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    Glossary Hair Follicle Epithelium

    layer of cells lining the hair-producing cavity in skin

    The hair follicle epithelium is the layer of cells that lines the hair follicle, which is the small cavity in the skin from which hair grows. This epithelium plays a crucial role in the growth, cycling, and regeneration of hair, and it includes various specialized cells that contribute to the formation and maintenance of the hair shaft.

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    1. Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen American Journal of Pathology · 2003 · 91 citations
    2. VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro Journal of Dermatological Science · 2013 · 35 citations
    3. Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment Stem cell research & therapy · 2021 · 14 citations
    4. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance 2019 · 11 citations
    5. Three-dimensional ultrastructural analysis of human skin with the arrector pili muscle interacting with the hair follicle epithelium Scientific Reports · 2025 · 1 citations
    6. Evidence for murine cutaneous immune surveillance localized to hair follicle epithelium Frontiers in Cell and Developmental Biology · 2026
    7. 495 OR2AT4 activation by a synthetic odorant, stimulates dermcidin production in human hair follicle epithelium and increases follicular resistance to bacterial contamination: A novel antimicrobial folliculitis therapy? 2019
    8. Nonviral in Situ Green Fluorescent Protein Labeling and Culture of Primary, Adult Human Hair Follicle Epithelial Progenitor Cells Stem Cells · 2009 · 43 citations
    9. Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis JCI Insight · 2025 · 1 citations
    10. Scaffolds for epithelial and hair follicle regeneration Elsevier eBooks · 2019 · 1 citations
    11. Hair follicle-derived epithelial sheet has potential in vitiligo treatment medRxiv · 2026
    12. 09-P006 Epithelial–mesenchymal interactions promote hair follicle neogenesis and a new stem cell niche in adult corneal epithelium Mechanisms of Development · 2009
    13. Solid basal cell epithelioma (BCE) possibly originates from the outer root sheath of the hair follicle. PubMed · 1993 · 61 citations
    14. (Neuro-)endocrinology of epithelial hair follicle stem cells Molecular and Cellular Endocrinology · 2008 · 42 citations
    15. 621 An apple stem cell-derived extract increases epithelial stem cells number in the hair follicle bulge Journal of Investigative Dermatology · 2019
    16. 255 Bone morphogenetic proteins are critical factors for hair follicle epithelial–mesenchymal interactions in androgenetic alopecia Journal of Investigative Dermatology · 2017
    17. Characterization of Epithelial Hair Follicle Stem Cells in Lichen Planopilaris and Folliculitis Decalvans Through Keratin 19 Expression American Journal of Dermatopathology · 2025
    18. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
    19. A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle Journal of Investigative Dermatology · 2002 · 86 citations
    20. ILK modulates epithelial polarity and matrix formation in hair follicles Molecular biology of the cell · 2013 · 22 citations
    21. Fabrication and characterization of epithelial scaffolds for hair follicle regeneration Tissue Engineering and Regenerative Medicine · 2012 · 4 citations
    22. 874 Chromatin architectural protein CTCF controls epidermal barrier formation, hair follicle fate maintenance and suppresses inflammatory responses in the skin epithelium Journal of Investigative Dermatology · 2017
    23. The Krüppel-like Factor Epiprofin Is Expressed by Epithelium of Developing Teeth, Hair Follicles, and Limb Buds and Promotes Cell Proliferation Journal of Biological Chemistry · 2003 · 88 citations
    24. An efficient method for isolation of hair papillae and follicle epithelium from human scalp specimens 1993 · 8 citations
    25. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    26. Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells into Corneal Epithelial-like Cells Stem Cells · 2008 · 162 citations
    27. Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges BioEssays · 2014 · 106 citations
    28. Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering Journal of Dermatological Science · 2013 · 57 citations
    29. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions Journal of Investigative Dermatology · 2015 · 56 citations
    30. In vitro skin models to study epithelial regeneration from the hair follicle PLoS ONE · 2017 · 19 citations