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    Glossary Skin Equivalents

    lab-grown models mimicking human skin for research and testing

    Skin equivalents are lab-grown models of human skin created using a combination of cells and biomaterials. These constructs mimic the structure and function of natural skin, making them valuable for research, drug testing, and studying skin diseases without the need for human or animal subjects.

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    Research 30 of 1000+

    1. The importance of the neuro‐immuno‐cutaneous system on human skin equivalent design Cell Proliferation · 2019 · 73 citations
    2. Development of a novel in vitro strategy to understand the impact of shaving on skin health: combining tape strip exfoliation and human skin equivalent technology Frontiers in Medicine · 2023
    3. Restructuring skin equivalents with human hair follicle orscs and fibroblasts Journal of Plastic Reconstructive & Aesthetic Surgery · 2007
    4. Skin equivalent containing collagen-human hair keratin matrice for formation of neodermis Jiepouxue zazhi · 2003
    5. An improved and rapid method to construct skin equivalents from human hair follicles and fibroblasts Experimental dermatology · 2001 · 48 citations
    6. 3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration Wound Repair and Regeneration · 2025 · 3 citations
    7. Endogenous human skin equivalent promotes in vitro morphogenesis of follicle-like structures Biomaterials · 2016 · 36 citations
    8. Characterization of a new tissue-engineered human skin equivalent with hair In Vitro Cellular & Developmental Biology - Animal · 1999 · 221 citations
    9. Self Organized Skin Equivalent by Epithelial and Fibroblast Cells on Polycaprolactone Electrospun Mat with Porous Fibers Advances in tissue engineering & regenerative medicine · 2017 · 4 citations
    10. Enhanced Differentiation Potential of Pigmented Human Epidermal Equivalents 2026
    11. Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging Ageing Research Reviews · 2026
    12. De novo formation and ultra-structural characterization of a fiber-producing human hair follicle equivalent in vitro Journal of biotechnology · 2011 · 44 citations
    13. In-vitro permeation of drugs into porcine hair follicles: is it quantitatively equivalent to permeation into human hair follicles? Journal of Pharmacy and Pharmacology · 2008 · 19 citations
    14. Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction International Journal of Molecular Sciences · 2021 · 54 citations
    15. Tissue-scale tensional homeostasis in skin regulates structure and physiological function Communications Biology · 2020 · 47 citations
    16. Recent advances in understanding the role of the skin microbiome in the treatment of atopic dermatitis Experimental Dermatology · 2023 · 18 citations
    17. 918 Tissue engineered human hair follicles from genetically, environmentally and extrinsically reprogrammed dermal papilla cells 2017
    18. Plucked Human Hair Shafts and Biomolecular Medical Research 2013 · 8 citations
    19. In Vitro Skin Models for Pigmentary Disorders: From Reconstructed Tissues to Skin-on-a-Chip Platforms Regenerative Biomaterials · 2026
    20. Human relevant platforms for cutaneous wound healing research: current landscape, translational gaps, and emerging frontiers Frontiers in Bioengineering and Biotechnology · 2026
    21. Skin Tissue-Engineering Constructs and Stem Cells Application for the Skin Equivalents Creation (Review) Sovremennye tehnologii v medicine · 2017 · 11 citations
    22. 560 Isolation of an “early” transit amplifying keratinocyte population in interfollicular human epidermis: a role for CD271 receptor Journal of Investigative Dermatology · 2022
    23. 501 Next-generation in vitro testing: microfluidic models for aging, wound healing, and oral tissue analysis in safety, efficacy, and permeation studies Journal of Investigative Dermatology · 2024
    24. Optimization of hair follicle spheroids for hair-on-a-chip Biomaterials Science · 2024
    25. 858 IPSC derived keratinocyte differentiation from reprogrammed blood cells Journal of Investigative Dermatology · 2017
    26. 859 Building a functional niche for hair follicle stem cells Journal of Investigative Dermatology · 2017
    27. 331 Characterisation of interfollicular stem cells and early TA cells during the transition from infant to child skin Journal of Investigative Dermatology · 2021
    28. Engineering a 3D wounded skin equivalent to study early inflammatory and regenerative responses in vitro Frontiers in Bioengineering and Biotechnology · 2025 · 1 citations
    29. Reconstitution of human skin in vitro using readily available sources: Novel studies of tumour promotion Toxicology in Vitro · 1994
    30. The human hair follicle has established a fully functional peripheral equivalent of the hypothamalic‐pituitary‐adrenal‐axis (HPA) Experimental Dermatology · 2005 · 9 citations