic applications.

This review discusses the potential of microneedles in cancer diagnosis and treatment, highlighting advances and ongoing clinical trials, but reports no new results; it emphasizes the minimally invasive nature of this technology.

This review discusses various microneedle technologies for long-acting drug delivery, highlighting design considerations and challenges in bringing these minimally invasive devices to market, but it reports no new clinical results.

In this study, researchers found that Wnt4 overexpression increased the thickness of burn wounds by promoting epidermal cell migration and activating the canonical Wnt signaling pathway.

This review examines the mechanisms behind pathological scarring like hypertrophic scars and keloids, highlights the limitations of current treatments, and suggests that biomaterial-enabled delivery of anti-fibrotic statins, such as atorvastatin, may offer a promising therapeutic avenue for managing these scars.

This source reviews current understanding of fibroblast lineage differentiation and its role in wound healing, highlighting the potential to reprogram adult cells for scar-free repair by emulating fetal-like regenerative states.

This paper reviews advancements in 3D human skin models using bioprinting, organoid, and organ-on-a-chip technologies, noting improvements in physiological realism through vascularization and multi-omics data, but also highlighting challenges such as cost and lack of standardization that hinder clinical adoption.

This review explores current knowledge on fibroblast lineage specification and its impact on scar-free wound healing, noting that early fetal skin fibroblasts support regeneration, while later developmental shifts lead to fibrosis, highlighting potential strategies to reprogram adult fibroblasts for regenerative repair.

This review explores the potential of exosomes, which contain substances that may stimulate hair follicle activity, as a new therapeutic strategy for alopecia, and discusses their possible benefits and risks based on current knowledge of microRNAs and intracellular signaling in hair follicle morphogenesis.

This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.

This study reviews emerging techniques in acute burn wound therapy, noting innovations such as advanced imaging for better wound assessment and new closure strategies aimed at improving healing, graft survival, and scarring outcomes, while emphasizing the need for further research to validate these methods.

This review discusses the role of nanocarrier systems, such as nanoemulsions and liposomes, in delivering antioxidants into the skin to counteract oxidative stress, highlighting recent advancements in topical antioxidant therapy through nanotechnology.

This study reviewed various methods and techniques aimed at overcoming limitations in culturing human hair follicles, specifically focusing on restoring the inductivity of hair follicle cells for successful hair regeneration.

This review discusses the role of extracellular vesicles in psoriasis pathogenesis and their potential as therapeutic agents or drug delivery systems, but it reports no new clinical findings.

This review examines how skin organoids, derived from stem cells, are constructed to simulate skin functions and are pivotal in wound healing and regeneration, highlighting their promising roles in both research and therapeutic applications.