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Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

The genetic variant studied does not affect PCOS symptoms in Kashmiri women.

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Women with a certain type of tumor had higher levels of pregnancy hormone and male hormones, which decreased after treatment.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Researchers created a mouse model of a type of rickets that does not cause hair loss.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

Two siblings with a genetic mutation had a form of rickets that doesn't respond to vitamin D.

The IRS-2 Asp/Asp genotype may increase the risk of PCOS in Chinese women, especially if they are not obese.

Longer CAG repeat lengths in the androgen receptor gene are linked to higher testosterone levels in women with PCOS.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

Dutasteride and finasteride affect different cell types differently.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

We need better ways to test and understand SARMs to make safer and more effective treatments.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Certain genetic variants in the androgen receptor are linked to higher PSA levels, potentially affecting prostate cancer screening outcomes.

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

Hairless protein can block vitamin D activation in skin cells.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.