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This review explores the potential, challenges, and recent advancements of dissolving microneedles in drug delivery, summarizing their varied applications and current limitations without providing new clinical results.

Smart microneedles using advanced tech could improve psoriasis treatment.

This source reviews advancements in microneedle-based cosmeceutical delivery, discussing new technologies and highlighting a burgeoning area of research involving microneedling combined with stem cell delivery for anti-aging, without finding measurable changes in skin barrier function or appearance during the study period.

This review outlines the development, applications, and challenges of microneedle-based drug delivery from 2000-2019, particularly highlighting fabrication techniques, but reports no new clinical results.

This minireview discusses the mechanisms of facial aging, examines current literature, and proposes filler injection protocols, but it reports no new clinical results.

Combining topical dutasteride with microneedling is more effective for hair growth than microneedling alone.

This review summarizes the application of microneedles in treating various skin diseases and highlights challenges like low drug loading, noting no new clinical results are reported.

This review discusses advancements in the use of microneedle arrays and nanoparticles for transdermal delivery of therapeutics, noting challenges in overcoming the skin barrier and summarizing recent clinical trial achievements in areas like cancer therapy and gene therapy.

In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.

This review highlights how advanced nanocarrier and microneedle-based transdermal drug delivery strategies can potentially improve the treatment of skin diseases by enhancing site-specific drug delivery, increasing skin penetration, and reducing systemic toxicity compared to conventional methods.

This study reviews recent advancements in microneedles made from PLGA, highlighting their use in delivering vaccines, drugs, and proteins through the skin with minimal invasiveness, and discusses the challenges and future potential of these delivery systems.

This study found that a ceria nanozyme-integrated microneedles patch accelerated hair regeneration in an androgenetic alopecia mouse model more effectively than minoxidil, with reduced application frequency and minimal skin damage.

This study reported that a magneto-responsive transdermal microneedle system delivered Minoxidil effectively and significantly increased hair density by 800% in mice with androgenetic alopecia after 10 days.

This study found that using an electrical microneedling device enhanced the penetration of liposomal melanin-fluorescein into hair structures and widened the follicular infundibulum in ex vivo human skin models.

This review examines microneedle patches for drug delivery, detailing their designs, materials, manufacturing methods, and potential advantages, but reports no new clinical results.

This study developed an antimicrobial microneedle patch for delivering apoptotic vesicles to treat infected wounds, which was found to effectively reduce bacterial growth and accelerate scarless healing, including the rapid formation of mature hair follicles in just 8 days, a previously unreported early outcome.

This review highlights that the combination of ultrasound and microneedles can enhance transdermal drug delivery by using physical and energy-driven mechanisms to improve drug penetration into deeper skin layers, with implications for precision medicine and chronic disease treatments.

This study introduced hydrogel microneedles loaded with palladium nanoparticles, which utilize the inherent cytotoxicity of polyethyleneimine to enhance the effectiveness of doxorubicin in treating melanoma, achieving a tumor inhibition rate of up to 98% in a murine model.

This study reports that a novel ketoconazole-loaded microneedle array significantly enhances drug delivery and retention in the skin, demonstrating improved hair growth in animal models, suggesting a promising treatment for androgenic alopecia that addresses current topical therapies' limitations.

This review discusses the integration of nanoparticles with microneedles to improve drug delivery through enhanced stability, bioavailability, and controlled release, noting ongoing challenges with stability, scalability, and safety.

This review provides an overview of microneedle-assisted photomedicine, detailing diagnostic and therapeutic strategies, design principles, and challenges for translating this approach to skin disease management.

This review highlights the potential of microneedle devices in dermatology for conditions like skin aging and autoimmune skin diseases, emphasizing their ability to facilitate targeted drug delivery by creating temporary skin pathways.

This review summarizes the positive clinical response of using platelet-rich plasma as an adjuvant in skin rejuvenation treatments, with no identifiable complications, suggesting a promising outlook for its future use.

In this study involving 20 participants with alopecia areata, microneedling was reported to clinically improve hair density and growth in affected areas, with results starting around one month and concluding three months after the final treatment session.

This study proposes an innovative treatment for stretch marks by combining skinbooster and microneedling techniques, which induce tissue remodeling and collagen synthesis, and suggests using confocal microscopy as a valuable tool for monitoring skin changes in aesthetic dermatology.

This study found that fractional Er:YAG laser combined with platelet-rich plasma resulted in greater skin repigmentation in patients with localized stable vitiligo compared to microneedling with platelet-rich plasma, with fewer side effects reported in the laser group.

In this open uncontrolled study on microneedling as an adjuvant therapy for frontal fibrosing alopecia, researchers observed stable frontotemporal recession measurements while patients reported improvements in quality of life and a reduction in inflammatory activity parameters.

This review explores quercetin's potential in multifunctional theranostic systems, highlighting its bioactivity and the challenges of improving its clinical application through innovative strategies like nanoencapsulation, while noting that research in this area is underdeveloped.

This study found that a microneedle system delivering VEGF and Ritlecitinib improved hair regeneration in mice with androgenetic alopecia, showing faster anagen onset and better hair quality compared to minoxidil.

A dissolving microneedle patch with dutasteride offers effective, long-lasting hair loss treatment with fewer side effects.