184 citations
,
November 2014 in “Developmental Cell” This study identifies a bipotent stem cell in adult hair follicles that self-renews and contributes to dermal sheath and papilla cell populations, potentially aiding hair regrowth after injury, disease, or aging.
37 citations
,
April 2017 in “npj Regenerative Medicine” This study found that platelet-derived growth factor signaling is crucial for maintaining the hair follicle dermal stem cell pool and supporting their regenerative capacity.
30 citations
,
April 2017 in “Experimental Dermatology” This review explores the role of hair follicle dermal stem cells in skin regeneration and restorative therapies, but it reports no new experimental results.
16 citations
,
March 2019 in “Experimental dermatology” This study found that injury affects the behavior of hair follicle dermal stem cells, steering them towards recruitment into the dermal papilla, a shift influenced by the hair cycle stage.
April 2018 in “Journal of Investigative Dermatology” This study reports that in aged mice, hair follicle dermal stem cells exhibit diminished self-renewal and preferential differentiation into dermal sheath cells, contributing to age-related hair loss.
September 2015 in “International Society of Hair Restoration Surgery” This article discusses the role of hair follicle stem cells in potential breakthroughs for hair cloning and follicular cell implantation, but reports no new clinical findings.
January 2017 in “PRISM (University of Calgary)” This study identifies unique gene expression patterns in specialized fibroblasts within adult hair follicles, which advances understanding of their role in tissue regeneration.
151 citations
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February 2006 in “Stem Cells and Development” This study found that hair follicle-derived dermal stem cells and bone marrow mesenchymal stem cells have similar growth, differentiation capabilities, and surface marker expressions, suggesting hair follicles could be accessible sources for mesenchymal stem cells.
10 citations
,
January 2016 in “Annals of Dermatology” This article discusses the factors contributing to acne and reports no new findings, focusing on the role of sebaceous lipids and associated processes.
January 2022 in “Figshare” In this study, researchers found that dermal papilla cell exosomes can enhance hair follicle stem cell proliferation and reduce apoptosis through the Wnt3a/β-catenin signaling pathway, offering insights for potential hair problem treatments.
3 citations
,
August 2018 in “Stem cells international” This study found that cultured hair follicle dermal cells support maintenance and potentially aid in the clinical application of pluripotent and haematopoietic stem cells.
January 2008 in “Durham e-Theses (Durham University)” This study observed that stem cells from the hair follicle dermis share similarities with bone marrow-derived mesenchymal stem cells and have potential to form neural-like cells under specific conditions.
95 citations
,
January 2012 in “British Journal of Dermatology” This study found that androgens inhibit hair follicle stem cell differentiation by disrupting the Wnt signalling pathway in dermal papilla cells, but Wnt activation can restore differentiation.
42 citations
,
February 2017 in “Scientific Reports” In this study, researchers differentiated induced pluripotent stem cells into cells with dermal papilla-like properties, demonstrating their potential role in hair follicle bioengineering and drug testing for hair growth.
January 2026 in “Materialia” In this study, porcine collagen acellular dermal matrix scaffolds combined with mice platelet-rich plasma were associated with increased hair density and follicle regeneration in mice with alopecia, suggesting a potential therapeutic approach.
37 citations
,
May 2016 in “Scientific Reports” In this study, the researchers found that using a core-shell assembly of adipose-derived stem cells and dermal papilla cells reconstructed hair follicle cellular arrangements more effectively than mixed assemblies, enhancing hair formation in vivo.
6 citations
,
July 2022 in “World journal of stem cells” This study found that human mesenchymal stem cell-derived extracellular vesicles promote the proliferation and migration of hair follicle cells and increase hair shaft elongation in cultured human hair follicles.
April 2017 in “Journal of Investigative Dermatology” This study found that human iPSC-derived dermal papilla precursor cells can regenerate hair follicle structures, offering a potential new treatment approach for permanent alopecia.
This review discusses recent advances in using stem cells for skin repair and regeneration after severe burn injuries, but it reports no new clinical results.
330 citations
,
December 2009 in “Cell stem cell” This study suggests that skin-derived precursors from Sox2(+) hair follicle dermal cells have the potential to function as dermal stem cells, supporting hair morphogenesis, dermal maintenance, and wound-healing.
17 citations
,
December 2019 in “Stem Cell Research & Therapy” This study found that their system effectively supports the rapid formation of human hair follicle organoids, providing a platform for studying hair regeneration and drug screening.
2 citations
,
January 2022 in “Oxidative Medicine and Cellular Longevity” This study suggests that exosomes from dermal papilla cells can regulate hair follicle stem cell proliferation via the Wnt3a/β-catenin signaling pathway, potentially informing treatment for human hair problems.
68 citations
,
August 2014 in “Stem Cells Translational Medicine” This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.
This study showed that in mice, anti-inflammatory macrophages are crucial for hair follicle regeneration in response to skin injury by activating stem cells and promoting hair growth.
101 citations
,
March 2019 in “Cell Stem Cell” This study found that Oncostatin M, via JAK-STAT5 signaling, keeps hair follicle stem cells inactive, and its removal leads to hair growth initiation in mice.
71 citations
,
January 2019 in “International journal of biological sciences” This study proposes the miR-22-5p-LEF1 axis as a novel pathway that may regulate hair follicle stem cell proliferation.
26 citations
,
February 2012 in “Journal of Investigative Dermatology” This study found that dermal papilla cells from human hair follicles can be reprogrammed into induced pluripotent stem cells, but their efficiency is similar to that of fibroblasts, unlike in mice.
6 citations
,
September 2009 in “European journal of histochemistry” This study found that CD90+ stem cells with fibroblast-like morphology are present in the lower part of the anagen hair follicle in dogs.
1 citations
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December 2021 in “Development & Reproduction” This study found that FPR2 knockout mice experienced excessive hair loss and abnormal hair follicle structures, suggesting FPR2's protective role in hair regeneration through stem cell activity regulation.
July 2025 in “Biotechnology and Bioprocess Engineering” This study found that Camellia japonica seed extract promotes hair growth by preventing premature cellular senescence and enhancing the activity of hair follicle stem cells in cases of pattern hair loss.