This review summarizes the composition, bioactive functions, and potential industrial applications of rice bran polysaccharides, focusing on how extraction methods and modifications impact their biological activities.
June 2026 in “Nature Communications” This study found that in stretch-mediated tissue expansion, fibroblasts adopt an embryonic-like, low-collagen state that enhances epidermal stem cell renewal, supporting coordinated skin expansion crucial for reconstructive surgeries.
April 2026 in “Nanomaterials” This perspective study suggests that plant-derived extracellular vesicles could advance the use of Ayurvedic medicinal plants in nanomedicine by enhancing their therapeutic potential and guiding future research.
February 2026 in “Materials” This study evaluated Humulus lupulus (hops) extract in cosmetic formulations and found it to maintain antioxidant and anti-irritant properties, reducing erythema by 10% after three weeks of use, supporting its potential for skin health improvement in plant-based cosmetics.
January 2026 in “Bioengineering” In this review, various expression systems for synthesizing recombinant collagen are compared, highlighting their efficiency, modification capabilities, and cost. Key purification techniques are also analyzed, and challenges like reducing R&D costs and improving safety protocols are identified.
October 2025 in “Materials Today Bio” In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.
September 2025 in “Science Advances” This study reports that PADI4, an enzyme involved in posttranslational protein modifications, regulates progenitor cell transitions in hair follicle development by repressing transcription and interacting with translational and ribosomal processes.
September 2025 in “Molecules” This study found that Camellia oleifera leaf extracts, especially the 50% ethanolic extract, have significant antioxidant activity and may offer promising bioactive compounds for cosmetic and pharmaceutical uses.
August 2025 in “International Journal of Molecular Sciences” This study found that compounds isolated from Osmanthus fragrans var. aurantiacus demonstrated antioxidative and anti-inflammatory activities, potentially offering therapeutic benefits for inflammatory bowel diseases by inhibiting COX-2 and iNOS enzymes and blocking ERK 1/2 MAPK signaling.
June 2025 in “Materials Today Bio” In this study, a silk fibroin hydrogel containing recombinant NT3 was found to promote scar-less wound healing in a mouse skin injury model by enhancing type III collagen expression and inducing hair follicle formation.
June 2025 in “Rapid Communications in Mass Spectrometry” In this study, researchers developed a simplified and reliable method to prepare human hair shaft samples, achieving over 75% protein extraction efficiency and improved keratin sequence coverage, with the approach showing high reproducibility across different labs and operators.
February 2025 in “BMC Veterinary Research” This study examined proteomic changes in Inner Mongolia cashmere goat skin, finding 631 proteins differentially regulated during hair growth stages; key keratin proteins, crucial for hair follicle development, were localized in secondary hair follicles.
In this study, aqueous and aqueous-alcoholic extracts of Ajuga reptans showed promising hepatoprotective and wound-healing properties, with significant effects observed in experimental models, suggesting potential for development into official medicinal products pending further research.
January 2025 in “Open Medicine” This review discusses the connection between acne and metabolic syndrome, noting shared pathogenic mechanisms and suggesting integrated management strategies without presenting new clinical results.
December 2024 in “Frontiers in Pharmacology” In this study, human cell models of hair follicles showed that araliadiol, a plant-derived polyacetylene compound, promotes hair growth through the p38/PPAR-γ signaling pathway, suggesting its potential as a new drug candidate for alopecia treatment.
June 2024 in “European Journal of Pharmaceutics and Biopharmaceutics” This study reported that using photoacoustic waves to enhance transdermal delivery of encapsulated minoxidil can significantly increase hair growth while reducing treatment frequency and systemic side effects.
May 2024 in “Proteome science” This study found that the PLEE method increased hair protein extraction efficiency threefold and that bleaching hair reduced the coverage of keratin and associated proteins, leading to poorer hair quality, though it did not affect the overall protein identification.
December 2023 in “The journal of physical chemistry. B (1997 : Online)” This study explored the potential of human hair keratin as a filtration material, finding that it may effectively absorb the pollutants diclofenac and perfluorobutanesulfonate. The researchers reported significant binding affinities through molecular simulations, supporting further investigation into keratin's use for water purification.
September 2023 in “Animals” In this study, researchers used proteomic and metabolomic analyses to explore hair follicle development in embryonic cashmere goats, identifying significant roles for the oxytocin signalling pathway and associated networks in this process.
June 2023 in “Journal of Biological Chemistry” In this study, the authors identified and characterized the Get3d protein, conserved across plants and photosynthetic bacteria, which localizes to the chloroplast in Arabidopsis thaliana and potentially plays a role in tail-anchored protein targeting, linked to photosynthesis homeostasis.
April 2023 in “Clinical Chemistry and Laboratory Medicine” The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.
September 2022 in “Frontiers in Bioengineering and Biotechnology” This study reports that taxifolin from enzymatic hydrolysis effectively regulates dermal papilla cell apoptosis and promotes hair growth by increasing IGF-1 and reducing TGF-β1, though it shows less inhibition of DHT compared to minoxidil.
June 2022 in “Pflügers Archiv - European Journal of Physiology” This study found that the deletion of soluble epoxide hydrolase (sEH) in mice altered the hair follicle cycle and increased hair growth through effects on hair follicle stem and matrix cells.
April 2022 in “Molecules” This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.
This study found that in early retinal neurogenesis in mice, the transcription factor Lhx2 regulates Sonic Hedgehog signaling by controlling expression of pathway genes like the co-receptors Gas1 and Cdon.
April 2011 in “한국생물공학회 학술대회” This study found that an anti-atopic lotion containing fucoidan helped heal skin damage in hairless mice with atopic dermatitis by reducing skin thickness and modulating immune responses.
81 citations
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October 2023 in “Bioactive Materials” This review highlights the promising potential of 3D printing for creating microneedles with precise customization and improved performance compared to traditional micromolding, emphasizing applications in personalized medical devices and advancements in biomedical fields.
40 citations
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July 2024 in “Bioengineering” This review found significant progress in 3D bioprinting for surgery, noting advances in creating complex tissue constructs, while highlighting ongoing challenges like vascularization and integration with host tissue, emphasizing the need for further research and regulatory development.
25 citations
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November 2022 in “Frontiers in Bioengineering and Biotechnology” This review discusses the integration of biodegradable biomaterials with drugs and stem cells for diabetic wound repair, but reports no new clinical results and highlights the need for further translation to clinical practice.
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April 2008 in “Fertility and sterility” In this study, pioglitazone treatment in insulin-resistant PCOS patients decreased relative 5alpha-reductase activity without significantly affecting cortisol levels or urinary cortisol excretion.