Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that in male patients with androgenic alopecia, individuals with certain glutathione S-transferase gene polymorphisms exhibited higher oxidative stress and lower antioxidant capacity, although differences were not statistically significant, and oxidative stress appeared to increase with the progression of alopecia stages.

This study reported that in animal studies of androgenetic alopecia, a biodegradable microneedle patch releasing glutamic acid promoted hair regeneration more effectively than daily minoxidil, with higher hair follicle counts and less frequent dosing, showing the potential for clinical application.

This study observed an increased risk of alopecia areata among new users of GLP-1 agonists semaglutide and liraglutide compared to users of bupropion-naltrexone, highlighting potential hair loss concerns with these medications.

The study by Godfrey et al. highlights a potential link between GLP-1 receptor agonists, specifically semaglutide and tirzepatide, and the risk of alopecia, emphasizing the need for further investigation and patient awareness.

This report describes two cases of glucocorticoid resistance syndrome highlighting genetic diversity; one patient improved with low-dose dexamethasone despite negative genetic testing, while the other is monitored with a novel NR3C1 variant.

This study found that levels of gamma-glutamyl cysteine synthetase (ꝩ-GCS) were significantly higher in PCOS patients, suggesting a key role of glutathione metabolism in the disease's progression.

This study used a novel extraction method to detect and measure mineralocorticoids and glucocorticoids in hair follicles, concluding these steroids may serve as effective biomarkers for diagnosing conditions related to steroid excess or deficiency, such as Cushing’s syndrome and congenital adrenal hyperplasia.

This study found that GLP1-RAs, while not triggering significant safety signals, were reported more often for suicide, hair loss, and aspiration events compared to some other diabetes medications.

Glucocorticoid treatment in lupus can cause oral lesions, which need early diagnosis and comprehensive care.

In this study of mouse models, researchers found that glutaminolysis is crucial for macrophages to switch from a pro-inflammatory to a pro-resolving state, aiding tissue repair by preventing prolonged inflammation and influencing gene expression.

TAT-GILZ peptide promotes hair growth by boosting stem cell activity.

In this study, researchers identified a novel genetic variant in the NR3C1 gene in a mother and her son that predicts a truncated protein, leading to glucocorticoid resistance syndrome with mild hyperandrogenic features, although no clear genotype-phenotype correlation has been established.

This review provides an overview of various animal models used to study glucocorticoid-induced humanlike disorders, highlighting their utility in understanding side effects across multiple body systems, such as hypertension, osteoporosis, and depression-like behavior.

This research reports that transglucosylation significantly improved the water solubility of baicalin through the synthesis of baicalin glucosides, with BG1 and BG2 showing enhanced solubility and potential biological activity similar to baicalin in antioxidant and anti-glycation assays.

This case report suggests that genetic evaluation for glucocorticoid resistance, such as the NR3C1 gene variant, is crucial for proper diagnosis and management of patients showing atypical signs of hypercortisolism.

This study found that hair cortisol levels in black-tailed prairie dogs, influenced by factors like predation risk and lactation, were associated with reproductive success, supporting the Cort-Adaptation hypothesis.

This study found that women with hirsutism in the Amassoma metropolis had higher levels of testosterone, cholesterol, and glucose compared to non-bearded women.

This study suggests that stress-associated hair loss may occur due to increased androgen receptor expression and activity induced by dexamethasone in human and mouse dermal papilla cells.

This study found that exogenous glutamic acid promoted hair growth and keratinocyte proliferation, indicating a potential new signaling pathway in the skin.

This study surveyed patients with idiopathic inflammatory myopathy and found that glucocorticoid treatment commonly leads to adverse effects, particularly sleep disturbance, mood swings, and weight gain, with more severe effects reported by female patients.

This study found significant but small variations in glucocorticoid adherence among patients with giant cell arteritis, mainly due to medical advice rather than patient factors.

This study found that in women with PCOS in Port Harcourt, Nigeria, glucose homeostatic disorders were common, particularly among those with higher testosterone levels, suggesting the need for glucose disorder screening in this population.

In laboratory models of human skin, this study found that treating with resveratrol significantly increased glutathione levels, potentially enhancing the skin's antioxidant defenses.

This study explores the expression and function of 11β-HSD1 in human hair follicles and its potential regulation of glucocorticoid effects on dermal papilla cells, but reports no definitive findings on 11β-HSD1's role.

This study demonstrates that genome-edited epidermal stem cells can continuously monitor blood glucose levels in vivo and potentially aid in diabetes treatment through skin somatic gene therapy.

This study found that plasma protein binding significantly contributes to the shifts in glucocorticosteroid concentration ratios among blood, saliva, and hair, challenging prior assumptions about enzyme inactivation as the main factor.

This study found that manipulating 5αR2 activity in human hepatocytes in vitro can regulate lipogenesis, with potential clinical implications for patients taking 5αR inhibitors.

This study found that glucocorticoid use in rheumatoid arthritis patients is associated with dose-dependent risk of Cushingoid habitus, easy bruising, skin atrophy, and impaired wound healing, while other skin adverse effects are rare at lower doses.

This study found that Geranium Sibiricum L extract may promote hair growth by increasing cell proliferation and migration while modulating cytokine expression in human dermal papilla cells under stress conditions.

This study found that while most adolescents with PCOS do not show overt diabetes, over half have insulin resistance, and ethnicity is a significant predictor of type 2 diabetes.