8 citations
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June 2019 in “Journal of Ginseng Research” This study found that a gintonin-enriched fraction from ginseng promoted hair growth in mice by stimulating dermal papilla cell proliferation and increasing hair follicles and weight.
7 citations
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December 2016 in “Journal of The Taiwan Institute of Chemical Engineers” This study found that porcine platelet-rich plasma can be a commercially viable replacement for fetal bovine serum with similar effectiveness in promoting human hair follicle cell growth.
6 citations
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June 2022 in “Frontiers in Bioengineering and Biotechnology” This study found that a hydrogel containing icariin enhanced wound healing and hair-follicle regeneration in vivo by promoting M2 macrophage polarization and modulating the BMP pathway, with treated skin defects showing improved recovery and new hair follicle development compared to untreated defects.
6 citations
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May 2021 in “Stem Cell Reviews and Reports” This study identified and characterized progenitor cells from equine feet that may play a role in the pathogenesis and recovery of laminitis, suggesting potential therapeutic targets for treatment.
6 citations
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October 2015 in “Experimental dermatology” This study found that adenine supplementation in cultured human follicle dermal papilla cells stimulated proliferation and reduced senescence, possibly through AMPK activation and increased cellular NAD+ levels.
5 citations
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January 2021 in “BioMed Research International” This study found that a noncrosslinked hyaluronic acid filler restored cell viability against UVB-induced cytotoxicity and increased VEGF secretion in human dermal papilla cells, suggesting potential for mesotherapy use after further research.
4 citations
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November 2020 in “BMC Dermatology” This study identified 374 eQTLs in scalp hair follicles associated with genes involved in metabolic, mitotic, immune processes, and responses to steroid hormones, contributing insights into genetic variation and hair traits.
3 citations
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January 2025 in “Biomaterials Science” In this study, blue light-irradiated nanovesicles derived from human adipose-derived stem cells enhanced dermal fibroblast proliferation and extracellular matrix synthesis, improving skin maintenance and hair follicle regeneration, suggesting a novel therapeutic strategy for skin and hair disorders.
3 citations
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January 2023 in “Agronomy” This research reported that KDML105 bran extract demonstrated antioxidant activities, reduced nitric oxide production, and influenced gene expression related to the hair cycle in cultured dermal papilla cells, suggesting potential as an anti-hair loss agent by supporting the anagen phase and angiogenesis.
3 citations
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November 2022 in “International journal of molecular sciences” This study reported that bio-pulsed avian-derived mesenchymal stem cell extracellular vesicles significantly improved cell proliferation, wound healing, and gene expression in human skin fibroblasts and hair follicle cells.
3 citations
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September 2021 in “Bulletin of the Korean Chemical Society” In this study, dimeric peptide derivatives were shown to enhance the proliferation of human follicle dermal papilla cells in vitro, particularly promoting the ERK1/2 pathway, suggesting potential for developing peptide-based treatments for hair regeneration.
3 citations
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June 2017 in “Journal of Physiology & Pathology in Korean Medicine” This study found that Puerariae Radix ethanol extracts increased the proliferation of human hair dermal papilla cells via ERK and Akt phosphorylation, suggesting potential benefits for alopecia treatment.
2 citations
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January 2022 in “BioMed Research International” The researchers concluded that baicalin may promote hair growth and follicle proliferation by activating the AKT pathway, suggesting its potential as a treatment for alopecia.
1 citations
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September 2023 in “Journal of cosmetic dermatology” This study suggests that Silybum marianum flower extract may promote hair growth and reduce hair loss by increasing proliferation and VEGF production in dermal papilla cells and suppressing cell senescence.
1 citations
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August 2016 in “Dermatology - Open Journal” In this study, the researchers found that optic atrophy 1 (OPA1) is involved in the transition between filamentous and rounded mitochondria in hair follicle dermal papilla cells, potentially influencing cellular energy dynamics.
June 2026 in “International Journal of Molecular Sciences” This study suggests that black ginseng concentrate protects human follicle dermal papilla cells against oxidative stress, potentially offering a natural approach to prevent cellular dysfunction linked to hair loss.
May 2026 in “Journal of Medicinal Chemistry” In this study, the authors developed a novel PROTAC named dAR-6–1, which demonstrated superior hair regeneration in an AGA mouse model compared to minoxidil, highlighting its promise as a therapy due to potent AR degradation and excellent skin permeability.
April 2026 in “Journal of the Korean Society of Cosmetology” This study found that Limosilactobacillus reuteri NCHBL-005, derived from honeybees, may promote hair growth via a novel non-androgenic mechanism involving the Wnt/β-catenin signaling pathway, as it increased hair follicle size and number in mice and influenced related gene expression in human follicle cells.
January 2026 in “Journal of Radiation Research” This study found that using human hair follicle dermal papilla cells, 53BP1 focus counting can estimate radiation doses from 50 mGy after 5 hours, and focus size analysis refines dose estimation for doses ≥ 500 mGy up to 96 hours.
January 2026 in “Applied Sciences” In this study, cyclic ADP-ribose (cADPR) treatment in human hair follicle dermal papilla cells was associated with increased intracellular calcium retention and activated anagen-related signaling without causing significant cytotoxicity, indicating its potential impact on hair growth processes.
December 2025 in “Cell Communication and Signaling” This study discovered that minoxidil affects hematopoiesis by downregulating wnt4, leading to suppression of hematopoietic stem and progenitor cells and alleviating MDS-like symptoms in zebrafish and mice, with hematologic safety achieved at optimized doses.
September 2025 in “Frontiers in Medicine” This study found that angiopoietin-1 significantly reduces apoptosis and promotes proliferation in human follicle dermal papilla cells under DHT-induced stress, suggesting its potential as a therapeutic candidate for androgenetic alopecia.
September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that Ang1 improved survival and proliferation in human follicle dermal papilla cells under DHT-induced stress, suggesting potential as a therapeutic candidate for androgenetic alopecia.
April 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that exosomes derived from human umbilical cord mesenchymal stem cells enhanced the growth of human hair dermal papilla cells by promoting cell cycle progression and activating PI3K and Akt-dependent pathways, indicating potential for hair loss treatment.
In this study, human hair dermal papilla cells were incubated with varying concentrations of umbilical cord-derived mesenchymal stem cell exosomes or minoxidil, and cell proliferation was assessed, showing significant results compared to the control.
April 2025 in “Journal of Biophotonics” This study found that 808 nm laser photobiomodulation altered mitochondrial respiration and enhanced osteogenic protein expression in human dental pulp stem cells, with the effects being dose-specific and more pronounced at 15 J/cm².
April 2025 in “Cellular and Molecular Biology” This study found that human dermal stem/progenitor cells demonstrated greater proliferation and differentiation potential than hair follicle dermal papilla cells, which showed increased expression of hair regeneration markers.
April 2025 in “International Journal of Molecular Sciences” In this study, exosomes derived from Iris germanica L. rhizomes (Iris-exosomes) were reported to alleviate oxidative stress and improve mitochondrial function in human follicle dermal papilla cells by activating the Wnt/β-catenin signaling pathway, suggesting potential benefits for hair loss treatment.
January 2025 in “Cosmetics” In this study, the researchers found that Astragalus sinicus extracts improved wound healing, reduced oxidative stress, and activated crucial signaling pathways in dermal papilla cells damaged by dihydrotestosterone, suggesting it may be a promising ingredient for hair loss treatment.
May 2024 in “Journal of functional foods” In this laboratory study, coffee bean residue extract was observed to promote the proliferation of human hair follicle dermal papilla cells by activating autophagy, showing potential for treating hair growth disorders and hair loss.