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Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Adrenal disorders can cause lasting brain and behavior issues in children.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Inhaled steroids in children may cause excessive hair growth and not always go away after stopping the medication.

A dog developed skin issues from too many steroids, but reducing steroids and using a specific treatment fixed the problems.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Rare adrenal cancers that secrete androgens or estrogens have a poor prognosis and are treated primarily with surgery.

The document concludes that careful history and physical exams are crucial for accurately diagnosing polycystic ovary syndrome and distinguishing it from other similar conditions.

Hormone imbalances from the pituitary, thyroid, and adrenal glands can cause infertility, but treating these disorders can improve fertility.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

The cause of atypical Cushing's syndrome in dogs, possibly linked to sex hormones, is not yet proven.

Blocking the mineralocorticoid receptor can help treat skin thinning caused by steroids.

Glucocorticoids can cause various health issues, but some treatments may help reduce these effects.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Different women's hair and skin glands respond to hormones in varied ways, which can cause unwanted hair growth even with normal hormone levels, and more research is needed to treat this effectively.

Some conditions mimic PCOS symptoms and need careful diagnosis to treat potentially serious health issues.

Hyperadrenocorticism in ferrets is linked to neutering and indoor housing, and is best treated with surgery and a deslorelin implant.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.

A Shi Tzu dog with high cortisol levels improved after increasing the dose of trilostane.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

Effective hirsutism management requires identifying the cause, combining new and traditional treatments, and setting realistic expectations for patients.

Women with PCOS have higher hair cortisol levels, which are linked to worse metabolic and inflammatory conditions.

A 70-year-old woman with a malignant adrenal tumor improved after surgery and radiotherapy.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.