51 citations
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September 2012 in “Biomacromolecules” This study found that disulfide bonds in keratin increase its strength and toughness, with some loss of α-helical structure under load, highlighting their role in trichocyte α-keratin's mechanical properties.
May 2026 in “International Journal of Cosmetic Science” This study found that repeated exposure to ozonated water caused oxidative changes in hair proteins, lipids, and pigments, leading to altered hair properties, with minimal effects on shine and color.
August 2025 in “Applied Sciences” This study found that peroxide-rich plasma-activated water caused minimal morphological damage to hair, while nitrate-rich plasma-activated water induced significant damage, especially in porous hair types.
27 citations
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April 2018 in “Artificial Cells Nanomedicine and Biotechnology” This study reported that recombinant human hair keratins, K37 and K81, showed higher purity and enhanced fibrin clot formation compared to traditional extracts, reducing bleeding time and blood loss in rat injury models.
This study found that modern styling cosmetics can significantly alter hair structure through changes in interfacial chemistry and cohesion, particularly when applied to already damaged hair.
4 citations
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January 2015 in “Sen'i Gakkaishi” This study proposed a network model for the cross-linked structure of keratin-associated proteins in hair and wool fibers, suggesting notable differences between the two, potentially affecting hair fiber elasticity.
1 citations
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January 2013 in “PubMed” In this study, treating hair with thioglycolic acid was found to alter disulfide bond patterns in keratin-associated proteins, shifting them from an ellipsoidal to a near-spherical shape.
March 2010 in “International Journal of Cosmetic Science” This study found that oxidative treatment with peracetic acid dissociates some disulfide bonds in human hair fibers while maintaining the crystalline structure, suggesting different mechanisms stabilize different regions of intermediate filaments.
In this study, researchers developed vegan exosome-like vesicles from microalgae that mimic mammalian exosomes, demonstrating promising in vitro, ex vivo, and clinical effects such as improved wrinkle depth and elasticity, making them a potential alternative in cosmetic applications.
4 citations
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December 2020 in “Mammalian genome” This study found that pelage abnormalities in Harlequin mutant mice are linked to severe AIF deficiency and associated with altered expression of genes related to hair structure.
25 citations
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March 2017 in “Experimental Dermatology” This review discusses various aspects of hair follicle biology and highlights unresolved questions and potential new research avenues, but presents no new experimental findings.
10 citations
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January 2010 in “International journal of trichology” This study found that keratin-associated proteins form part of the developing exocuticle and a-layer in hair fiber cuticle cells, while cornified envelope proteins were absent.
2 citations
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September 2023 in “International journal of molecular sciences” This review summarizes the roles of matricellular proteins in skin stem cell niches, highlighting their contribution to stem cell fate, self-renewal, and potential implications for wound healing and aging.
March 2026 in “Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials” This study investigated the mechanical response of the human hair cuticle to strain and found that cuticular deformation directly corresponded with fiber elongation, revealing significant molecular-level changes in disulfide crosslinks but maintained structural stability, highlighting the role of the cuticle in stress resistance.
68 citations
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April 2014 in “Journal of Investigative Dermatology” This study identified a new S100 fused-type protein, scaffoldin, in reptiles and birds and suggests that SFTP-positive epithelia serve as scaffolds for the growth of various skin appendages, indicating a common evolutionary origin.
28 citations
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October 1985 in “The Journal of Cell Biology” This study identified two types of hard alpha-keratin filament assemblies in developing human hair follicles, which may help investigate the structural framework of mammalian keratin appendages.
17 citations
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September 2005 in “International Journal of Dermatology” African hair is more fragile due to its unique shape and internal structure.
15 citations
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January 2018 in “Advances in experimental medicine and biology” This review discusses recent advances in understanding the structural hierarchy of trichocyte keratins, including their heterodimeric structure and distinct conformations impacting hair growth, with no new experimental results reported.
June 2017 in “University of the Arts London Research Online (University of the Arts London)” This study compared the effects of three compounds on structural and sensory benefits for bleached hair when applied with or after bleaching, observing that their application may mitigate bleaching-induced damage.
208 citations
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December 2003 in “Journal of Investigative Dermatology” This study found that dermal papilla and peribulbar dermal sheath cup cells in mice can both induce hair follicle formation, suggesting they may have similar functional roles in hair growth.
854 citations
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February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.
2 citations
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December 2023 in “Royal Society of Chemistry eBooks” The book discussed in this abstract is a comprehensive guide to hair analysis, detailing the latest methods and applications across various fields such as toxicology and drug monitoring, designed for both newcomers and experts in the field.
13 citations
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March 2013 in “International Journal of Cosmetic Science” This study reports that the tetrapeptide AcSDKP significantly promotes skin and hair health in vitro and ex vivo, suggesting it could be used cosmetically to counteract skin aging and hair loss.
35 citations
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May 2011 in “Experimental Dermatology” This study found that hair follicles undergo significant molecular changes with age, notably a decline in keratins and keratin-associated proteins, which may contribute to age-related hair alterations.
30 citations
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August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that TGase 3 may contribute to hair fiber scaffolding by forming specific isopeptide bonds between keratin intermediate filaments and keratin-associated proteins.
7 citations
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July 2019 in “International Journal of Molecular Sciences” This study found that PGA-4HGF nanoparticles enhanced hair growth in mice more effectively than 4HGF alone by increasing anagen phase duration and dermal papilla cell proliferation.
29 citations
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August 2011 in “PubMed” This study describes how shotgun proteomics can identify over 300 proteins in hair shafts, potentially allowing for the diagnosis of diseases through noninvasive human proteome sampling.
2 citations
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January 2000 in “Elsevier eBooks” The document explains how hair is studied in forensics to identify its source and its role in criminal investigations.
47 citations
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June 1996 in “International Journal of Legal Medicine” This article discusses how drug molecules integrate into hair fibers, focusing on biological transport mechanisms and physicochemical factors, but reports no new experimental findings.
86 citations
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May 2002 in “Journal of Investigative Dermatology” This study characterized a new human keratin, hK6irs1, specifically found in the inner root sheath of hair follicles, which suggests its role in the structural integrity and guidance of growing hair shafts.