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    Did you mean Glycogen Synthase Kinase-3 Inhibitor?
    Glossary Glycogen Synthase Kinase-3 Inhibitor

    compound that blocks the enzyme GSK-3, affecting cell processes

    A Glycogen Synthase Kinase-3 Inhibitor (GSK-3 Inhibitor) is a type of compound that blocks the activity of the enzyme glycogen synthase kinase-3 (GSK-3). This enzyme is involved in various cellular processes, including the regulation of glycogen metabolism, cell division, and signaling pathways. Inhibiting GSK-3 has potential therapeutic applications for conditions like Alzheimer's disease, diabetes, and certain types of cancer, as well as promoting hair growth in cases of alopecia.

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    Research 30 of 769

    1. Discovery and Optimization of Novel Pyridines as Highly Potent and Selective Glycogen Synthase Kinase 3 Inhibitors 2019
    2. Influencing hair regrowth with EGCG by targeting glycogen synthase kinase-3β activity: a molecular dynamics study Journal of Receptors and Signal Transduction · 2025
    3. Sustained release of inhibitor from bionic scaffolds for wound healing and functional regeneration Biomaterials Science · 2020 · 8 citations
    4. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    5. Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection Cell Host & Microbe · 2016 · 133 citations
    6. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012 · 85 citations
    7. GSK-3 Inhibitors: Recent Developments and Therapeutic Potential Current signal transduction therapy · 2008 · 3 citations
    8. Human placental extract exerts hair growth-promoting effects through the GSK-3β signaling pathway in human dermal papilla cells International Journal of Molecular Medicine · 2015 · 20 citations
    9. Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice International Journal of Molecular Medicine · 2018 · 23 citations
    10. Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells Current Issues in Molecular Biology · 2023
    11. Vitamin B12 Activates the Wnt-Pathway in Human Hair Follicle Cells by Induction of <i>beta</i>-Catenin and Inhibition of Glycogensynthase Kinase-3 Transcription Journal of Cosmetics, Dermatological Sciences and Applications · 2011 · 4 citations
    12. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    13. In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides) Frontiers in physiology · 2022 · 6 citations
    14. Microcirculation-Promoting Effect of Escin on Cutaneous Tissue via Gsk3β Down-Regulation Current Issues in Molecular Biology · 2025 · 1 citations
    15. Effects of Allium hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells Plants · 2023 · 2 citations
    16. Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells Molecules · 2022
    17. Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways Archives of dermatological research · 2024
    18. The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis American Journal of Pathology · 2006 · 9 citations
    19. Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    20. Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites Frontiers in Neuroendocrinology · 2020 · 18 citations
    21. The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits 2020
    22. Hair Follicle Reconstruction and Stem Cells InTech eBooks · 2017 · 2 citations
    23. iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice Biochemical and Biophysical Research Communications · 2018 · 3 citations
    24. Nouvelles thérapeutiques dans la prise en charge de l’alopécie androgénétique HAL (Le Centre pour la Communication Scientifique Directe) · 2025
    25. Phosphatidylinositol 3-Kinase/Akt-Dependent and -Independent Protection Against Apoptosis in Normal Human Melanocytes Journal of Investigative Dermatology · 2004 · 16 citations
    26. Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways Frontiers in pharmacology · 2018 · 14 citations
    27. High doses of cobalt inhibited hair follicle development in Rex Rabbits World rabbit science · 2019 · 1 citations
    28. Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men Advances in Experimental Medicine and Biology · 2017 · 31 citations
    29. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately Stem Cell Research & Therapy · 2015 · 113 citations
    30. Hétérogénéité tumorale du cancer de la prostate et infection par le SARS-CoV2 : une relation complexe impliquant les vésicules extracellulaires et le récepteur des androgènes SPIRE - Sciences Po Institutional REpository · 2023