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GlossaryHair Matrix Keratinocytes

specialized cells producing keratin for hair growth

Hair Matrix Keratinocytes are specialized cells located at the base of the hair follicle. These cells are responsible for producing the keratin proteins that make up the hair shaft, essentially driving hair growth. They rapidly divide and differentiate, contributing to the formation and elongation of the hair strand.

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Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations, August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

Exogenous Stimulation with Eclipta Alba Promotes Hair Matrix Keratinocyte Proliferation and Downregulates TGF-β1 Expression in Nude Mice

research Exogenous Stimulation with Eclipta Alba Promotes Hair Matrix Keratinocyte Proliferation and Downregulates TGF-β1 Expression in Nude Mice

24 citations, December 2014 in “International Journal of Molecular Medicine”

Eclipta alba extract helps increase hair growth and decrease hair loss-related protein in mice.

research Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes Against Paclitaxel-Induced Damage Ex Vivo

1 citations, September 2023 in “Journal of Investigative Dermatology”

Melatonin may protect hair follicle cells from damage caused by a chemotherapy drug.

DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

research DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

July 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.

Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts

research Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts

June 2020 in “Journal of Investigative Dermatology”

Scientists successfully grew mini hair follicles using human skin cells, which could help treat baldness.

research Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD71 Positive Keratinocyte Cells

17 citations, February 2015 in “International Journal of Molecular Sciences”

A special mix from certain skin cells can help hair grow by making hair root cells grow faster and activating growth signals.

research DNA Dioxygenases TET Regulate Keratin Gene Expression and Enhancer Networks Within Lineage-Specific Gene Loci During Epidermal and Hair Follicle-Specific Keratinocyte Differentiation

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TET enzymes are important for skin and hair development by controlling gene activity in specific areas.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

30 citations, April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research Stimulatory Effect of Brazilian Propolis on Hair Growth Through Proliferation of Keratinocytes in Mice

18 citations, November 2014 in “Journal of Agricultural and Food Chemistry”

Brazilian propolis was found to speed up hair growth in mice by increasing the growth of skin cells that form hair.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations, January 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations, June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

research Thyrotropin Releasing Hormone: A New Player in Human Hair Growth Control

72 citations, October 2009 in “The FASEB journal”

TRH stimulates human hair growth and extends the hair growth phase.

research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

53 citations, January 2009 in “Journal of Investigative Dermatology”

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

research Red Ginseng Extract Promotes Hair Growth in Cultured Human Hair Follicles

49 citations, November 2014 in “Journal of Medicinal Food”

Red Ginseng Extract may help human hair grow by activating growth pathways and blocking negative effects of certain hormones.

research Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture

42 citations, March 2018 in “PLOS Biology”

Autophagy is important for human hair growth and health.

research Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

29 citations, March 2015 in “Journal of Investigative Dermatology”

Cyclosporine A promotes hair growth and prolongs the active growth phase in human hair follicles, but may work differently than in rodents.

research Activation of Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth

26 citations, July 2016 in “PLOS ONE”

Activating β-catenin in certain skin cells speeds up hair growth in mice.

research L-Carnitine-L-Tartrate Promotes Human Hair Growth In Vitro

26 citations, October 2007 in “Experimental Dermatology”

L-Carnitine-L-tartrate may help hair grow and prevent hair loss.

Protective Effect of Korean Red Ginseng Against Chemotherapeutic Drug-Induced Premature Catagen Development Assessed With Human Hair Follicle Organ Culture Model

research Protective Effect of Korean Red Ginseng Against Chemotherapeutic Drug-Induced Premature Catagen Development Assessed With Human Hair Follicle Organ Culture Model

19 citations, July 2015 in “Journal of Ginseng Research”

Korean Red Ginseng may protect against hair loss caused by chemotherapy.

research Topically Applied Nicotinamide Inhibits Human Hair Follicle Growth Ex Vivo

13 citations, December 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Nicotinamide applied to the scalp can slow down hair growth.

research The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in Hair Follicle Morphogenesis and Homeostasis

9 citations, April 2006 in “American Journal of Pathology”

SGK3 is essential for proper hair growth and health.

research An Extract of Leontopodium Alpinum Inhibits Catagen Development Ex Vivo and Increases Hair Density In Vivo

1 citations, May 2022 in “International Journal of Cosmetic Science”

Edelweiss extract can increase hair density and promote hair growth.

research Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth Ex Vivo

1 citations, January 2019 in “Skin Pharmacology and Physiology”

Eplerenone, a mineralocorticoid receptor antagonist, was found to promote hair growth in human hair follicles.

research IL-15 Prolongs Hair Growth and Acts as a Guardian of Human Hair Follicle Immune Privilege

July 2022 in “Journal of Investigative Dermatology”

IL-15 helps maintain hair growth and protects the immune status of hair follicles.

Estetrol Prolongs Anagen in Healthy Female Scalp Hair Follicles by Positively Modulating Dermal Papilla Functions and Generation of Progenitor Stem Cells Ex Vivo

research Estetrol Prolongs Anagen in Healthy Female Scalp Hair Follicles by Positively Modulating Dermal Papilla Functions and Generation of Progenitor Stem Cells Ex Vivo

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Estetrol may help prevent hair loss and promote hair growth in women.

research IL-9/IL-9R Signaling as a Novel Regulator of Human Hair Follicle Growth and Immune Privilege

April 2023 in “Journal of Investigative Dermatology”

IL-9/IL-9R signaling can negatively affect human hair growth and may be a target for treating hair loss conditions.

research Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Affect Stem Cells in Human Scalp Hair Follicles

November 2022 in “Journal of Investigative Dermatology”

Fish-derived collagen may help hair grow longer and affect hair stem cells, while bovine collagen could benefit hair stem cell maintenance, potentially aiding in hair loss conditions.

research Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Affect Stem Cells in Human Scalp Hair Follicles

September 2022

Collagen peptides may help maintain hair growth and could be beneficial for hair loss conditions.

research Controlling MTORC1 Activity as a Novel Therapeutic Strategy for Managing Human Hair Growth and Pigmentation

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking mTORC1 activity with rapamycin could help increase hair pigmentation and growth, potentially reversing gray hair.

research A Novel Cosmetic Anti-Hair Loss Approach: An Extract of Leontopodium Alpinum Inhibits Catagen Development

October 2021 in “Journal of Investigative Dermatology”

Edelweiss extract may help prevent hair loss and increase hair density.