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Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

New genes and pathways are important for testosterone production and male sexual development.

Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.

Sabal and Urtica extract works as well as finasteride for treating BPH, with fewer side effects.

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.

Both drugs lower DHT levels, with GI198745 being more effective.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.

Edible seeds from the Cucurbitaceae family like pumpkin and watermelon seeds are nutritious and may have health benefits, but eating too much can cause side effects.

Certain drugs that block specific enzymes can help treat prostate diseases.

Finasteride might lower the risk of low-grade prostate cancer but not high-grade cancer, while alpha-blockers might reduce high-grade cancer risk.

Finasteride may cause floppy-iris syndrome during cataract surgery, so check patients' medical history.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.

Genetic defects in androgen production are linked to male developmental disorders and are improving treatment understanding.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

To diagnose Polycystic Ovarian Syndrome, two out of three signs—irregular periods, high male hormone levels, or cysts on the ovaries—are needed.

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

Heparan sulfate is important for hair growth, preventing new hair formation in mature skin, and controlling oil gland development.

The document concludes that correct diagnosis and management of PCOS are important, and more research is needed on its risks and treatments.

The main cause of excessive hair growth in Turkish women is Polycystic ovary syndrome, but in about one fifth of cases, the reason for high male hormone levels is unknown.