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    Glossary Hair Follicle Organoids

    tiny, lab-grown structures mimicking natural hair follicles

    Hair Follicle Organoids are tiny, lab-grown structures that mimic the natural hair follicles found in the skin. Scientists create these organoids using stem cells, allowing them to study hair growth, hair loss conditions like alopecia, and test new treatments in a controlled environment.

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    1. Self‐organizing hair peg‐like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field Experimental Dermatology · 2019 · 26 citations
    2. Self-assembled complete hair follicle organoids by coculture of neonatal mouse epidermal cells and dermal cells in Matrigel Annals of translational medicine · 2022 · 4 citations
    3. Generation of human-induced pluripotent stem cell-derived adherent 3-dimensional skin hair-follicle organoids Organoid · 2022 · 2 citations
    4. Engineering immune-competent hair follicle microphysiological systems: from organoid assembly to dynamic immune modelling Frontiers in Bioengineering and Biotechnology · 2026
    5. Hypericin and berberine promote elongation of hair peg-like sprouting in hair follicle organoids via oxytocin signaling activation Scientific Reports · 2026
    6. Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip Advanced Science · 2026
    7. Hair follicle organoids: advances in construction, applications, and translational challenges Frontiers in Cell and Developmental Biology · 2026
    8. Advancements in hydrogel-based design and applications of hair follicle organoids Organoid Research · 2026
    9. Hair Follicle Organoids Using Human iPSC-Derived Ectodermal Precursor Cells for Hair Regenerative Medicine ACS Biomaterials Science & Engineering · 2026
    10. Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation Scientific Reports · 2024
    11. Effects of Exosomes Derived from Dermal Papilla Cells on Hair Follicle Stem Cells and Hair Follicle Organoids Yokohama National University Repository (Yokohama National University) · 2022
    12. 773 Generation of human hair follicle organoids in vitro and ex vivo by co-culture of primary human hair matrix keratinocytes and dermal papilla fibroblasts Journal of Investigative Dermatology · 2020
    13. Katsuwonus pelamis heart hydrolysates promote hair growth in 3-dimensional human hair follicle organoids and in mice Food Science and Biotechnology · 2026
    14. Potential application of PBM use in hair follicle organoid culture for the treatment of androgenic alopecia Materials Today Bio · 2023
    15. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018 · 169 citations
    16. Establishment of an in vitro organoid model of dermal papilla of human hair follicle Journal of Cellular Physiology · 2018 · 44 citations
    17. The empowering influence of air-liquid interface culture on skin organoid hair follicle development Burns & Trauma · 2024 · 9 citations
    18. 0887 Long-lived and genetically-diverse skin organoids derived from murine adult hair follicle stem cells Journal of Investigative Dermatology · 2025
    19. Modeling of solar UV-induced photodamage on the hair follicles in human skin organoids Journal of tissue engineering · 2024
    20. Reconstructing hair follicle pigmentary unit using organoids and bioprinting International Journal of Bioprinting · 2026
    21. A procedure for the culture of hair follicles as functionally intact organoids Clinics in Dermatology · 1988 · 5 citations
    22. Matrix-free cryo-microneedles array patch for 3D hair follicle organoids delivery` and rapid hair regeneration Materials Today Bio · 2026
    23. The development of an in vitro human hair follicle organoid with a complexity similar to that in vivo Biomedical materials · 2024
    24. Proliferation and differentiation of organoid hair follicle cells co-cultured with fat cells in collagen gel matrix culture British Journal of Dermatology · 1998 · 30 citations
    25. Cultivation of Murine Hair Follicles as Organoids in a Collagen Matrix Journal of Investigative Dermatology · 1987 · 87 citations
    26. Matrix-free cryo-microneedles array patch for 3D hair follicle organoids delivery and rapid hair regeneration SSRN Electronic Journal · 2025
    27. Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems Stem Cell Research & Therapy · 2019 · 17 citations
    28. Hair Follicle Morphogenesis During Embryogenesis, Neogenesis, and Organogenesis Frontiers in Cell and Developmental Biology · 2022 · 4 citations
    29. Organoid-loaded core-shell cryomicroneedles induce biomimetic follicular units and hair regeneration Bioactive Materials · 2026
    30. Unlocking Hair Follicles as Drug Reservoirs: Advances in Transfollicular Drug Delivery Zenodo (CERN European Organization for Nuclear Research) · 2026