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Arsenic exposure from contaminated water severely damages the skin, causing hair loss, pigmentation changes, irritation, and can lead to skin cancer.

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

A woman with a unique syndrome similar to TRPS has a genetic change near the TRPS1 gene, affecting its regulation.

Special gels help heal diabetic foot sores and reduce the risk of amputation or death.

Efficient delivery systems are needed for the clinical use of CRISPR-Cas9 gene editing.

Hidradenitis Suppurativa has genetic links, with certain gene mutations more common in patients and a third of cases having a family history.

Keratin 79 marks a new group of cells that are key for creating and repairing the hair follicle's structure.

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

The PP2A-B55α protein is essential for brain and skin development in embryos.

Inhibiting class I HDACs helps maintain hair growth ability in skin cells.

Ptprq has multiple forms that change during inner ear development.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Hydrogen peroxide can cause scars by changing healing processes and increasing certain protein levels.

Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.

There are two types of stem cells in rodent hair follicles, each with different keratin proteins.

A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Hormones control reproduction and are crucial for body balance.

The protein STAT3 slows down cell growth by blocking the FST gene, which affects hair development in sheep.

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

Thymosin β4 and VEGF are important for blood vessel formation in many organs.

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

IL-3 worsens lupus nephritis and blocking it improves kidney health.

COVID-19 may harm male fertility and damage the reproductive system.

Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.

Disrupting the Flcn gene in mice causes early kidney cysts and tumors, which can be treated with rapamycin.

Mechanical force is important for the first contact between skin cells and hair growth in mini-organs.

New patents show progress in developing drugs targeting the Wnt pathway for diseases like cancer and hair loss.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Organoids created from stem cells are used to model diseases, test drugs, and develop personalized and regenerative medicine.