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GlossaryAnagen Hair Follicles

phase where hair actively grows

Anagen hair follicles, also known as growing hair follicles or active hair follicles, are in the phase of the hair growth cycle where the hair is actively growing. This phase can last anywhere from 2 to 7 years, during which the hair shaft is continuously produced by the follicle, resulting in longer hair. This is the most prolonged phase of the hair cycle and is crucial for determining the length of the hair.

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Research

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research Structural Optimization of Pep7, a Small Peptide Extracted from Epimorphin, for Effective Induction of Hair Follicle Anagen

9 citations, August 2005 in “Experimental Dermatology”

Modified pep7, named EPM peptide, effectively promotes hair growth at low concentrations and works well with minoxidil.

research Epimorphin Acts to Induce Hair Follicle Anagen in C57BL/6 Mice

24 citations, November 2003 in “The FASEB Journal”

Epimorphin helps start hair growth in mice.

Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice

research Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice

33 citations, September 2017 in “Molecules”

Red ginseng oil and its components help promote hair regrowth and could treat hair loss.

Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

research Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

31 citations, September 2013 in “Stem Cells”

Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.

research Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration

30 citations, February 2017 in “Histochemistry and Cell Biology”

TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.

research Effects of UV-Induced Photoaging on the Hair Follicle Cycle of C57BL6/J Mice

10 citations, May 2021 in “Clinical, cosmetic and investigational dermatology”

UV exposure causes hair thinning, graying, and changes in hair growth cycles in mice.

research Metabolomics Reveals Metabolites Associated with Hair Follicle Cycle in Cashmere Goats

May 2024 in “BMC veterinary research”

Metabolites and diet affect hair growth cycles in cashmere goats.

research The G-Protein Coupled Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.

research Autophagy Induces Hair Follicle Stem Cell Activation and Hair Follicle Regeneration by Regulating Glycolysis

January 2024

Autophagy helps activate hair stem cells and hair growth by changing their energy use to glycolysis.

research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression

96 citations, October 2000 in “The FASEB Journal”

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

research Hair Growth Promoting Effect of Houttuynia Cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells

16 citations, October 2019 in “Biological & Pharmaceutical Bulletin”

Houttuynia cordata extract may help hair grow by improving cell survival and increasing cell growth.

research SIRT7 Activates Quiescent Hair Follicle Stem Cells to Ensure Hair Growth in Mice

38 citations, July 2020 in “EMBO journal”

SIRT7 protein is crucial for starting hair growth in mice.

Thymosin β4 Identified by Transcriptomic Analysis from Hair Follicle Anagen to Telogen Promotes Proliferation of Secondary Hair Follicle Dermal Papilla Cells in Albas Cashmere Goat

research Thymosin β4 Identified by Transcriptomic Analysis from Hair Follicle Anagen to Telogen Promotes Proliferation of Secondary Hair Follicle Dermal Papilla Cells in Albas Cashmere Goat

3 citations, March 2020 in “International Journal of Molecular Sciences”

Thymosin β4 helps increase hair growth in Cashmere goats.

research Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations

41 citations, April 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Deleting MED1 in skin cells causes hair loss and skin changes.

research mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration

71 citations, January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology”

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

research Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors

66 citations, December 2013 in “Nature Cell Biology”

Inactive hair follicle stem cells help prevent skin cancer.

research Estrogen Leads to Reversible Hair Cycle Retardation Through Inducing Premature Catagen and Maintaining Telogen

42 citations, July 2012 in “PLOS ONE”

Estrogen can temporarily slow down hair growth but this can be reversed.

research Therapeutic Strategies for Treating Hair Loss

42 citations, March 2006 in “Drug Discovery Today: Therapeutic Strategies”

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

research Expression Profiling Reveals Genes Involved in the Regulation of Wool Follicle Bulb Regression and Regeneration in Sheep

19 citations, April 2015 in “International Journal of Molecular Sciences”

The research identified genes and pathways important for sheep wool growth and shedding.

research CD133-Positive Dermal Papilla-Derived Wnt Ligands Regulate Postnatal Hair Growth

15 citations, July 2016 in “Biochemical Journal”

Wnt proteins from certain skin cells are crucial for normal hair growth and renewal.

research A Pair of Transmembrane Receptors Essential for the Retention and Pigmentation of Hair

11 citations, May 2012 in “Genesis”

Bmpr2 and Acvr2a receptors are crucial for hair retention and color.

research 3D Bioprinting of Calcium Molybdate Nanoparticles-Containing Immunomodulatory Bioinks for Hair Regrowth

3 citations, June 2023 in “Nano today”

A special bioink with nanoparticles helps regrow hair by reducing inflammation and promoting hair growth signals.

research Enhancement of Skin Rejuvenation and Hair Growth Through Novel Near-Infrared LED Lighting: In Vitro and In Vivo Study

April 2024 in “Lasers in medical science”

Near-infrared LED light improves skin rejuvenation and hair growth better than white LED light.

research In Vivo and In Vitro Hair Growth-Promoting Effect of Silver and Iron Nanoparticles Synthesized via Blumea Eriantha DC Plant Extract

11 citations, September 2020 in “Journal of Cosmetic Dermatology”

Silver nanoparticles can significantly promote hair growth.

research The Basic Science of Hair Biology

29 citations, September 2012 in “Dermatologic Clinics”

Hair disorders are caused by a complex mix of biology, genetics, hormones, and environmental factors, affecting hair growth and leading to conditions like alopecia.

research Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles

21 citations, May 2022 in “Frontiers in Cell and Developmental Biology”

Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.

Analysis of the Expression Pattern of the Carrier Protein Transthyretin and Its Receptor Megalin in the Human Scalp Skin and Hair Follicles: Hair Cycle-Associated Changes

research Analysis of the Expression Pattern of the Carrier Protein Transthyretin and Its Receptor Megalin in the Human Scalp Skin and Hair Follicles: Hair Cycle-Associated Changes

6 citations, November 2010 in “Histochemistry and cell biology”

The proteins transthyretin and megalin are more present in the growth phase of hair, suggesting they might affect hair health and growth.