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The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

Removing part of the vitamin D receptor stops vitamin D from working properly.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Hair growth and pigmentation in mice involve specific stages crucial for research.

The Rotterdam Study aims to understand various diseases in older adults.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

Oestrogens are key for bone growth during puberty in both boys and girls.

Pectin biosynthesis is essential for the growth of cotton fibers and Arabidopsis root hairs.

Blocking JAK-STAT signaling can lead to hair growth.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Androgens can cause hair growth in some areas and hair loss on the scalp.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Male pattern baldness involves genetics, hormones, and needs better treatments.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

Hair analysis can detect cocaine use but doesn't accurately show the amount or timing of use.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.